-
4
-
-
1842431413
-
Tyrosine kinases as new molecular targets in treatment of inflammatory disorders and leukemia
-
F.M. Uckun, and C. Mao Tyrosine kinases as new molecular targets in treatment of inflammatory disorders and leukemia Curr. Pharm. Des. 10 2004 1083 1091
-
(2004)
Curr. Pharm. Des.
, vol.10
, pp. 1083-1091
-
-
Uckun, F.M.1
Mao, C.2
-
5
-
-
14444281534
-
Viracept (nelfinavir mesylate, AG1343): A potent, orally bioavailable inhibitor of HIV-1 protease
-
S.W. Kaldor, V.J. Kalish, J.F. Davies, B.V. Shetty, J.E. Fritz, K. Appelt, J.A. Burgess, K.M. Campanale, N.Y. Chirgadze, D.K. Clawson, B.A. Dressman, S.D. Hatch, D.A. Khalil, M.B. Kosa, P.P. Lubbehusen, M.A. Muesing, A.K. Patick, S.H. Reich, K.S. Su, and J.H. Tatlock Viracept (nelfinavir mesylate, AG1343): a potent, orally bioavailable inhibitor of HIV-1 protease J. Med. Chem. 40 1997 3979 3985
-
(1997)
J. Med. Chem.
, vol.40
, pp. 3979-3985
-
-
Kaldor, S.W.1
Kalish, V.J.2
Davies, J.F.3
Shetty, B.V.4
Fritz, J.E.5
Appelt, K.6
Burgess, J.A.7
Campanale, K.M.8
Chirgadze, N.Y.9
Clawson, D.K.10
Dressman, B.A.11
Hatch, S.D.12
Khalil, D.A.13
Kosa, M.B.14
Lubbehusen, P.P.15
Muesing, M.A.16
Patick, A.K.17
Reich, S.H.18
Su, K.S.19
Tatlock, J.H.20
more..
-
6
-
-
0035225042
-
Development of HIV protease inhibitors: A survey
-
S. Ren, and E.J. Lien Development of HIV protease inhibitors: a survey Prog. Drug Res. Spec. 2001 1 34
-
(2001)
Prog. Drug Res. Spec.
, pp. 1-34
-
-
Ren, S.1
Lien, E.J.2
-
7
-
-
0034805948
-
The first structure of a microsomal P450-Implications for drug discovery
-
M. Tennant, and D.E. McRee The first structure of a microsomal P450-Implications for drug discovery Curr. Opin. Drug Discov. Dev. 4 2001 671 677
-
(2001)
Curr. Opin. Drug Discov. Dev.
, vol.4
, pp. 671-677
-
-
Tennant, M.1
McRee, D.E.2
-
8
-
-
0028997717
-
2
-
2 Nat. Struct. Biol. 2 1995 458 465
-
(1995)
Nat. Struct. Biol.
, vol.2
, pp. 458-465
-
-
Schevitz, R.W.1
Bach, N.J.2
Carison, D.G.3
Chirgadze, N.Y.4
Clawson, D.K.5
Dillard, R.D.6
Draheim, S.E.7
Harley, L.W.8
Jones, N.D.9
Mihelich, E.D.10
Olkowski, J.L.11
Sayder, D.W.12
Sommers, C.13
Wery, J.P.14
-
13
-
-
0028039897
-
Bufo alvarius: A potent hallucinogen of animal origin
-
A.T. Weil, and W. Davia Bufo alvarius: a potent hallucinogen of animal origin J. Ethanopharmacol. 41 1994 1 8
-
(1994)
