Protective effect of ginkgo biloba against gossypol-induced apoptosis in human lymphocytes

Cell Biology International

Volumn 29, Issue 8, 2005, Pages 717-720

  Ergun, Ufuk ^a   Yurtcu, Erkan ^b   Ergun, Mehmet Ali ^b  

^a ANKARA TRAINING AND RESEARCH HOSPITAL   (Turkey)

^b GAZI UNIVERSITY   (Turkey)

Author keywords

Apoptosis; Ginkgo biloba (EGb 761); Gossypol; Human lymphocyte

Indexed keywords

GINKGO BILOBA EXTRACT; GOSSYPOL;

APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DRUG EFFECT; GINKGO BILOBA; HUMAN; HUMAN CELL; LYMPHOCYTE; T LYMPHOCYTE;

APOPTOSIS; CELLS, CULTURED; CONTRACEPTIVE AGENTS, MALE; DNA; GINKGO BILOBA; GOSSYPOL; HUMANS; LYMPHOCYTES; PLANT EXTRACTS; PROTECTIVE AGENTS;

GINKGO BILOBA;

EID: 25144451397     PISSN: 10656995     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellbi.2005.04.005     Document Type: Article

References (19)

1. B. Ahlemeyer, and J. Krieglstein Pharmacological studies supporting the therapeutic use of Ginkgo biloba extract for Alzheimer's disease Pharmacopsychiatry 36 2003 8 14
2. R. Barhoumi, and R.C. Burghardt Kinetic analysis of the chronology of patulin- and gossypol-induced cytotoxicity in vitro Fundam Appl Toxicol 30 1996 290 297
3. S. Bastianetto, C. Ramassamy, S. Dore, Y. Christen, J. Poirier, and R. Quirion The Ginkgo biloba extract (EGb 761) protects hippocampal neurons against cell death induced by beta-amyloid Eur J Neurosci 12 2000 1882 1890
4. C.C. Benz, M.A. Keniry, J.M. Ford, A.J. Townsend, F.W. Cox, and S. Palayoor Biochemical correlates of the antitumor and antimitochondrial properties of gossypol enantiomers Mol Pharmacol 37 1990 840 847
5. C. Chen, T. Wei, Z. Gao, B. Zhao, J. Hou, and H. Xu Different effects of the constituents of EGb761 on apoptosis in rat cerebellar granule cells induced by hydroxyl radicals Biochem Mol Biol Int 47 1999 397 405
6. S.M. Cheng, S.P. Yang, L.J. Ho, T.P. Tsao, T.Y. Juan, and D.M. Chang Down-regulation of c-jun N-terminal kinase-activator protein-1 signaling pathway by Ginkgo biloba extract in human peripheral blood T cells Biochem Pharmacol 66 2003 679 689
7. J. Gong, F. Traganos, and Z. Darzynkiewicz A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry Anal Biochem 218 1994 314 319
8. D.X. Hou, T. Uto, X. Tong, T. Takeshita, S. Tanigawa, and I. Imamura Involvement of reactive oxygen species-independent mitochondrial pathway in gossypol-induced apoptosis Arch Biochem Biophys 428 2004 179 187
9. W.D. Jarvis, A.J. Turner, L.F. Povirk, R.S. Traylor, and S. Grant Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C Cancer Res 54 1994 1707 1714
10. P.L. Le Bars, M.M. Katz, N. Berman, T.M. Itil, A.M. Freedman, and A.F. Schatzberg A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study Group JAMA 278 1997 1327 1332
11. M. Monte, L.E. Davel, and E.S. de Lustig Inhibition of lymphocyte-induced angiogenesis by free radical scavengers Free Radic Biol Med 17 1994 259 266
12. Y. Ni, B. Zhao, J. Hou, and W. Xin Preventive effect of Ginkgo biloba extract on apoptosis in rat cerebellar neuronal cells induced by hydroxyl radicals Neurosci Lett 214 1996 115 118
13. K. Schindowski, S. Leutner, S. Kressmann, A. Eckert, and W.E. Muller Age-related increase of oxidative stress-induced apoptosis in mice prevention by Ginkgo biloba extract (EGb761) J Neural Transm 108 2001 969 978
14. H. Wang, and T.B. Ng Ginkbilobin, a novel antifungal protein from Ginkgo biloba seeds with sequence similarity to embryo-abundant protein Biochem Biophys Res Commun 279 2000 407 411
15. X. Wang, J. Wang, S.C. Wong, L.S. Chow, J.M. Nicholls, and Y.C. Wong Cytotoxic effect of gossypol on colon carcinoma cells Life Sci 67 2000 2663 2671
16. T. Wei, Y. Ni, J. Hou, C. Chen, B. Zhao, and W. Xin Hydrogen peroxide-induced oxidative damage and apoptosis in cerebellar granule cells: protection by Ginkgo biloba extract Pharmacol Res 41 2000 427 433
17. W. Xin, T. Wei, C. Chen, Y. Ni, B. Zhao, and J. Hou Mechanisms of apoptosis in rat cerebellar granule cells induced by hydroxyl radicals and the effects of EGb761 and its constituents Toxicology 148 2000 103 110
18. E. Yurtcu, M.A. Ergun, and A. Menevse Apoptotic effect of gossypol on human lymphocytes Cell Biol Int 27 2003 791 794
19. L.J. Zhou, and X.Z. Zhu Reactive oxygen species-induced apoptosis in PC12 cells and protective effect of bilobalide J Pharmacol Exp Ther 293 2000 982 988