Ischemic brain damage after ketamine and xylazine treatment in a young laboratory monkey (Macaca fascicularis)

Contemporary Topics in Laboratory Animal Science

Volumn 44, Issue 5, 2005, Pages 19-24

  Yoshizawa, Katsuhiko ^a,b   Oishi, Yuji ^a   Matsumoto, Masahiro ^a   Nyska, Abraham ^b  

^a ASTELLAS PHARMA INC   (Japan)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANESTHETIC AGENT; CREATINE KINASE; KETAMINE; XYLAZINE;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; BLEEDING; BLOOD CHEMISTRY; BRAIN CORTEX; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN NUCLEUS; CEREBELLUM CORTEX; CEREBELLUM NUCLEUS; EPILEPSY; FEMALE; GENERAL ANESTHESIA; GLIOSIS; HEART ARREST; HEART MUSCLE HEMORRHAGIC NECROSIS; HEART MUSCLE NECROSIS; HIPPOCAMPUS; HISTOPATHOLOGY; HYPOTENSION; LENTIFORM NUCLEUS; LIVER HEMATOMA; LIVER SUBCAPSULAR HEMATOMA; MACACA; MEDULLA OBLONGATA; MONKEY; NERVE CELL NECROSIS; NEUROLOGIC DISEASE; NONHUMAN; NYSTAGMUS; OPISTHOTONUS; SEIZURE; TETANIC SPASM; VETERINARY MEDICINE;

ANESTHESIA; ANIMALS; BRAIN ISCHEMIA; CEREBELLAR CORTEX; CEREBRAL CORTEX; CORPUS STRIATUM; FEMALE; HIPPOCAMPUS; INJECTIONS, INTRAMUSCULAR; KETAMINE; MACACA FASCICULARIS; XYLAZINE;

ANIMALIA; MACACA FASCICULARIS;

