Higher venous bicarbonate concentration associated with hypoxemia, not acute mountain sickness, after ascent to moderate altitude

Journal of Travel Medicine

Volumn 12, Issue 4, 2005, Pages 184-189

  Cumbo, Thomas A ^a,h   Braude, Darren ^b   Basnyat, Buddha ^c,d   Rabinowitz, Lisa ^b   Lescano, Andres G ^e   Shah, Mark B ^b   Radder, Destin J ^f   Bashyal, Govind ^c,d   Gambert, Steven R ^a,g  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^c NEPAL INTERNATIONAL CLINIC   (Nepal)

^d Tribuvan Medical School   (Nepal)

^e JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^f Himalayan Rescue Association   (Nepal)

^g Sinai Hospital   (United States)

^h Sinai Hospital ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAZOLAMIDE; BICARBONATE; STEROID;

ACUTE DISEASE; ADULT; ALKALOSIS; ALTITUDE DISEASE; ANAMNESIS; ARTICLE; BICARBONATE BLOOD LEVEL; BLOOD SAMPLING; CLINICAL ARTICLE; CLINICAL EXAMINATION; CONTROLLED STUDY; FEMALE; HUMAN; HYPOXEMIA; MALE; NEPAL; OXYGEN SATURATION; SCORING SYSTEM;

EID: 24944520363     PISSN: 11951982     EISSN: None     Source Type: Journal    
DOI: 10.2310/7060.2005.12403     Document Type: Article

References (25)

1. Hackett PH, Roach RC. High altitude illness. N Engl J Med: 2001; 345:107-114.
2. Honigman B, Theis MK, Koziol-McLain J, et al. Acute mountain sickness in a general tourist population at moderate altitudes (published erratum appears in Ann Intern Med 1994; 120:698). Ann Intern Med 1993; 118:587-592.
3. Dean AG, Yip R, Hoffmann RE. High incidence of mild acute mountain sickness in conference attendees at 10,000 foot altitude. J Wilderness Med 1990; 1:86-92.
4. Hackett PH, Rennie D. The incidence, importance and prophylaxis of acute mountain sickness. Lancet 1976; 2:1149-1155.
5. Basnyat B, Lemaster J, Litch JA. Everest or bust: a cross sectional, epidemiological study of acute mountain sickness at 4243 meters in the Himalayas. Aviat Space Environ Med 1999; 70:867-873.
6. Cumbo TA, Basnyat IJ, Graham J, et al. Acute mountain sickness, dehydration, and bicarbonate clearance: preliminary field data from the Nepal Himalaya. Aviat Space Environ Med 2002; 73:898-901.
7. Bartsch P, Swenson ER, Paul A, et al. Hypoxic ventilatory response, ventilation, gas exchange, and fluid balance in acute mountain sickness. High Alt Med Biol 2002; 3:361-376.
8. Westerterp KR, Robach P, Wouters L, Richalet JP. Water balance and acute mountain sickness before and after arrival at high altitude of 4,350 m. J Appl Physiol 1996; 80:1968-1972.
9. Basnyat B. Acute mountain sickness in local pilgrims to a high altitude lake (4154 m) in Nepal. J Wilderness Med 1993; 4:286-292.
10. Basnyat B, Subedi D, Sleggs J, et al. Disoriented and ataxic pilgrims: an epidemiological study of acute mountain sickness and high-altitude cerebral edema at a sacred lake at 4300 m in the Nepal Himalayas. Wild Environ Med 2000; 11:89-93.
11. Siggaard-Andersen O. An acid-base chart for arterial blood with normal and pathophysiological reference areas. Scand J Clin Lab Invest 1971; 27:239-245.
12. Hackett PH, Oelz U. The Lake Louise consensus on the definition and quantification of altitude illness. In: Sutton JR, Coates G, Houston CS, eds. Hypoxia and mountain medicine. Burlington, VT: Queen City Printers, 1992:327-330.
13. Gonzalez NC, Albrecht T, Sullivan LP, Clancy RL. Compensation of respiratory alkalosis induced after acclimation to simulated altitude. J Appl Physiol 1990; 69:1380-1386.
14. Lahiri S. Physiological responses and adaptations to high altitude. Int Rev Physiol 1977; 15:217-251.
15. Samaja M. Blood gas transport at high altitude. Respiration 1997; 64:422-428.
16. Lahiri S, Rozanov C, Cherniack NS. Altered structure and function of the carotid body at high altitude and associated chemoreflexes. High Alt Med Biol 2000; 1(1):63-74.
17. Singh MV, Salhan AK, Rawal SB, et al. Blood gases, hematology, and renal blood flow during prolonged mountain sojourns at 3500 and 5800m. Aviat Space Environ Med 2003; 74:533-536.
18. Olsen NV Effect of hypoxaemia on water and sodium homeostatic hormones and renal function. Acta Anaesthesiol Scand 1995; 107 (Suppl):165-170.
19. Dubose TD Jr. Acidosis and alkalosis. In: Braunwald E, Fauci AS, Kasper DL, et al, eds. Harrison's principles of internal medicine. 15th Ed. New York, NY: McGraw-Hill Companies, Inc., 2001. p 283-291.
20. Wagner PD, Araoz M, Boushel R, et al. Pulmonary gas exchange and acid-base state at 5,260m in high-altitude Bolivians and acclimatized lowlanders. J Appl Physiol 2002; 92:1393-1400.
21. Moore LG, Niermeyer S, Zamudio S. Human adaption to high altitude: regional and life-cycle perspectives. Am J Phys Anthropol 1998; (Suppl 27):25-64.
22. Abbott Laboratories. Barometric pressure in the I-stat system [monograph]. Chicago, IL: Abbott Laboratories, 2000.
23. Basnyat B, Gertsch JH, Johnson EW, et al. Efficacy of low-dose acetazolamide (125 mg BID) for the prophylaxis of acute mountain sickness: a prospective, double-blind, randomized, placebo-controlled trial. High Alt Med Biol 2003; 4(1):45-52.
24. Basnyat B, Murdoch D. High altitude illness. Lancet 2003; 361:1967-1974.
25. Basnyat B, Cumbo TA, Edelman R. Acute medical problems in the Himalayas outside the setting of altitude illness. High Alt Med Biol 2000; 1:167-174.