Venlafaxine and serious withdrawal symptoms: Warning to drivers

MedGenMed Medscape General Medicine

Volumn 7, Issue 3, 2005, Pages

  Campagne, Daniel M ^a,b  

^a UNIVERSIDAD NACIONAL DE EDUCACIÓN A DISTANCIA   (Spain)

^b Clinica Bella Medica   (Spain)

Author keywords

Adrenaline; Discontinuance syndrome; Drivers; Seizures; Serotonin; Venlafaxine; Withdrawal

Indexed keywords

CHLORPROMAZINE; CITALOPRAM; CYPROHEPTADINE; DOBUPAL; FLUOXETINE; MAPROTILINE; PHENCYCLIDINE; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; VENLAFAXINE;

ANOREXIA; ANXIETY DISORDER; ARTICLE; CONFUSION; DATA BASE; DELIRIUM; DEPERSONALIZATION; DEPRESSION; DIARRHEA; DISEASE SEVERITY; DISORIENTATION; DIZZINESS; DOSE RESPONSE; DRIVER; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG HALF LIFE; DRUG SURVEILLANCE PROGRAM; DRUG WITHDRAWAL; EPILEPSY; FASCICULATION; FATIGUE; HEADACHE; HUMAN; HYPOMANIA; INSOMNIA; MEDLINE; MOOD DISORDER; NAUSEA; NIGHTMARE; NONHUMAN; OBSESSIVE COMPULSIVE DISORDER; OCCUPATIONAL HAZARD; PAIN; SEIZURE; SEROTONIN SYNDROME; SOCIAL PHOBIA; SOMNOLENCE; TREMOR; VERTIGO; VOMITING; WITHDRAWAL SYNDROME; XEROSTOMIA;

EID: 25144477379     PISSN: 15310132     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. US Food and Drug Administration: Letter to Wyeth Pharmaceuticals about violation of FDA regulations. March 18, 2004. Available at: http://www.fda.gov/cder/warn/2004/Effexor.pdf Accessed June 20, 2005.
2. Sternbach H. The serotonin syndrome. Am J Psychiatry. 1991;148:705-713.
3. Ellingrod VL, Perry PJ. Venlafaxine: a heterocyclic antidepressant. Am J Hosp Pharmacy. 1994;51:3033-3046.
4. Pinzani V, Ginies E, Robert L, Peyriere H, Abbar M, Blayac JP. Venlafaxine withdrawal syndrome: report of six cases and review of the literature. Rev Med Interne. 2000;21:282-284.
5. Parker G, Blennerhassett J. Withdrawal reactions associated with venlafaxine. Aust N Z J Psychiatry. 1998;32:291-294.
6. Reeves RR, Mack JE, Beddingfield JJ. Shock-like sensations during venlafaxine withdrawal. Pharmacotherapy. 2003;23:678-681.
7. van Noorden MS, Vergouwen AC, Koerselman GF. Delirium during withdrawal of venlafaxine. Ned Tijdschr Geneeskd. 2001;29:146:1236-1237.
8. Haddad PM, Devarajan S, Dursun SM. Antidepressant discontinuation withdrawal symptoms presenting as 'stroke'. J Psychopharmacol. 2001;15:139-141.
9. Houlihan DJ. Serotonin syndrome resulting from coadministration of tramadol, venlafaxine, and mirtazapine. Ann Pharmacother. 2004;38:411-413. Epub 2004 Jan 23
10. Jaunay E, Gaillac V, Guelfi JD. Serotonin syndrome. Which treatment and when? Presse Med. 2001;17:30:1695-1700.
11. Nisijima K, Shioda K, Yoshino T, Takano K, Kato S. Diazepam and chlormethiazole attenuate the development of hyperthermia in an animal model of the serotonin syndrome. Neurochem Int. 2003;43:155-164.
12. Pan JJ, Shen WW. Serotonin syndrome induced by low-dose venlafaxine. Ann Pharmacother. 2003;37:209-211.
13. Giorgi FS, Ferrucci M, Lazzeri G, et al. A damage to locus coeruleus neurons converts sporadis seizures into self-sustaining limbic status epilepticus. Eur J Neurosci. 2003;17:2593-2601.
14. Jobe PC, Dailey JW, Wernicke JF. A noradrenergic and serotonergic hypothesis of the linkage between epilepsy and affective disorders. Cit Rev Neurobiol. 1999;13:317-356.
15. Gutierrez MA, Stimmel GL, Aiso JY. Venlafaxine: a 2003 update. Clin Ther. 2003;25:2138-2154.
16. Sierra Santos L, Raigal Martin Y, Ortega Garcia A, Berriochoa Martinez de Pison C, Aparicio Jabalquinto G: Venlafaxina y sindrome de discontinuación. Atencion Primaria. 1999;24:617-618.
17. Selective serotonin re-uptake inhibitors and withdrawal reactions. WHO Drug Information. 1998;12:3, 136.