Development of acute tolerance to the EEG effect of propofol in rats

British Journal of Anaesthesia

Volumn 95, Issue 3, 2005, Pages 367-371

  Ihmsen, Harald ^a   Schywalsky, M ^a   Tzabazis, A ^a   Schwilden, H ^a  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

Anaesthetic techniques, closed loop controlled infusion; Anaesthetics i.v., propofol; Model, rat; Monitoring, electroencephalography, median frequency; Pharmacology, acute tolerance

Indexed keywords

KETAMINE; PANCURONIUM; PROPOFOL; INTRAVENOUS ANESTHETIC AGENT;

ANESTHESIA INDUCTION; ANESTHESIA MECHANISM; ANIMAL EXPERIMENT; ARTICLE; ARTIFICIAL VENTILATION; BLOOD GAS ANALYSIS; BLOOD PRESSURE MONITORING; BLOOD SAMPLING; DRUG BLOOD LEVEL; DRUG TOLERANCE; ELECTROENCEPHALOGRAM; ENTROPY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPNOSIS; INTRAVENOUS ANESTHESIA; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; RAT; RAT STRAIN; ANIMAL; BLOOD; DOSE RESPONSE; DRUG DELIVERY SYSTEM; DRUG EFFECT; ELECTROENCEPHALOGRAPHY; SPRAGUE DAWLEY RAT;

ANESTHETICS, INTRAVENOUS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; DRUG TOLERANCE; ELECTROENCEPHALOGRAPHY; MALE; PROPOFOL; RATS; RATS, SPRAGUE-DAWLEY;

EID: 24944529637     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aei179     Document Type: Article

References (15)

1. Ihmsen H, Tzabazis A, Schywalsky M, Schwilden H. Propofol in rats: testing for non-linear pharmacokinetics and modelling acute tolerance to EEG effects. Eur J Anaesthesiol 2002; 19: 177-88
2. Tzabazis A, Ihmsen H, Schywalsky M, Schwilden H. EEG-controlled closed-loop dosing of propofol in rats. Br J Anaesth 2004; 92: 564-9
3. Schywalsky M, Ihmsen H, Tzabazis A, et al. Pharmacokinetics and pharmacodynamics of the new propofol prodrug GPI 15715 in rats. Eur J Anaesthesiol 2003; 20: 182-90
4. Bruhn J, Ropcke H, Hoeft A. Approximate entropy as an electroencephalographic measure of anesthetic drug effect during desflurane anesthesia. Anesthesiology 2000; 92: 715-26
5. Varvel JR, Donoho DL, Shafer SL. Measuring the predictive performance of computer-controlled infusion pumps. J Pharmacokinet Biopharm 1992; 20: 63-94
6. Greenblatt DJ, Shader RI. Dependence, tolerance, and addiction to benzodiazepines: Clinical and pharmacokinetic considerations. Drug Metab Rev 1978; 8: 13-28
7. Cockshott ID, Douglas EJ, Plummer GF, Simons PJ. The pharmacokinetics of propofol in laboratory animals. Xenobiotica 1992; 22: 369-75
8. Fassoulaki A, Farinotti R, Mantz J, Desmonts JM. Does tolerance develop to the anaesthetic effects of propofol in rats? Br J Anaesth 1994; 72: 127-8
9. Larsson JE, Wahlstrom G. Age-dependent development of acute tolerance to propofol and its distribution in a pharmacokinetic compartment-independent rat model. Acta Anaesthesiol Scand 1996; 40: 734-40
10. Setlock MA, Palmisano BW, Berens RJ, Rosner DR, Troshynski TJ, Murray KJ. Tolerance to propofol generally does not develop in pediatric patients undergoing radiation therapy. Anesthesiology 1996; 85: 207-9
11. Mayhew JF, Abouleish AE. Lack of tolerance to propofol. Anesthesiology 1996; 85: 1209
12. Deer TR, Rich GF. Propofol tolerance in a pediatric patient. Anesthesiology 1992; 77: 828-9
13. Albrecht S, Ihmsen H, Suchodolski K, Frenkel C, Schuttler J. Analgo-sedation in intensive care: A quantitative, EEG-based trial with propofol 1% and 2%. Anaesthesist 1999; 48: 794-801
14. Buckley PM. Propofol in patients needing long-term sedation in intensive care: An assessment of the development of tolerance. A pilot study. Intensive Care Med 1997; 23: 969-74
15. Bateson AN. Basic pharmacologic mechanisms involved in benzodiazepine tolerance and withdrawal. Curr Pharm Des 2002; 8: 5-21