Safety and efficacy of a bilayered skin construct in full-thickness surgical wounds

Journal of Dermatology

Volumn 32, Issue 8, 2005, Pages 626-631

  Donohue, Kevin G ^a   Carson, Polly ^a   Iriondo, Manuel ^a   Zhou, Linda ^a   Saap, Liliana ^a   Gibson, Kathleen ^a   Falanga, Vincent ^a,b  

^a ROGER WILLIAMS MEDICAL CENTER   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apligraf; Bioengineered skin; Non melanoma skin cancer; Skin surgery; Wounds

Indexed keywords

AGED; ARTICLE; BIOENGINEERING; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; MALE; PATIENT SATISFACTION; POSTOPERATIVE PAIN; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SKIN CANCER; SKIN CONSTRUCT; SKIN GRAFT; SURGICAL WOUND; TISSUE ENGINEERING; TREATMENT OUTCOME; WOUND CLOSURE; WOUND HEALING;

EID: 25144508179     PISSN: 03852407     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1346-8138.2005.tb00811.x     Document Type: Article

References (17)

1. Diepgen TL, Mahler V: The epidemiology of skin cancer, Br J Dermatol, 146 (Suppl 61): 1-6, 2002.
2. Gloster HM Jr, Brodland DG: The epidemiology of skin cancer, Dermatol Surg, 22: 217-226, 1996.
3. Martinez JC, Otley CC: The management of melanoma and non-melanoma skin cancers. A review for the primary care physician, Mayo Clinic Proceedings, 76: 1253-1265, 2001.
4. Falanga V, Margolis D, Alvarez O, et al: Rapid healing of venous ulcers and lack of clinical rejection with an allogeneic cultured human skin equivalent, Arch Dermatol, 134: 293-300, 1998.
5. Veves A, Falanga V, Armstrong DG, Sabolinski ML, for the Apligraf Diabetic Foot Ulcer Study: Graftskin, a human skin equivalent, is effective in the management of noninfected neuropathic foot ulcers, Diabetes Care, 24: 290-295, 2001.
6. de Imus G, Golumb C, Wilkel C, Tsoukas, M, Nowak M, Falanga V: Accelerated healing of pyoderma gangrenosum treated with bioengineered skin and concomitant immunosuppression, J Am Acad Dermatol, 44: 61-66, 2001.
7. Long RE, Falabella AF, Valencia I, Eaglstein AVH, Kirsner RS: Treatment of refractory, atypical lower extremity ulcers with tissue engineered skin (Apligraf), Arch Dermatol, 137: 1660-1661, 2001.
8. Gohari S, Gambla C, Healey M, et al: Evaluation of tissue-engineered skin (human skin substitute) and secondary intention healing in the treatment of full thickness wounds after Mohs micrographic or excisional surgery, Dermatol Surg, 28: 1107-1114, 2002.
9. Mathias SD, Prebil, LA, Boyko WL, Fastenau J: Health-related quality of life in venous leg ulcer patients successfully treated with Apligraf: a pilot study, Advances in Skin and Wound Care, 13: 76-78, 2000.
10. Eaglstein WH, Iriondo M, Laszlo K: A composite skin substitute (Graftskin) for surgical wounds, Dermatol Surg, 21: 839-843, 1995.
11. Waymack P, Duff RG, Sabolinski M, for the Apligraf Burn Study Group: The effect of a tissue engineered bilayered living skin analog, over meshed split-thickness autografts on the healing of excised wounds, Burns, 26: 609-619, 2000.
12. Tarlow MM, Nossa R, Spencer JM: Effective management of difficult surgical defects using tissue-engineered skin, Dermatol Surg, 27: 71-74, 2001.
13. Eaglstein WH, Alvarez OM, Auletta A, et al: Acute excisional wounds treated with a tissue-engineered skin (Apligraf), Dermatol Surg, 25: 195-201, 1999.
14. Muhart M, McFalls S, Kirsner RS, et al: Behavior of Tissue-Engineered Skin: A Comparison of a Living Skin Equivalent, Autograft, and Occlusive Dressing in Human Donor Sites, Arch Dermatol, 135: 913-918, 1999.
15. Cook JL, Perone JB: A prospective evaluation of the incidence of complications associated with Mohs micrographic surgery, Arch Dermatol, 139: 143-152, 2003.
16. Futoryan T, Grande D: Postoperative wound infection rates in dermatologic surgery, Dermatol Surg, 21: 509-514, 1995.
17. Badiavas EV, Paquette D, Carson P, Falanga V: Human chronic wounds treated with bioengineered skin: histologic evidence of host-graft interactions, J Am Acad Dermatol, 46: 524-530, 2002.