Association of polymorphisms of platelet membrane integrins αIIbβ3 (HPA-1b/PlA2) and α2β1 (α2807TT) with premature myocardial infarction

Journal of Thrombosis and Haemostasis

Volumn 3, Issue 7, 2005, Pages 1522-1529

  Zotz, R B ^a,e   Winkelmann, B R ^b   Muller C ^a   Boehm, B O ^c   Marz W ^d   Scharf, R E ^a  

^a UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY HOSPITAL ULM   (Germany)

^d MEDICAL UNIVERSITY OF GRAZ   (Austria)

^e HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

GPIa IIa; GPIIb IIIa; Myocardial infarction; Platelet membrane glycoproteins; Platelet receptor polymorphisms

Indexed keywords

INTEGRIN; THROMBOCYTE ANTIGEN; THROMBOCYTE RECEPTOR; VERY LATE ACTIVATION ANTIGEN 2; FIBRINOGEN RECEPTOR;

ADULT; AGED; ANAMNESIS; ANGIOCARDIOGRAPHY; ARTICLE; BETA CHAIN; BLOOD DONOR; CARDIOVASCULAR RISK; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY DISEASE; DIABETES MELLITUS; GENETIC POLYMORPHISM; GENOTYPE; HEART INFARCTION; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PREVALENCE; PRIORITY JOURNAL; SMOKING; THROMBOCYTE MEMBRANE; THROMBOGENICITY; ALLELE; ANGIOGRAPHY; CASE CONTROL STUDY; FEMALE; FOLLOW UP; GENETICS; HETEROZYGOTE; MIDDLE AGED; ONSET AGE; RISK; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; TIME; TREATMENT OUTCOME;

AGE OF ONSET; AGED; ALLELES; ANGIOGRAPHY; BLOOD DONORS; CASE-CONTROL STUDIES; CORONARY ARTERIOSCLEROSIS; FEMALE; FOLLOW-UP STUDIES; GENOTYPE; HETEROZYGOTE; HUMANS; INTEGRIN ALPHA2BETA1; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; MYOCARDIAL INFARCTION; ODDS RATIO; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK; RISK FACTORS; TIME FACTORS; TREATMENT OUTCOME;

EID: 25144491186     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2005.01432.x     Document Type: Article

References (35)