J. Ethanopharmacol.
, vol.41
, pp. 1-8
-
-
Weil, A.T.1
Davia, W.2
-
14
-
-
0018173123
-
Chemistry of Mediterranean Gorgonians. Simple indole derivatives from Paramuricea chamaeleon
-
G. Cimino, and S. De Stefano Chemistry of Mediterranean Gorgonians. Simple indole derivatives from Paramuricea chamaeleon C. R. Biochem. Physiol., Ser. C 61 1978 361 362
-
(1978)
C. R. Biochem. Physiol., Ser. C
, vol.61
, pp. 361-362
-
-
Cimino, G.1
De Stefano, S.2
-
15
-
-
0017811021
-
Hallucinogenic N-methylated indole alkylamines in the cerebrospinal fluid of psychiatric and control populations
-
L. Corbett Hallucinogenic N-methylated indole alkylamines in the cerebrospinal fluid of psychiatric and control populations Br. J. Psychiatry 132 1978 139 144
-
(1978)
Br. J. Psychiatry
, vol.132
, pp. 139-144
-
-
Corbett, L.1
-
16
-
-
0004151381
-
-
MSc thesis, University Hamburg, Hamburg, Germany
-
T. Schulze, Ein Echtheitsystem zur Messung der dynamishen Lichtstreuung in flussigkeiten, MSc thesis, University Hamburg, Hamburg, Germany, 1996.
-
(1996)
Ein Echtheitsystem Zur Messung der Dynamishen Lichtstreuung in Flussigkeiten
-
-
Schulze, T.1
-
17
-
-
0031059866
-
Processing of X-ray diffraction data collected in oscillation mode
-
Z. Otwinowski, and W. Minor Processing of X-ray diffraction data collected in oscillation mode Methods Enzymol. 176 1997 307 326
-
(1997)
Methods Enzymol.
, vol.176
, pp. 307-326
-
-
Otwinowski, Z.1
Minor, W.2
-
18
-
-
0035788101
-
AMoRe: An automated package for molecular replacement
-
J. Navaza AMoRe: an automated package for molecular replacement Acta Crystallogr. D57 2001 1367 1372
-
(2001)
Acta Crystallogr.
, vol.57
, pp. 1367-1372
-
-
Navaza, J.1
-
20
-
-
0014432781
-
Solvent content of protein crystals
-
B.W. Matthews Solvent content of protein crystals J. Mol. Biol. 33 1968 491 497
-
(1968)
J. Mol. Biol.
, vol.33
, pp. 491-497
-
-
Matthews, B.W.1
-
21
-
-
0030924992
-
Refinement of macromolecular structures by the maximum-likelihood method
-
G.N. Murshudov, A.A. Vagin, and E.J. Dodson Refinement of macromolecular structures by the maximum-likelihood method Acta Crystallogr. D53 1997 240 255
-
(1997)
Acta Crystallogr.
, vol.53
, pp. 240-255
-
-
Murshudov, G.N.1
Vagin, A.A.2
Dodson, E.J.3
-
22
-
-
84889120137
-
Improved methods for building models in electron density maps and the location of errors in these models
-
T.A. Jones, J. Zou, S.W. Cowan, and M. Kjeldgaard Improved methods for building models in electron density maps and the location of errors in these models Acta Crystallogr. A47 1991 110 119
-
(1991)
Acta Crystallogr.
, vol.47
, pp. 110-119
-
-
Jones, T.A.1
Zou, J.2
Cowan, S.W.3
Kjeldgaard, M.4
-
23
-
-
79952608525
-
Accurate bond and angle parameters for X-ray protein structure refinement
-
R.A. Engh, and R. Huber Accurate bond and angle parameters for X-ray protein structure refinement Acta Crystallogr. A47 1991 392 400
-
(1991)
Acta Crystallogr.
, vol.47
, pp. 392-400
-
-
Engh, R.A.1
Huber, R.2
-
26
-
-
0015705448
-
Indole compounds of the venom of the South Indian scorpion, H. scaber
-
R.B. Nair, R.K. Jaj, and P.A. Kurup Indole compounds of the venom of the South Indian scorpion, H. scaber Indian J. Biochem. Biophys. 10 1973 231 232
-
(1973)
Indian J. Biochem. Biophys.
