Polypharmacy and excessive dosing: Psychiatrists' perceptions of antipsychotic drug prescription

British Journal of Psychiatry

Volumn 187, Issue SEPT., 2005, Pages 243-247

  Ito, Hiroto ^a,d   Koyama, Asuka ^b   Higuchi, Teruhiko ^c  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c NATIONAL INSTITUTE OF MENTAL HEALTH   (Japan)

^d National Center of Neurology and Psychiatry   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ATYPICAL ANTIPSYCHOTIC AGENT; NEUROLEPTIC AGENT;

ADULT; ARTICLE; DISEASE DURATION; FEMALE; HUMAN; JAPAN; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; NURSE; POLYPHARMACY; PRACTICE GUIDELINE; PRESCRIPTION; PSYCHIATRIC DEPARTMENT; PSYCHIATRIST; RISK BENEFIT ANALYSIS; SCHIZOPHRENIA;

ADULT; ALGORITHMS; ANTIPSYCHOTIC AGENTS; ATTITUDE OF HEALTH PERSONNEL; FEMALE; GUIDELINE ADHERENCE; HOSPITALIZATION; HUMANS; JAPAN; MALE; MEDICAL STAFF, HOSPITAL; MIDDLE AGED; NURSING STAFF, HOSPITAL; PHYSICIAN'S PRACTICE PATTERNS; POLYPHARMACY; PRACTICE GUIDELINES; SCHIZOPHRENIA;

EID: 24944518893     PISSN: 00071250     EISSN: None     Source Type: Journal    
DOI: 10.1192/bjp.187.3.243     Document Type: Article

References (36)

