Tetraparesis associated with colchicine is probably due to inhibition by verapamil of the P-glycoprotein efflux pump in the blood-brain barrier

British Medical Journal

Volumn 331, Issue 7517, 2005, Pages 613-

  Tröger, Uwe ^a   Lins, Hartmut ^a   Scherrmann, Jean M ^b   Wallesch, Claus Werner ^a   Bode Böger, Stefanie M ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

COLCHICINE; GLYCOPROTEIN P; NORVERAPAMIL; VERAPAMIL;

AGED; ANAMNESIS; ARTICLE; BLOOD BRAIN BARRIER; CASE REPORT; CEREBROSPINAL FLUID ANALYSIS; CLINICAL EXAMINATION; DRUG INHIBITION; ELECTROMYOGRAPHY; GOUT; HUMAN; LABORATORY TEST; MALE; MUSCLE BIOPSY; NEUROMUSCULAR DISEASE; PRIORITY JOURNAL; PROTEIN CEREBROSPINAL FLUID LEVEL; PROTEIN TRANSPORT; QUADRIPLEGIA; SELF MEDICATION; TACHYCARDIA; BLOOD; CEREBROSPINAL FLUID; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; FEMALE; METABOLISM; TRANSPORT AT THE CELLULAR LEVEL;

AGED; AGED, 80 AND OVER; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; COLCHICINE; FEMALE; HUMANS; P-GLYCOPROTEIN; QUADRIPLEGIA; VERAPAMIL;

EID: 24944550916     PISSN: 09598146     EISSN: None     Source Type: Journal    
DOI: 10.1136/bmj.38568.639688.F7     Document Type: Article

References (4)

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4. Drion N, Risede P, Cholet N, Chanez C, Scherrmann JM. Role of P-170 glycoprotein in colchicine brain uptake. J Neurosci Res 1997;49:80-8.