, vol.10
, pp. 231-232
-
-
Nair, R.B.1
Jaj, R.K.2
Kurup, P.A.3
-
27
-
-
0016413774
-
Investigations on the venom of the South Indian scorpion Heterometrus scaber
-
R.B. Nair, and P.A. Kurup Investigations on the venom of the South Indian scorpion Heterometrus scaber Biochim. Biophys. Acta 381 1975 165 174
-
(1975)
Biochim. Biophys. Acta
, vol.381
, pp. 165-174
-
-
Nair, R.B.1
Kurup, P.A.2
-
28
-
-
0034790792
-
The acylpolyamines from the venom of the spider, Agelenopsis apert
-
S. Chesnov, L. Bigler, and M. Hesse The acylpolyamines from the venom of the spider, Agelenopsis apert Helv. Chim. Acta 84 2001 2178 2197
-
(2001)
Helv. Chim. Acta
, vol.84
, pp. 2178-2197
-
-
Chesnov, S.1
Bigler, L.2
Hesse, M.3
-
29
-
-
0032559937
-
Structural characterization of a new acylpolyaminetoxin from the venom of Brazilian garden spider Nephilengys cruentata
-
M.S. Palma, Y. Itagaki, T. Fujita, H. Naoki, and T. Nakajima Structural characterization of a new acylpolyaminetoxin from the venom of Brazilian garden spider Nephilengys cruentata Toxicon 36 1998 485 493
-
(1998)
Toxicon
, vol.36
, pp. 485-493
-
-
Palma, M.S.1
Itagaki, Y.2
Fujita, T.3
Naoki, H.4
Nakajima, T.5
-
30
-
-
0024563048
-
Isolation and structure analysis of components from venom of the spider Argiope lobata
-
E.V. Grishin, T.M. Volkova, and A.S. Arseniev Isolation and structure analysis of components from venom of the spider Argiope lobata Toxicon 27 1989 541 549
-
(1989)
Toxicon
, vol.27
, pp. 541-549
-
-
Grishin, E.V.1
Volkova, T.M.2
Arseniev, A.S.3
-
42
-
-
0028860035
-
Binding mode of phospholipase A2 with a new type of phospholipid analog having an oxazolidinone ring
-
T. Tani, S. Fujii, S. Inoue, K. Ikeda, S. Iwama, T. Matsuda, S. Katsumura, Y. Samejima, and K. Hayashi Binding mode of phospholipase A2 with a new type of phospholipid analog having an oxazolidinone ring J. Biochem. (Tokyo) 117 1995 176 182
-
(1995)
J. Biochem. (Tokyo)
, vol.117
, pp. 176-182
-
-
Tani, T.1
Fujii, S.2
Inoue, S.3
Ikeda, K.4
Iwama, S.5
Matsuda, T.6
Katsumura, S.7
Samejima, Y.8
Hayashi, K.9
-
43
-
-
0023186213
-
Characterization of three edema-inducing phospholipase A2 enzymes from habu (Trimeresurus flavoviridis) venom and their interaction with the alkaloid aristolochic acid
-
B.S. Vishwanath, R.M. Kini, and T.V. Gowda Characterization of three edema-inducing phospholipase A2 enzymes from habu (Trimeresurus flavoviridis) venom and their interaction with the alkaloid aristolochic acid Toxicon 25 1987 501 515
-
(1987)
Toxicon
, vol.25
, pp. 501-515
-
-
Vishwanath, B.S.1
Kini, R.M.2
Gowda, T.V.3
-
46
-
-
3042599028
-
2 by novel 2-oxoamides in vitro, in cells, and in vivo
-
2 by novel 2-oxoamides in vitro, in cells, and in vivo J. Med. Chem. 47 2004 3615 3628
-
(2004)
