Validation of the plasma half-life of 11α-deuterium cortisol as a sensitive index for the analysis of human 11β-HSD2 activity in vivo

Steroids

Volumn 70, Issue 12, 2005, Pages 811-816

  Kasuya, Yasuji ^a   Yokokawa, Akitimo ^a   Hamura, Kouichi ^a   Shibasaki, Hiromi ^a   Furuta, Takashi ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

11 HSD2 catalyzed conversion of cortisol to cortisone; Gas chromatography mass spectrometry; Stable isotope methodology

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; CARBON 13; CORTISONE DERIVATIVE; DEUTERIUM; GLYCYRRHIZIC ACID; HYDROCORTISONE DERIVATIVE; STABLE ISOTOPE;

ADULT; ARTICLE; BIOEQUIVALENCE; CONTROLLED STUDY; DRUG ELIMINATION; DRUG HALF LIFE; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; ISOTOPE LABELING; MALE; MEDICAL ASSESSMENT; NORMAL HUMAN; SENSITIVITY ANALYSIS; VALIDATION PROCESS;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2; ADMINISTRATION, ORAL; ADULT; ANTI-INFLAMMATORY AGENTS; BIOTRANSFORMATION; DEUTERIUM; HUMANS; HYDROCORTISONE; MALE;

EID: 24944530005     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.steroids.2005.05.004     Document Type: Article

References (19)

1. J.A. Whitworth, P.M. Stewart, D. Burt, S.M. Atherden, and C.R.W. Edwards The kidney is the major site of cortisone production in man Clin Endocrinol 31 1989 355 361
2. Z.S. Krozowski, and J.W. Funder Renal mineralocorticoid receptors and hippocampal corticosterone-binding species have identical intrinsic steroid specificity Proc Natl Acad Sci USA 80 1983 6056 6060
3. J.L. Arriza, C. Weinberger, G. Cerelli, T.M. Glaser, B.K. Handelin, and D.E. Housman Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor Science 237 1987 268 275
4. L. Hellman, F. Nakada, B. Zumoff, D. Fukushima, H.L. Bradlow, and T.F. Gallagher Renal capture and oxidation of cortisol in man J Clin Endocrinol Metab 33 1971 52 62
5. C.R.W. Edwards, P.M. Stewart, D. Burt, L. Brett, M.A. McIntyre, and W.S. Sutanto Localisation of 11β-hydroxysteroid dehydrogenase: tissue specific protector of the mineralocorticoid receptor Lancet ii 1988 986 989
6. J.W. Funder, P.T. Pearce, R. Smith, and A.I. Smith Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated Science 242 1988 583 585
7. P.C. White, T. Mune, and A.K. Agarwal 11β-Hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess Endocr Rev 18 1997 135 156
8. P.M. Stewart Cortisol as a mineralocorticoid in human disease J Steroid Biochem Mol Biol 69 1999 408-403
9. P. Ferrari, and Z. Krozowski Role of the 11β-hydroxysteroid dehydrogenase type 2 in blood pressure regulation Kidney Int 57 2000 1374 1381
10. A. Odermatt, P. Arnold, and F.J. Frey The intracellular localization of the mineralocorticoid receptor is regulated by 11β-hydroxysteroid dehydrogenase type 2 J Biol Chem 276 2001 28484 28492
11. M. Quinkler, and P.M. Stewart Hypertension and the cortisol-cortisone shuttle J Clin Endocrinol Metab 88 2003 2384 2392
12. 1 to a human subject Steroids 68 2003 167 176
13. Y. Kasuya, A. Yokokawa, S. Takashima, H. Shibasaki, and T. Furuta Use of 11β-deuterium labeled cortisol as a tracer for assessing reduced 11β-HSD activity in vivo following glycyrrhetinic acid ingestion in a human subject Steroids 70 2005 117 125
14. 13C for study of cortisol metabolism in humans Steroids 65 2000 180 189
15. 13C-labeled cortisols and cortisones in human plasma by stable isotope dilution mass spectrometry J Chromatogr B 738 2000 119 127
16. D.J. Morris, A.S. Brem, A. Ge, P.H. Jellinck, R.R. Sakai, and M.P. Hardy The functional roles of 11β-HSD1: vascular tissue, testis and brain Mol Cell Endocrinol 203 2003 1 12
17. S. Ulick, L.S. Levine, P. Gunczler, G. Zanconato, L.C. Ramirez, and W. Rayh A syndrome of apparent mineralocorticoid excess associated with defects in the peripheral metabolism of cortisol J Clin Endocrinol Metab 49 1979 757 764
18. P.M. Stewart, J.E. Corrie, C.H. Shackleton, and C.R. Edwards Syndrome of apparent mineralocorticoid excess. A defect in the cortisol-cortisone shuttle J Clin Invest 82 1988 340 349
19. B.R. Walker, P.M. Stewart, C.H. Shackleton, P.L. Padfield, and CR.W. Edwards Deficient inactivation of cortisol by 11β-hydroxysteroid dehydrogenase in essential hypertension Clin Endocrinol 39 1993 221 227