1. Fitzgerald DJ, Roy L, Catella F, FitzGerald GA. Platelet activation in unstable coronary disease. N Engl J Med 1986; 315: 983-9.
2. Fuster V, Badimon L, Badimon JJ, Chesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndromes (1). N Engl J Med 1992; 326: 242-50.
3. Lam JY, Chesebro JH, Steele PM, Dewanjee MK, Badimon L, Fuster V. Deep arterial injury during experimental angioplasty: relation to a positive indium-111-labeled platelet scintigram, quantitative platelet deposition and mural thrombosis. J Am Coll Cardiol 1986; 8: 1380-6.
4. Yeghiazarians Y, Braunstein JB, Askari A, Stone PH. Unstable angina pectoris. N Engl J Med 2000; 342: 101-14.
5. Perutelli P, Mori PG. The human platelet membrane glycoprotein IIb/ IIIa complex: a multi functional adhesion receptor. Haematologica 1992; 77: 162-8.
6. Nurden AT. Polymorphisms of human platelet membrane glycoproteins: structure and clinical significance. Thromb Haemost 1995; 74: 345-51.
7. Scharf RE. Molecular basis and clinical aspects of hereditary megakaryocyte and platelet membrane glycoprotein disorders. Hämostaseologie 1996; 16: 114-38.
8. Kunicki TJ, Newman PJ. The molecular immunology of human platelet proteins. Blood 1992; 80: 1386-404.
9. Weiss EJ, Bray PF, Tayback M, Schulman SP, Kickler TS, Becker LC, Weiss JL, Gerstenblith G, Goldschmidt-Clermont PJ. A polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis. N Engl J Med 1996; 334: 1090-4.
10. Bray PF. Integrin polymorphisms as risk factors for thrombosis. Thromb Haemost 1999; 82: 337-44.
11. Di Castelnuovo A, de Gaetano G, Donati MB, lacoviello L. Platelet glycoprotein receptor IIIa polymorphism PIA1/PIA2 and coronary risk: a meta-analysis. Thromb Haemost 2001; 85: 626-33.
12. Zhu MM, Weedon J, Clark LT. Meta-analysis of the association of platelet glycoprotein IIIa PIA1/A2 polymorphism with myocardial infarction. Am J Cardiol 2000; 86: 1000-5.
13. Zotz RB, Scharf RE. Platelet receptor polymorphism and their role in cardiovascular disease. J Lab Med 2002; 26: 584-93.
14. Elices MJ, Hemler ME. The human integrin VLA-2 is a collagen receptor on some cells and a collagen/laminin receptor on others. Proc Natl Acad Sci USA 1989; 86: 9906-10.
15. Kirchhofer D, Languino LR, Ruoslahti E, Pierschbacher MD. Alpha 2 beta 1 integrins from different cell types show different binding specificities. J Biol Chem 1990; 265: 615-8.
16. Kritzik M, Savage B, Nugent DJ, Santoso S, Ruggeri ZM, Kunicki TJ. Nucleotide polymorphisms in the alpha2 gene define multiple alleles that are associated with differences in platelet alpha2 beta1 density. Blood 1998; 92: 2382-8.
17. Moshfegh K, Wuillemin WA, Redondo M, Lammle B, Beer JH, Liechti-Gallati S, Meyer BJ. Association of two silent polymorphisms of platelet glycoprotein Ia/IIa receptor with risk of myocardial infarction: a case-control study. Lancet 1999; 353: 351-4.
18. Santoso S, Kunicki TJ, Kroll H, Haberbosch W, Gardemann A. Association of the platelet glycoprotein Ia C807T gene polymorphism with nonfatal myocardial infarction in younger patients. Blood 1999; 93: 2449-53.
19. Roest M, Banga JD, Grobbee DE, de Groot PG, Sixma JJ, Tempelman MJ, van der Schouw YT. Homozygosity for 807 T polymorphism in alpha(2) subunit of platelet alpha(2)beta(1) is associated with increased risk of cardiovascular mortality in high-risk women. Circulation 2000; 102: 1645-50.
20. Corral J, Gonzalez-Conejero R, Rivera J, Ortuno F, Aparicio P, Vicente V. Role of the 807 C/T polymorphism of the alpha2 gene in platelet GP Ia collagen receptor expression and function - effect in thromboembolic diseases. Thromb Haemost 1999; 81: 951-6.
21. Croft SA, Hampton KK, Sorrell JA, Steeds RP, Channer KS, Samani NJ, Daly ME. The GPIa C807T dimorphism associated with platelet collagen receptor density is not a risk factor for myocardial infarction. Br J Haematol 1999; 106: 771-6.
22. Zotz RB, Winkelmann BR, Nauck M, Giers G, Maruhn-Debowski B, Marz W, Scharf RE. Polymorphism of platelet membrane glycoprotein IIIa: human platelet antigen 1b (HPA-1b/PIA2) is an inherited risk factor for premature myocardial infarction in coronary artery disease. Thromb Haemost 1998; 79: 731-5.
23. Winkelmann BR, Marz W, Boehm BO, Zotz R, Hager J, Hellstern P, Senges J. Rationale and design of the LURIC study - a resource for functional genomics, pharmacogenomics and long-term prognosis of cardiovascular disease. Pharmacogenomics 2001; 2 (Suppl 1): 1-73.
24. Austen WG, Edwards JE, Frye RL, Gensini GG, Gott VL, Griffith LS, McGoon DC, Murphy ML, Roe BB. A reporting system on patients evaluated for coronary artery disease. Report of the Ad Hoc Committee for Grading of Coronary Artery Disease, Council on Cardiovascular Surgery, American Heart Association. Circulation 1975; 51: 5-40.
25. Little WC, Downes TR, Applegate RJ. The underlying coronary lesion in myocardial infarction: implications for coronary angiography. Clin Cardiol 1991; 14: 868-74.
26. Cox ID, Schwartzman RA, Atienza F, Brown SJ, Kaski JC. Angiographic progression in patients with angina pectoris and normal or near normal coronary angiograms who are restudied due to unstable symptoms. Eur Heart J 1998; 19: 1027-33.
27. Chen Q, Reis SE, Kammerer CM, McNamara DM, Holubkov R, Sharaf BL, Sopko G, Pauly DF, Bairey Merz CN, Kamboh MI. APOE polymorphism and angiographic coronary artery disease severity in the Women's Ischemia Syndrome Evaluation (WISE) study. Atherosclerosis 2003; 169: 159-67.
28. Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 1997; 20: 1183-97.
29. Unkelbach K, Kalb R, Santoso S, Kroll H, Mueller-Eckhardt C, Kiefel V. Genomic RFLP typing of human platelet alloantigens Zw(PIA), Ko, Bak and Br (HPA-1:2, 3:5). Br J Haematol 1995; 89: 169-76.
30. Corral J, Rivera J, Gonzalez-Conejero R, Vicente V. The number of platelet glycoprotein Ia molecules is associated with the genetically linked 807 C/T and HPA-5 polymorphisms. Transfusion 1999; 39: 372-8.
31. Nauck MS, Gierens H, Nauck MA, Marz W, Wieland H. Rapid genotyping of human platelet antigen 1 (HPA-1) with fluorophore-labelled hybridization probes on the LightCycler. Br J Haematol 1999; 105: 803-10.
32. Morita H, Kurihara H, Imai Y, Sugiyama T, Hamada C, Sakai E, Mori M, Nagai R. Lack of association between the platelet glycoprotein Ia C807T gene polymorphism and myocardial infarction in Japanese. An approach entailing melting curve analysis with specific fluorescent hybridization probes. Thromb Haemost 2001; 85: 226-30.
33. Atherosclerosis Thrombosis and Vascular Biology Italian Study Group. No evidence of association between prothrombotic gene polymorphisms and the development of acute myocardial infarction at a young age. Circulation 2003; 107: 1117-22.
34. Ross R. Atherosclerosis - an inflammatory disease. N Engl J Med 1999; 340: 115-26.
35. Nurden AT. Polymorphisms of platelet receptors as risk factors in coronary thrombosis. Eur Heart J 1996; 17: 1293-4.