J. Med. Chem.
, vol.47
, pp. 3615-3628
-
-
Kokotos, G.1
Six, D.A.2
Loukas, V.3
Smith, T.4
Constantinou-Kokotou, V.5
Hadjipavlou-Litina, D.6
Kotsovolou, S.7
Chiou, A.8
Beltzner, C.C.9
Dennis, E.A.10
-
48
-
-
14844300808
-
A molecular mechanism for Lys49-phospholipase A2 activity based on ligand-induced conformational change
-
A.L.B. Ambrosio, M.C. Nonato, H.S. Selistre De Araujo, R. Arni, R.J. Ward, C.L. Ownby, D.H.F. De Souza, and R.C. Garratt A molecular mechanism for Lys49-phospholipase A2 activity based on ligand-induced conformational change J. Biol. Chem. 280 2005 7326
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 7326
-
-
Ambrosio, A.L.B.1
Nonato, M.C.2
Selistre De Araujo, H.S.3
Arni, R.4
Ward, R.J.5
Ownby, C.L.6
De Souza, D.H.F.7
Garratt, R.C.8
-
50
-
-
0344177560
-
Structure of a Lys49-phospholipase A2 homologue isolated from the venom of Bothrops nummifer (jumping viper)
-
W.F. de Azevedo Jr., R.J. Ward, J.M. Gutierrez, and R.K. Arni Structure of a Lys49-phospholipase A2 homologue isolated from the venom of Bothrops nummifer (jumping viper) Toxicon 37 1999 371 384
-
(1999)
Toxicon
, vol.37
, pp. 371-384
-
-
De Azevedo Jr., W.F.1
Ward, R.J.2
Gutierrez, J.M.3
Arni, R.K.4
-
51
-
-
0029075934
-
SB 203347, an inhibitor of 14 kDa phospholipase A2, alters human neutrophil arachidonic acid release and metabolism and prolongs survival in murine endotoxin shock
-
L.A. Marshall, R.H. Hall, J.D. Winkler, A. Badger, B. Bolognese, A. Roshak, P.L. Flamberg, C.M. Sung, M. Chabot-Fletcher, and J.L. Adams SB 203347, an inhibitor of 14 kDa phospholipase A2, alters human neutrophil arachidonic acid release and metabolism and prolongs survival in murine endotoxin shock J. Pharmacol. Exp. Ther. 274 1995 1254 1262
-
(1995)
J. Pharmacol. Exp. Ther.
, vol.274
, pp. 1254-1262
-
-
Marshall, L.A.1
Hall, R.H.2
Winkler, J.D.3
Badger, A.4
Bolognese, B.5
Roshak, A.6
Flamberg, P.L.7
Sung, C.M.8
Chabot-Fletcher, M.9
Adams, J.L.10
-
52
-
-
0028241586
-
Inhibition of the myotoxic and hemorrhagic activities of crotalid venoms by Eclipta prostrata (Asteraceae) extracts and constituents
-
P.A. Melo, M.C. do Nascimento, W.B. Mors, and G. Suarez-Kurtz Inhibition of the myotoxic and hemorrhagic activities of crotalid venoms by Eclipta prostrata (Asteraceae) extracts and constituents Toxicon 32 1994 595 603
-
(1994)
Toxicon
, vol.32
, pp. 595-603
-
-
Melo, P.A.1
Do Nascimento, M.C.2
Mors, W.B.3
Suarez-Kurtz, G.4
-
53
-
-
0024415801
-
Neutralization of lethal and myotoxic activities of South American rattlesnake venom by extracts and constituents of the plant Eclipta prostrata (Asteraceae)
-
W.B. Mors, M.C. do Nascimento, J.P. Parente, M.H. da Silva, P.A. Melo, and G. Suarez-Kurtz Neutralization of lethal and myotoxic activities of South American rattlesnake venom by extracts and constituents of the plant Eclipta prostrata (Asteraceae) Toxicon 27 1989 1003 1009
-
(1989)
Toxicon
, vol.27
, pp. 1003-1009
-
-
Mors, W.B.1
Do Nascimento, M.C.2
Parente, J.P.3
Da Silva, M.H.4
Melo, P.A.5
Suarez-Kurtz, G.6
-
54
-
-
0141706625
-
2
-
2 J. Mol. Biol. 333 2003 367 376
-
(2003)
