Inhibition of serotonin transporters by cocaine and meprylcaine through 5-TH2C receptor stimulation facilitates their seizure activities

Brain Research

Volumn 1057, Issue 1-2, 2005, Pages 153-160

  Morita, Katsuya ^a   Hamamoto, Masahiro ^a   Arai, Shigeaki ^a   Kitayama, Shigeo ^b   Irifune, Masahiro ^a   Kawahara, Michio ^a   Kihira, Kenji ^c   Dohi, Toshihiro ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

^c HIROSHIMA UNIVERSITY HOSPITAL   (Japan)

Author keywords

Cocaine; Convulsion; Local anesthetics; Serotonin transporter; SSRI

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; 1 (1 METHYL 5 INDOLYL) 3 (3 METHYL 5 ISOTHIAZOLYL)UREA; 1 [5 (2 THIENYLMETHOXY) 3 INDOLYL] 2 PROPANAMINE; 1 ISOPROPYL 6 METHYLERGOLINE 8 CARBOXYLIC ACID 2 HYDROXY 1 METHYLPROPYL ESTER; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; 6 CHLORO 2 (1 PIPERAZINYL)PYRAZINE; 8 [4 (5 AMINO 2,4 DIMETHOXYBENZOYL)BUTYL] 1,3,8 TRIAZASPIRO[4.5]DECANE 2,4 DIONE; 8 [5 (2,4 DIMETHOXY 5 (4 TRIFLUOROMETHYLPHENYLSULFONAMIDO)PHENYL 5 OXOPENTYL) 1,3,8 TRIAZASPIRO[4,5]DECANE 2,4 DIONE]; CITALOPRAM; COCAINE; CONVULSANT AGENT; FLUOXETINE; GLEMANSERIN; ISOPROTEIN; KETANSERIN; LIDOCAINE; LOCAL ANESTHETIC AGENT; MEPRYLCAINE; SB 204714; SEROTONIN 2A AGONIST; SEROTONIN 2A ANTAGONIST; SEROTONIN 2B RECEPTOR; SEROTONIN 2C AGONIST; SEROTONIN 2C ANTAGONIST; SEROTONIN 2C RECEPTOR; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR; UNCLASSIFIED DRUG; ZIMELDINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CONVULSION; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; INCIDENCE; MALE; MOUSE; NONHUMAN; PLASMA; PRIORITY JOURNAL; PROTEIN FUNCTION; SEIZURE;

ANESTHETICS, LOCAL; ANIMALS; ANTICONVULSANTS; BEHAVIOR, ANIMAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COCAINE; DOPAMINE UPTAKE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ELECTROCHEMISTRY; LIDOCAINE; MALE; MICE; MICE, INBRED ICR; RECEPTOR, SEROTONIN, 5-HT2C; SEIZURES; SEROTONIN AGONISTS; SEROTONIN UPTAKE INHIBITORS;

EID: 25144518097     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2005.07.049     Document Type: Article

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