메뉴 건너뛰기




Volumn 26, Issue 6, 2005, Pages 225-232

Chiral aspects of the human metabolism of ethosuximide

Author keywords

Ethosuximide; GC MS; Human metabolism

Indexed keywords

2 (1 HYDROXYETHYL) 2 METHYLSUCCINIMIDE; 2 ETHYL 2 HYDROXYMETHYLSUCCINIMIDE; 2 ETHYL 3 HYDROXY 2 METHYLSUCCINIMIDE; BETA GLUCURONIDASE; CYTOCHROME P450 3A; DRUG METABOLITE; ETHOSUXIMIDE; UNCLASSIFIED DRUG;

EID: 25144519354     PISSN: 01422782     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdd.454     Document Type: Article
Times cited : (8)

References (13)
  • 1
    • 84948013696 scopus 로고
    • Physiological disposition of α-methyl-α-ethylsuccinimide (ethosuximide, Zarontin®) in animals and in man
    • Proceedings of 149th National Meeting, American Chemical Society: Detroit, Michigan, Washington, 30N
    • Dill WA, Peterson L, Chang T, Glazko AJ. Physiological disposition of α-methyl-α-ethylsuccinimide (ethosuximide, Zarontin®) in animals and in man. In Proceedings of 149th National Meeting, American Chemical Society: Detroit, Michigan, Washington, 1965; 30N.
    • (1965)
    • Dill, W.A.1    Peterson, L.2    Chang, T.3    Glazko, A.J.4
  • 2
    • 25144462085 scopus 로고
    • A hydroxylated metabolite of ethosuximide (Zarontin®) in rat urine
    • Burkett AR, Chang T, Glazko AJ. A hydroxylated metabolite of ethosuximide (Zarontin®) in rat urine. Fed Proc 1971; 30: 91.
    • (1971) Fed. Proc. , vol.30 , pp. 91
    • Burkett, A.R.1    Chang, T.2    Glazko, A.J.3
  • 3
    • 0007490610 scopus 로고
    • Ethosuximide - Biotransformation
    • Woodbury DM, Penry JK, Schmidt RP (eds), 1st edn. Raven Press: New York
    • Chang T, Burkett AR, Glazko AJ. Ethosuximide - biotransformation. In Antiepileptic Drugs, Woodbury DM, Penry JK, Schmidt RP (eds), 1st edn. Raven Press: New York, 1972, 425-429.
    • (1972) Antiepileptic Drugs , pp. 425-429
    • Chang, T.1    Burkett, A.R.2    Glazko, A.J.3
  • 5
    • 25144503397 scopus 로고
    • Ethosuximide - Biotransformation
    • Woodbury DM, Penry JK, Schmidt RP (eds), 2nd edn. Raven Press: New York
    • Chang T, Burkett AR. Ethosuximide - biotransformation. In Antiepileptic Drugs, Woodbury DM, Penry JK, Schmidt RP (eds), 2nd edn. Raven Press: New York, 1982; 631-635.
    • (1982) Antiepileptic Drugs , pp. 631-635
    • Chang, T.1    Burkett, A.R.2
  • 6
    • 0015969519 scopus 로고
    • Identification of 2-ethyl-2-methyl-3-hydroxy succinimide as a major metabolite of ethosuximide in humans
    • Preste PG, Westerman CE, Das NP, Wilder BJ, Duncan JH. Identification of 2-ethyl-2-methyl-3-hydroxy succinimide as a major metabolite of ethosuximide in humans. J Pharm Sci 1974; 63: 467-469.
    • (1974) J. Pharm. Sci. , vol.63 , pp. 467-469
    • Preste, P.G.1    Westerman, C.E.2    Das, N.P.3    Wilder, B.J.4    Duncan, J.H.5
  • 8
    • 0018232742 scopus 로고
    • Urinary metabolites of 2-ethyl-2-methylsuccinimide (ethosuximide) studied by combined gas chromatography mass spectrometry
    • Petterson JE. Urinary metabolites of 2-ethyl-2-methylsuccinimide (ethosuximide) studied by combined gas chromatography mass spectrometry. Biomed Mass Spectrom 1978; 5: 601-603.
    • (1978) Biomed. Mass Spectrom. , vol.5 , pp. 601-603
    • Petterson, J.E.1
  • 9
    • 0025034404 scopus 로고
    • Nonstereoselective disposition of ethosuximide in humans
    • Villen T, Bertilsson L, Sjoqvist F. Nonstereoselective disposition of ethosuximide in humans. Ther Drug Monit 1990; 12: 514-516.
    • (1990) Ther. Drug Monit. , vol.12 , pp. 514-516
    • Villen, T.1    Bertilsson, L.2    Sjoqvist, F.3
  • 13
    • 0037357282 scopus 로고    scopus 로고
    • Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of ethosuximide by human hepatic microsomal enzymes
    • Bachmann Kin, He Y, Sarver JG, Ping N. Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of ethosuximide by human hepatic microsomal enzymes. Xenobiotica 2003; 33: 265-276.
    • (2003) Xenobiotica , vol.33 , pp. 265-276
    • Bachmann, K.1    He, Y.2    Sarver, J.G.3    Ping, N.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.