J. Mol. Biol.
, vol.333
, pp. 367-376
-
-
Sekar, K.1
Vaijayanthi, M.S.2
Yogavel, M.3
Velmurugan, D.4
Poi, M.J.5
Vishwanath, B.S.6
Gowda, T.V.7
Jeyaprakash, A.A.8
Tsai, M.D.9
-
55
-
-
0029796132
-
2 by synthetic peptides derived from the primary sequence
-
2 by synthetic peptides derived from the primary sequence J. Biol. Chem. 271 1996 23992 23998
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 23992-23998
-
-
Tseng, A.1
Inglis, A.S.2
Scott, K.F.3
-
56
-
-
0035980093
-
A novel approach to the design of inhibitors of human secreted phospholipase A2 based on native peptide inhibition
-
W.B. Church, A.S. Inglis, A. Tseng, R. Duell, P.W. Lei, K.J. Bryant, and K.F. Scott A novel approach to the design of inhibitors of human secreted phospholipase A2 based on native peptide inhibition J. Biol. Chem. 276 2001 33156 33164
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 33156-33164
-
-
Church, W.B.1
Inglis, A.S.2
Tseng, A.3
Duell, R.4
Lei, P.W.5
Bryant, K.J.6
Scott, K.F.7
-
57
-
-
2542458406
-
Crystallization and preliminary X-ray diffraction analysis of an acidic phospholipase A(2) complexed with p-bromophenacyl bromide and alpha-tocopherol inhibitors at 1.9- and 1.45-A resolution
-
A.A. Takeda, J.I. dos Santos, S. Marcussi, L.B. Silveira, A.M. Soares, and M.R. Fontes Crystallization and preliminary X-ray diffraction analysis of an acidic phospholipase A(2) complexed with p-bromophenacyl bromide and alpha-tocopherol inhibitors at 1.9- and 1.45-A resolution Biochim. Biophys. Acta 1699 2004 281 284
-
(2004)
Biochim. Biophys. Acta
, vol.1699
, pp. 281-284
-
-
Takeda, A.A.1
Dos Santos, J.I.2
Marcussi, S.3
Silveira, L.B.4
Soares, A.M.5
Fontes, M.R.6
-
58
-
-
13444287715
-
2
-
2 J. Med. Chem. 48 2005 893 896
-
(2005)
J. Med. Chem.
, vol.48
, pp. 893-896
-
-
Sawyer, J.S.1
Beight, D.W.2
Smith, E.C.3
Snyder, D.W.4
Chastain, M.K.5
Tielking, R.L.6
Hartley, L.W.7
Carlson, D.G.8
-
60
-
-
0344064798
-
Structure-activity relationships of indole cytosolic phospholipase A(2)alpha inhibitors: Substrate mimetics
-
J.C. McKew, F. Lovering, J.D. Clark, J. Bemis, Y. Xiang, M. Shen, W. Zhang, J.C. Alvarez, and D. Joseph-McCarthy Structure-activity relationships of indole cytosolic phospholipase A(2)alpha inhibitors: substrate mimetics Bioorg. Med. Chem. Lett. 13 2003 4501 4504
-
(2003)
Bioorg. Med. Chem. Lett.
, vol.13
, pp. 4501-4504
-
-
McKew, J.C.1
Lovering, F.2
Clark, J.D.3
Bemis, J.4
Xiang, Y.5
Shen, M.6
Zhang, W.7
Alvarez, J.C.8
Joseph-Mccarthy, D.9
-
61
-
-
12644258541
-
2. 1. Indole-3-acetamides
-
2. 1. Indole-3-acetamides J. Med. Chem. 39 1996 5119 5136
-
(1996)
