Case 28-2005: A 42-year-old man with weight loss, weakness, and a rash

New England Journal of Medicine

Volumn 353, Issue 11, 2005, Pages 1148-1157

  Wolf, Myles ^a,c   Rose, Henry ^b   Smith, R Neal ^a,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BERKSHIRE MEDICAL CENTER   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE KIDNEY FAILURE; ADULT; ANAMNESIS; ARTICLE; CASE REPORT; CHURG STRAUSS SYNDROME; CLINICAL FEATURE; CYTOPATHOLOGY; DIAGNOSTIC APPROACH ROUTE; DIAGNOSTIC IMAGING; DIAGNOSTIC TEST; DIFFERENTIAL DIAGNOSIS; EOSINOPHILIA; HUMAN; INTERSTITIAL NEPHRITIS; KIDNEY BIOPSY; LABORATORY TEST; MALE; MEDICAL EXAMINATION; NEUROLOGIC DISEASE; PRIORITY JOURNAL; PURPURA; RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS; ASTHMA; BLOOD; BLOOD ANALYSIS; CLINICAL OBSERVATION; CLINICAL STUDY; DIAGNOSIS; GLOMERULONEPHRITIS; KIDNEY; MUSCLE WEAKNESS; PATHOLOGY; RASH; WEIGHT REDUCTION;

GLUCOCORTICOID; NEUTROPHIL CYTOPLASMIC ANTIBODY;

ADULT; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; ASTHMA; BLOOD CHEMICAL ANALYSIS; CHURG-STRAUSS SYNDROME; DIAGNOSIS, DIFFERENTIAL; EOSINOPHILIA; EXANTHEMA; GLOMERULONEPHRITIS; GLUCOCORTICOIDS; HUMANS; KIDNEY; KIDNEY FAILURE, ACUTE; MALE; MUSCLE WEAKNESS; NEPHRITIS, INTERSTITIAL; PURPURA; WEIGHT LOSS;

EID: 24944561956     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJMcpc059022     Document Type: Article

References (21)

1. Jennette JC, Falk RJ. Small-vessel vasculitis. N Engl J Med 1997;337:1512-23.
2. Trojaborg W. Acute and chronic neuropathies: new aspects of Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy, an overview and an update. Electroencephalogr Clin Neurophysiol 1998;107:303-16.
3. Rothenberg ME. Eosinophilia. N Engl J Med 1998;338:1592-600.
4. Cools J, DeAngelo DJ, Gotlib J, et al. A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N Engl J Med 2003;348:1201-14.
5. Thadhani R, Pascual M, Bonventre JV. Acute renal failure. N Engl J Med 1996;334:1448-60.
6. Hricik DE, Chung-Park M, Sedor JR. Glomerulonephritis. N Engl J Med 1998;339:888-99.
7. Noth I, Strek ME, Leff AR. Churg-Strauss syndrome. Lancet 2003;361:587-94.
8. Wechsler ME, Pauwels R, Drazen JM. Leukotriene modifiers and Churg-Strauss syndrome: adverse effect or response to corticosteroid withdrawal? Drug Saf 1999;21:241-51.
9. Wechsler ME, Finn D, Gunawardena D, et al. Churg-Strauss syndrome in patients receiving montelukast as treatment for asthma. Chest 2000;117:708-13.
10. Specks U. Diffuse alveolar hemorrhage syndromes. Curr Opin Rheumatol 2001;13:12-7.
11. Niles JL, Bottinger EP, Saurina GR, et al. The syndrome of lung hemorrhage and nephritis is usually an ANCA-associated condition. Arch Intern Med 1996;156:440-5.
12. Seo P, Stone JH. The antineutrophil cytoplasmic antibody-associated vasculitides. Am J Med 2004;117:39-50.
13. Niles JL. Antineutrophil cytoplasmic antibodies in the classification of vasculitis. Annu Rev Med 1996;47:303-13.
14. Jennette JC, Wilkman AS, Falk RJ. Antineutrophil cytoplasmic autoantibody-associated glomerulonephritis and vasculitis. Am J Pathol 1989;135:921-30.
15. Churg J, Strauss L. Allergic granulomatosis, allergic angiitis, and periarteritis nodosa. Am J Pathol 1951;27:277-301.
16. Clutterbuck EJ, Evans DJ, Pusey CD. Renal involvement in Churg-Strauss syndrome. Nephrol Dial Transplant 1990;5:161-7.
17. D'Agati V, Chander P, Nash M, Mancilla-Jimenez R. Idiopathic microscopic polyarteritis nodosa: ultrastructural observations on the renal vascular and glomerular lesions. Am J Kidney Dis 1986;7:95-110.
18. Koss MN, Antonovych T, Hochholzer L. Allergic granulomatosis (Churg-Strauss syndrome). Am J Surg Pathol 1981;5:21-8.
19. Stone JH, Talor M, Stebbing J, et al. Test characteristics of immunofluorescence and ELISA tests in 856 consecutive patients with possible ANCA-associated conditions. Arthritis Care Res 2000;13:424-34.
20. Choi HK, Liu S, Merkel PA, Colditz GA, Niles JL. Diagnostic performance of antineutrophil cytoplasmic antibody tests for idiopathic vasculitides: metaanalysis with a focus on antimyeloperoxidase antibodies. J Rheumatol 2001;28:1584-90.
21. Han WK, Choi HK, Roth RM, McCluskey RT, Niles JL. Serial ANCA titers: useful tool for prevention of relapses in ANCA-associated vasculitis. Kidney Int 2003;63:1079-85.