Mechanism of the solution oxidation of rofecoxib under alkaline conditions

Pharmaceutical Research

Volumn 22, Issue 10, 2005, Pages 1716-1726

  Harmon, Paul A ^a   Biffar, Stephen ^a   Pitzenberger, Steven M ^a   Reed, Robert A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Base catalyzed; Enolate ion; Mechanism; Oxidation; Rofecoxib; Stability

Indexed keywords

ACETONITRILE; ACID ANHYDRIDE; ALCOHOL; ALDEHYDE; BUFFER; CARBON; DICARBOXYLIC ACID; FORMALDEHYDE; FURANONE DERIVATIVE; GAMMA LACTONE DERIVATIVE; HYDROGEN PEROXIDE; HYDROPEROXIDE DERIVATIVE; HYDROXYFURANONE; ION; METHYLENE CARBON; OXYGEN; PHOSPHATE; ROFECOXIB; TRIPHENYLPHOSPHINE; TRIPHENYLPHOSPHINE OXIDE; UNCLASSIFIED DRUG; WATER;

ALKALINITY; AQUEOUS SOLUTION; ARTICLE; ATOM; CHEMICAL BOND; CORRELATION ANALYSIS; DRUG OXIDATION; EXPOSURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULE; NUCLEAR MAGNETIC RESONANCE; PH; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REACTION ANALYSIS; TIME; WATER CONTENT;

ALKALIES; DRUG STABILITY; FURANS; HYDROGEN PEROXIDE; HYDROGEN-ION CONCENTRATION; LACTONES; OXIDATION-REDUCTION; SOLUTIONS; SULFONES; TIME FACTORS;

EID: 25144453274     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-005-6947-z     Document Type: Article

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