J. Med. Chem.
, vol.39
, pp. 5119-5136
-
-
Draheim, S.E.1
Bach, N.J.2
Dillard, R.D.3
Berry, D.R.4
Carlson, D.G.5
Chirgadze, N.Y.6
Clawson, D.K.7
Hartley, L.W.8
Johnson, L.M.9
Jones, N.D.10
McKinney, E.R.11
Mihelich, E.D.12
Olkowski, J.L.13
Schevitz, R.W.14
Smith, A.C.15
Snyder, D.W.16
Sommers, C.D.17
Wery, J.P.18
-
62
-
-
12644249111
-
2. 2. Indole-3-acetamides with additional functionality
-
2. 2. Indole-3-acetamides with additional functionality J. Med. Chem. 39 1996 5137 5158
-
(1996)
J. Med. Chem.
, vol.39
, pp. 5137-5158
-
-
Draheim, S.E.1
Bach, N.J.2
Dillard, R.D.3
Berry, D.R.4
Carlson, D.G.5
Chirgadze, N.Y.6
Clawson, D.K.7
Hartley, L.W.8
Johnson, L.M.9
Jones, N.D.10
McKinney, E.R.11
Mihelich, E.D.12
Olkowski, J.L.13
Schevitz, R.W.14
Smith, A.C.15
Snyder, D.W.16
Sommers, C.D.17
Wery, J.P.18
-
63
-
-
12644262408
-
2. 3. Indole-3-glyoxamides
-
2. 3. Indole-3-glyoxamides J. Med. Chem. 39 1996 5159 5175
-
(1996)
J. Med. Chem.
, vol.39
, pp. 5159-5175
-
-
Draheim, S.E.1
Bach, N.J.2
Dillard, R.D.3
Berry, D.R.4
Carlson, D.G.5
Chirgadze, N.Y.6
Clawson, D.K.7
Hartley, L.W.8
Johnson, L.M.9
Jones, N.D.10
McKinney, E.R.11
Mihelich, E.D.12
Olkowski, J.L.13
Schevitz, R.W.14
Smith, A.C.15
Snyder, D.W.16
Sommers, C.D.17
Wery, J.P.18
-
64
-
-
0001099937
-
Traitement statistique des erreurs dans la determination des structures cristallines
-
V. Luzzati Traitement statistique des erreurs dans la determination des structures cristallines Acta Crystallogr. 5 1952 802 810
-
(1952)
Acta Crystallogr.
, vol.5
, pp. 802-810
-
-
Luzzati, V.1
-
65
-
-
84944812409
-
Improved Fourier coefficients for maps using phases from partial structures with errors
-
R.J. Read Improved Fourier coefficients for maps using phases from partial structures with errors Acta Crystallogr., A 42 1986 140 149
-
(1986)
Acta Crystallogr., a
, vol.42
, pp. 140-149
-
-
Read, R.J.1
-
66
-
-
0030729838
-
An extensively modified version of Molscript that includes greatly enhanced coloring capabilities
-
R.M. Esnouf An extensively modified version of Molscript that includes greatly enhanced coloring capabilities J. Mol. Graph. 15 1997 132 134
-
(1997)
J. Mol. Graph.
, vol.15
, pp. 132-134
-
-
Esnouf, R.M.1
-
67
-
-
0028057108
-
Raster 3D Version 2.0: A program for photorealistic molecular graphics
-
E.A. Merritt, and M.E.P. Murphy Raster 3D Version 2.0: a program for photorealistic molecular graphics Acta Crystallogr. D50 1994 869 873
-
(1994)
Acta Crystallogr.
, vol.50
, pp. 869-873
-
-
Merritt, E.A.1
Murphy, M.E.P.2
-
68
-
-
0028922586
-
LIGPLOT: A program to generate schematic diagrams of protein-ligand interactions
-
A.C. Wallace, R.A. Laskowski, and J.M. Thornton LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions Protein Eng. 8 1995 127 134
-
(1995)
Protein Eng.
, vol.8
, pp. 127-134
-
-
Wallace, A.C.1
Laskowski, R.A.2
Thornton, J.M.3
|