EID: 25144473457     PISSN: 10600558     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Alfred, G. 2001. Ketamine, p. 346-347. In M. J. Martin, and J. M. Morriss (ed.), Goodman and Gilman's the pharmacological basis of therapeutics. McGraw-Hill, New York.
2. Auer, R. N. 1996. Effects of age and sex on N-methyl-D-aspartate antagonist-induced neuronal necrosis in rats. Stroke 27:743-746.
3. Barcikowska-Litwin, M., S. Krajewski, E. Dolinska, and J. Rafalowska. 1987. Lymphocytes within the infarct area in human brain. Neuropatol. Pol. 25:451-460.
4. Bree, M. M., I. Feller, and G. Corssen. 1967. Safety and tolerance of repeated anesthesia with CI581 (ketamine) in monkeys. Anesth. Analg. 46:596-600.
5. Brosnan-Watters, G., T. Ogimi, D. Ford, L. Tatekawa, D. Gilliam, E. J. Bilsky, and D. Nash. 2000. Differential effects of MK-801 on cerebrocortical neuronal injury in C57BL/6J, NSA, and ICR mice. Prog. Neuropsychopharmacol. Biol. Psychiatry 24:925-938.
6. Casillas, V. F., M. A. Amendola, A. Gascue, N. Pinnar, F. U. Levi, and J. M. Perez. 2000. Imaging of nontraumatic hemorrhagic hepatic lesions. Radiographics 20:367-378.
7. Chen, T. S., F. C. Yeh, Y. P. Chou, and H. I. Chen. 1984. Effects of ketamine on the circulatory functions and body tissue oxygenation in dogs under normal and hypovolemic conditions, Proc. Natl. Sci. Counc. Repub. China B 8:168-176.
8. Duncan, J. R. and K. W. Prasse. 1977. Veterinary laboratory medicine. Clinical pathology. Iowa State University Press, Ames, Iowa.
9. Fisher, M. 2004. Anaphylaxis to anaesthetic drugs. Novartis Found. Symp. 257:193-202.
10. Fisher, M. M. and G. S. Doig. 2004. Prevention of anaphylactic reactions to anaesthetic drugs. Drug Saf. 27:393-410.
11. Grone, A., S. Alldinger, and W. Baumgartner. 2000. Interleukin-1β, -6, -12 and tumor necrosis factor-α expression in brains of dogs with canine distemper virus infection. J. Neuroimmunol. 110:20-30.
12. 11C] ketamine in the rhesus monkey studied by positron emission tomography (PET). Nucl. Med. Biol. 21:927-934.
13. Hartvig, P., J. Valtysson, K. J. Lindner, J. Kristensen, R. Karlsten, L. L. Gustafsson, J. Persson, J. O. Svesson, I. Oye, G. Antoni, G. Westerberg, and B. Langstrom. 1995. Central nervous system effects of subdissociative doses of (S)-ketamine are related to plasma and brain concentrations measured with positron emission tomography in healthy volunteers. Clin. Pharmacol. Ther. 58:165-173.
14. Hoffman, U., C. M. Meister, K. Golle, and M. Zschiesche. 2001. Severe intoxication with the veterinary tranquilizer xylazine in humans. J. Anal. Toxicol. 25:245-249.
15. Javitt, D. C. 2000. Phencyclidine, p. 979-984. In P. S. Spencer and H. H. Schauburg (ed.), Experimental and clinical neurotoxicology, 2nd ed. CRC Press, New York.
16. Johnson, K. M., M. Phillips, C. Wang, and G. A. Kevetter. 1998. Chronic phencyclidine induces behavioral sensitization and apoptotic cell death in the olfactory and piriform cortex. J. Neurosci. Res. 52:709-722.
17. Kawashima, Y., N. Seo, K. Morita, Y. Iwao, K. Irita, K. Tsuzaki, Y. Tanaka, Y. Shiraishi, Y. Nakao, Y. Tosaki, Y. Goto, T. Kobayashi, S. Domi, and H. Obara. 2002. Annual study of anesthesia-related mortality and morbidity in the year 2000 in Japan. Report of Japanese Society of Anesthesiologists Committee on Operating Room Safety. Masui 51:1032-1047 (text in Japanese, abstract in English).
18. Leifer, D. and N. W. Kowall. 1993. Immunohistochemical patterns of selective cellular vulnerability in human cerebral ischemia. J. Neurol. Sci. 119:217-228.
19. Marini, R. P., X. Li, N. K. Harpster, and C. Dangler. 1999. Cardiovascular pathology possibly associated with ketamine/xylazine anesthesia in Dutch Belted tabbits. Lab. Anim. Sci. 49:153-160.
20. Meldrum, B. 1978. Physiological changes during prolonged seizures and epileptic brain damage. Neuropadiatrie 9:203-212.
21. Mittleman, R. E., W. L. Hearn, and G. W. Hime. 1997. Xylazine toxicity: literature review and report of two cases. J. Forensic Sci. 43:400-402.
