l-(4-Ethynylphenyl)-2,6,7-trioxabicyclo[2.2.2]octanes: A New Order of Potency for Insecticides Acting at the GABA-Gated Chloride Channel

Journal of Agricultural and Food Chemistry

Volumn 37, Issue 1, 1989, Pages 213-216

  Palmer, Christopher J ^a   Casida, John E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 2542429932     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf00085a049     Document Type: Article

References (8)

1. Casida, J. E.; Palmer, C. J. 2,6,7-Trioxabicyclo[2.2.2]octanes: Chemistry, Toxicology and Action at the GABA-Gated Chloride Channel. In Chloride Channels and Their Modulation by Neurotransmitters and Drugs; Biggio, G., Costa, E., Eds.; Advances in Biochemical Psychopharmacology; Raven: New York, 1988; Vol. 45, pp 109–123.
2. Casida J. E.; Palmer, C. J.; Cole, L. M. Bicycloorthocarboxylate Convulsants. Potent GabaaReceptor Antagonists. Mol. Pharmacol. 1985. 28. 246–253.
3. Nicholson, R. A.; Palmer, C. J.; Casida, J. E. 4-s-[3H]Butyl-l-(4-cyanophenyl)-2,6,7-trioxabicyclo[2.2.2]octane: Specific Binding in the American Cockroach Central Nervous System. In Neurotox '88; The Society of Chemical Industry: London, 1988; Abstracts pp 199–200.
4. Obata, T.; Yamamura, H. I.; Malatynska, E.; Ikeda, M.; Laird, H.; Palmer, C. J.; Casida, J. E. Modulation of γ-Aminobutyric Acid-Stimulated Chloride Influx by Bicycloorthocarboxylates, Bicyclophosphorus Esters, Polychlorocycloalkanes and Other Cage Convulsants. J. Pharmacol. Exp. Ther. 1988, 244, 802–806.
5. Palmer, C. J.; Casida, J. E. 1,4-Disubstituted 2,6,7-Trioxabicyclo[2.2.2]octanes: A New Class of Insecticides. J. Agric. Food Chem. 1985, 33, 976–980.
6. Palmer, C. J.; Casida, J. E. Bicycloorthocarboxylates: Potent Insecticides Acting at the GABA-Regulated Chloride Ionophore. In Sites of Action for Neurotoxic Pesticides; Hollingworth, R. M. Green, M. G., Eds.; ACS Symposium Series 356; American Chemical Society: Washington, DC, 1987; pp 71–82.
7. Stetter, H.; Uerdingen, W. Uber einen einfachen Weg zu α,β-ungesattigten Orthocarbonsaureestern. Synthesis 1973, 207–208.
8. Takahashi, S.; Kuroyama, Y.; Sonogashira, K.; Hagihara, N. A Convenient Synthesis of Ethynylarenes and Diethynylarenes. Synthesis 1980, 627–630.