Grade of chemotherapy-induced necrosis as a predictor of local and systemic control in 881 patients with non-metastatic osteosarcoma of the extremities treated with neoadjuvant chemotherapy in a single institution

European Journal of Cancer

Volumn 41, Issue 14, 2005, Pages 2079-2085

  Bacci, Gaetano ^a   Mercuri, Mario ^a   Longhi, Alessandra ^a   Ferrari, Stefano ^a   Bertoni, Franco ^a   Versari, Michela ^a   Picci, Piero ^a  

^a RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

Author keywords

Chemotherapy; Necrosis; Osteosarcoma; Prognosis

Indexed keywords

BLEOMYCIN; CISPLATIN; CYCLOPHOSPHAMIDE; DACTINOMYCIN; DOXORUBICIN; ETOPOSIDE; IFOSFAMIDE; METHOTREXATE;

ADJUVANT CHEMOTHERAPY; ADOLESCENT; ARTICLE; CANCER CHEMOTHERAPY; CANCER CONTROL; CANCER RECURRENCE; CANCER RELAPSE; CANCER SURGERY; CANCER SURVIVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; NECROSIS; OSTEOBLAST; OSTEOSARCOMA; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; PROGNOSIS; TELANGIECTASIA; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; BONE NEOPLASMS; CHEMOTHERAPY, ADJUVANT; DISEASE-FREE SURVIVAL; EXTREMITIES; FEMALE; HUMANS; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; OSTEOSARCOMA; PREOPERATIVE CARE; PROGNOSIS; TREATMENT OUTCOME;

EID: 25144482258     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2005.03.036     Document Type: Article

References (21)

1. G. Rosen, B. Caparros, and A.G. Huvos Preoperative chemotherapy for osteogenic sarcoma: selection of postoperative adjuvant chemotherapy based on response of the primary tumor to preoperative chemotherapy Cancer 49 1982 1221 1230
2. K. Winkler, G. Beron, and R. Kotz Neoadjuvant chemotherapy for osteogenic sarcoma: results of a cooperative German/Austrian study J Clin Oncol 2 1984 617 624
3. K. Winkler, G. Beron, and G. Delling Neoadjuvant chemotherapy for osteogenic sarcoma: results of a randomized cooperative trial (COSS-82) with salvage chemotherapy based on histological tumor response J Clin Oncol 6 1988 329 337
4. G. Bacci, P. Picci, and S. Ferrari Primary chemotherapy and delayed surgery for nonmetastatic osteosarcoma of the extremity Cancer 72 1993 3227 3238
5. G. Saeter, T.A. Alvegard, and I. Elomaa Treatment of osteosarcoma of the extremities with the T-10 protocol, with emphasis on the effects of preoperative chemotherapy with single-agent high-dose methotrexate: a Scandinavian Sarcoma Group study J Clin Oncol 9 1991 1766 1775
6. C. Kalifa, H. Razafindrakoto, and G. Vassal Chemotherapy in osteogenic sarcoma: the experience of the pediatric department of the Goustave Roussy Institute Cancer Treat Res 62 1993 347 349
7. R.S. Benjamin, S.P. Chawla, and C.H. Carrasco Preoperative chemotherapy for osteosarcoma with intravenous doxorubicin and intra-arterial cis-platinum Ann Oncol 2 1992 3 6
8. A.J. Provisor, L.J. Ettinger, and J.B. Nachman Treatment of nonmetastatic osteosarcoma of the extremity with preoperative and postoperative chemotherapy: a report from the Children's Cancer Group J Clin Oncol 15 1997 76 84
9. J.S. Wunder, G. Paulian, and A.G. Huvos The histological response to chemotherapy as a predictor of the oncological outcome of operative treatment of Ewing sarcoma J Bone Joint Surg Am 80 1998 1020 1033
10. S.S. Bielack, B. Kempf-Bielack, and G. Delling Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1702 patients treated on neoadjuvant Cooperative Osteosarcoma Study Group protocol J Clin Oncol 9 1991 1766 1775
11. A.G. Huvos, G. Rosen, and R.C. Marcove Pathologic aspects in 20 patients after treatment with chemotherapy, en bloc resection, and prosthetic bone replacement Arch Pathol Lab Med 101 1977 14 18
12. M. Salzer-Kuntschik, G. Brand, and G. Delling Bestimmung des morphologischen regressionsgrade nach chemotherapie bei malignen knochetumoren Pathologe 4 1983 135 141
13. A.G. Ayala, K.R. Raymond, and N. Jaffe The pathologist's role in diagnosis and treatment of osteosarcoma in children: controversies, current status and projections Hum Pathol 15 1984 258 266
14. G. Bacci, P. Picci, and P. Ruggieri Primary chemotherapy and delayed surgery (neoadjuvant chemotherapy) for osteosarcoma of the extremities. The Istituto Ortopedico Rizzoli experience in 127 patients treated preoperatively with intravenous methotrexate (high versus moderate doses) and intraarterial cisplatin Cancer 65 1990 2539 2553
15. A.M. Goorin, D.J. Schwartzentruber, and M. Devidas Presurgical chemotherapy compared with immediate surgery and adjuvant chemotherapy for nonmetastatic osteosarcoma: Pediatric Oncology Group Study POG-8651 J Clin Oncol 21 2003 1574 1580
16. W.F. Enneking, S. Spanier, and M.A. Goodman A system for the surgical staging of musculoskeletal sarcomas Clin Orthop 153 1980 106 120
17. P. Picci, G. Bacci, and M. Campanacci Histologic evaluation of necrosis in osteosarcoma induced by chemotherapy Cancer 56 1985 1515 1521
18. G. Bacci, S. Ferrari, and M. Mercuri Neoadjuvant chemotherapy for extremity osteosarcoma. Preliminary results of the Rizzoli's 4th Study Acta Oncol 37 1998 41 48
19. S. Ferrari, M. Mercuri, and P. Picci Nonmetastatic osteosarcoma of the extremity: results of a neoadjuvant chemotherapy protocol (IOR/OS-3) with high-dose methotrexate, intraarterial or intravenous cisplatin, doxorubicin, and salvage chemotherapy based on histologic tumor response Tumori 85 1999 458 464
20. G. Bacci, S. Ferrari, and A. Longhi High-dose ifosfamide in combination with high-dose methotrexate, doxorubicin and cisplatin in the neoadjuvant treatment of extremity osteosarcoma: preliminary results of an Italian Sarcoma Group/Scandinavian Sarcoma Group pilot study J Chemother 14 2002 198 206
21. G. Bacci, S. Ferrari, and F. Bertoni Long-term outcome for patients with nonmetastatic osteosarcoma of the extremity treated at Istituto Ortopedico Rizzoli accordino to the IOR/OS-2 protocol: an updated report J Clin Oncol 18 2000 4016 4027