Metallation of the transition-state inhibitor N-methyl mesoporphyrin by ferrochelatase: Implications for the catalytic reaction mechanism

Journal of Molecular Biology

Volumn 352, Issue 5, 2005, Pages 1081-1090

  Shipovskov, Stepan ^a   Karlberg, Tobias ^a   Fodje, Michel ^a   Hansson, Mattias D ^a   Ferreira, Gloria C ^b   Hansson, Mats ^a   Reimann, Curt T ^a   Al Karadaghi, Salam ^a  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Catalysis; Heme synthesis; Metal specificity; Metallation; Porphyrin distortion

Indexed keywords

COPPER; CROWN ETHER; FERROCHELATASE; HEME; MESOPORPHYRIN; PROTOPORPHYRIN; ZINC;

ACCELERATION; ARTICLE; CATALYSIS; CRYSTALLOGRAPHY; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME RELEASE; ENZYME STRUCTURE; ENZYME SUBSTRATE; HEME SYNTHESIS; LIGAND BINDING; METAL BINDING; METALLATION; PHASE TRANSITION; PRIORITY JOURNAL;

EID: 24944548315     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2005.08.002     Document Type: Article

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