22. Moss, J. 1995. Muscle relaxants and histamine release. Acta Anaesthesiol. Scand. Suppl. 106:7-12.
23. Naccarato, E. F. and W. S. Hunter. 1979. Anaesthetic effects of various ratios of ketamine and xylazine in rhesus monkeys (Macacca mulatta). Lab Anim. 13:317-319.
24. Nakamura, S., W. Kiatipattanasakul, H. Nakayama, F. Ono, I. Sakakibara, Y. Yoshikawa, N. Goto, and K. Doi. 1996. Immunohistochemical characteristics of the constituents of senile plaques and amyloid angiopathy in aged cynomolgus monkeys. J. Med. Primatol. 25:294-300.
25. Newman, D. H., M. M. Azer, R. D. Pitetti, R. D., and S. Singh. 2003. When is a patient safe for discharge after procedural sedation? The timing of adverse effect events in 1,367 pediatric procedural sedations. Ann. Emerg. Med. 42:627-635.
26. Olney, J. W., J. Labruyere, and M. T. Price. 1989. Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. Science 244:1360-1362.
27. Palmer, A. C. and P. G. Walker. 1970. The neuropathological effects of cardiac arrest in animals: a study of five cases. J. Small Anim. Pract. 11:779-791.
28. Parke-Davis Company. 1969. Ketamine hydrochloride (Ketalar). Clin. Pharmacol. Ther. 11:777-780.
29. Pitetti, R. D., S. Singh, and M. C. Pierce. 2003. Safe and efficacious use of procedural sedation and analgesia by nonanesthesiologists in a pediatric emergency department. Arch. Pediatr. Adolesc. Med. 157:1090-1096.
30. Reutlinger, R. A., A. A. Karl, and S. I. Vinal. 1980. Effects of ketamine HCl-xylazine HCl combination on cardiovascular and pulmonary values of the rhesus macaque (Macaca mulatta). Am. J. Vet. Res. 41:1453-1457.
31. Rossoff, I. S. 2002. Ketamine, p. 586-587. In I. S. Rossoff (ed,), Encyclopedia of clinical toxicology. A comprehensive guide and reference to the toxicology of prescription and OTC drugs, chemicals, herbals, plants, fungi, marine life, reptiles and insect venoms, food ingredients, clothing, and environmental toxins. CRC Press, New York.
32. Safi, F., S. Weiner, B. Poch, A. Schwarz, and H. G. Beger. 1999. Surgical management of liver rupture. Chirurg 70:253-258.
33. Scallet, A. C., L. C. Schmued, W. Slikker, Jr., N. Grunberg, P. J. Faustino, H. Davis, D. Letter, P. S. Pine, F. Sistare, and J. P. Hanig. 2004. Developmental neurotoxicity of ketamine: morphometric confirmation, exposure parameters, and multiple fluorescent labeling of apoptotic neurons. Toxicol. Sci. 81:364-370.
34. Schroeter, M., S. Jander, O. W Witte, and G. Stoll. 1994. Local immune responses in the rat cerebral cortex after middle cerebral artery occlusion. J. Neuroimmunol. 55:195-203.
35. Sedlakova, I., M. Podholova, and J. Tosner. 2003. Subcapsular hepatic hematoma. Int. J. Gynaecol. Obstet. 81:299-300.
36. Selkoe, D. J. and R. E. Myers. 1979. Neurologic and cardiovascular effects of hypotension in the monkey. Stroke 10:147-157.
37. Silver, J. R. and P. H. Buxton. Spinal stroke. Brain 97:539-550.
38. Singbartl, G., D. Langrehr, and R. Neuhaus. 1975. Ketamine: a cardiovascular stimulating agent with direct cardiodepressant action (author's translation). Prakt. Anaesth. 10:335-344.
39. Singh, U., J. R. Silver, and N. C. Welply. Hypotensive infarction of the spinal cord. Paraplegia 32:314-322.
40. Steen, P. A. and J. D. Michenfelder. 1979. Neurotoxicity of anesthetics. Anesthesiology 50:437-453.
41. Streit, W. J. and G. W. Kretzberg. 1987. Lectin binding by resting and reactive microglia. J. Neurocytol. 16:249-260.
42. Summers, B. A., J. F. Cummings, and A. de Lahunta. 1995. Seizures and cerebral necrosis, p. 244-246. In L. Duncan (ed.), Veterinary neuropathology. Mosby Year Book, St. Louis.
43. Tomioka, C., K. Nishioka, and K. Kogure. 1992. Absence of early destructive changes of cytoskeletal proteins after transient ischemia in the rat. Brain Res. 586:352-357.
44. Zeiss, C. J., N. H. Shomer, and F. R. Homberger. 2001. Hypotensive infarction of the spinal cord in a rhesus macaque (Macaca multta). Vet. Pathol. 38:105-108.