1. American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders (4th edn) (DSM-IV). Washington, DC: APA.
2. American Psychiatric Association (1997) Practice guidelines for the treatment of patients with schizophrenia. American Journal of Psychiatry, 154 (suppl.), 1-63.
3. Avorn, J., Soumerai, S. B., Everitt, D. E., et al. (1992) A randomized trial of a program to reduce the use of psychoactive drugs in nursing homes. New England Journal of Medicine, 327, 168-173.
4. Benson, P. R. (1983) Factors associated with antipsychotic drug prescribing by southern psychiatrists. Medical Care, 21, 639-654.
5. Bezchlibnyk-Butler, K. Z. & Jeffries, J. J. (1998) Clinical Handbook of Psychotropic Drugs (8th edn). Seattle, WA: Hogrefe & Huber.
6. Bitter, I., Chou, J. C., Ungvari, G. S., et al. (2003) Prescribing for inpatients with schizophrenia: an international multi-center comparative study. Pharmacopsychiatry, 36, 143-149.
7. Centorrino, F., Goren, J. L., Hennen, J., et al. (2004) Multiple versus single antipsychotic agents for hospitalized psychiatric patients: case-control study of risks versus benefits. American Journal of Psychiatry, 161, 700-706.
8. Chong, M. Y., Tan, C. H., Fujii, S., et al. (2004) Antipsychotic drug prescription for schizophrenia in East Asia: rationale for change. Psychiatry and Clinical Neurosciences, 58, 61-67.
9. Covell, N. H., Jackson, C. T., Evans, A. C., et al. (2002) Antipsychotic prescribing practice in Connecticut's pubic mental health system: rates of changing medications and prescribing styles. Schizophrenia Bulletin, 28, 17-29.
10. Davis, D. A., Thomson, M. A., Oxman, A. D., et al. (1995) Changing physician performance: a systematic review of the effect of continuing medical education strategies. JAMA, 274, 700-705.
11. Diaz, F. J. & de Leon, J. (2002) Excessive antipsychotic dosing in two US state hospitals. Journal of Clinical Psychiatry 63, 998-1003.
12. Freudenreich, O. & Goff, D. C. (2002) Antipsychotic combination therapy in schizophrenia: a review of efficacy and risks of current combinations. Acta Psychiatrica Scandinavica, 106, 323-330.
13. Grimshaw, J. M. & Russell, I. T. (1993) Effect of clinical guidelines on medical practice: a systematic review of rigorous evaluations. Lancet, 342, 1317-1322.
14. Harrington, M., Lelliott, P., Paton, C., et al. (2002) The results of a multi-centre audit of the prescribing of antipsychotic drugs for in-patients in the UK. Psychiatric Bulletin, 26, 414-418.
15. Inagaki, A., Inada, T., Fujii, Y., et al. (1999) Equivalent Dose of Psychotropics (in Japanese). Tokyo: Seiwa Shoten.
16. Kingsbury, S. J., Yi, D. & Simpson, G. M. (2001) Rational and irrational polypharmacy. Psychiatric Services, 52, 1033-1036.
17. Lehman, A. F. & Steinwachs, D. M. (1998) Translating research into practice: the Schizophrenia Patients Outcomes Research Team (PORT) treatment recommendations. Schizophrenia Bulletin, 24, 1-10.
18. Lelliott, P., Paton, C., Harrington, M., et al. (2002) The influence of patient variables on polypharmacy and combined high dose of antipsychotic drugs prescribed for in-patients. Psychiatric Bulletin, 26, 411-414.
19. McCue, R. E., Waheed, R. & Urcuyo, L. (2003) Polypharmacy in patients with schizophrenia. Journal of Clinical Psychiatry, 64, 984-989.
20. National Institute for Clinical Excellence (2002) Guidance on the Use of Newer (Atypical) Antipsychotic Drugs for The treatment of Schizophrenia. Technology Appraisal Guidance No. 43. London: NICE.
21. Patel, M. X., Nikolaou, V. & David, A. S. (2003) Psychiatrists' attitudes to maintenance medication for patients with schizophrenia. Psychological Medicine, 33, 83-89.
22. Procyshyn, R. M., Kennedy, N. B., Tse, G., et al. (2001) Antipsychotic polypharmacy: a survey of discharge prescriptions from a tertiary care psychiatry institution. Canadian Journal of Psychiatry, 46, 334-339.
23. Ray, W. A., Meredith, S., Thapa, P. B., et al. (2001) Antipsychotics and the risk of sudden cardiac death. Archives of General Psychiatry, 58, 1161-1167.
24. c-interval abnormalities and psychotropic drug therapy in psychiatric patients. Lancet, 355, 1048-1052.
25. Remington, G., Shammi, C. M., Sethna, R., et al. (2001) Antipsychotic dosing patterns for schizophrenia in three treatment settings. Psychiatric Services, 52, 96-98.
26. Royal College of Psychiatrists (1993) Consensus Statement on the Use of High Dose Antipsychotic Medication. Council Report CR26. London: Royal College of Psychiatrists.
27. Shiloh, R., Zemishlany, Z., Aizenberg, D., et al. (1997) Sulpiride augmentation in people with schizophrenia partially responsive to clozapine. A double-blind, placebo-controlled study. British Journal of Psychiatry, 171, 569-573.
28. Sohler, N. L., Walkup, J., McAlpine, D., et al. (2003) Antipsychotic dosage at hospital discharge and outcomes among persons with schizophrenia. Psychiatric Services, 54, 1258-1263.
29. Taylor, D. (2002) Antipsychotic prescribing - time to review practice. Psychiatric Bulletin, 26, 401-402.
30. Taylor, D., Mace, S., Mir, S., et al. (2000) A prescription survey of the use of atypical antipsychotics for hospital inpatients in the United Kingdom. International Journal of Psychiatry in Clinical Practice, 4, 41-46.
31. Taylor, D., McConnell, D., McConnell, H., et al. (2001) The Maudsley 2001 Prescribing Guidelines (6th edn). London: Taylor & Francis.
32. Taylor, D., Mir, S., Mace, S., et al. (2002) Co-prescribing of atypical and typical antipsychotics - prescribing sequence and documented outcome. Psychiatric Bulletin, 26, 170-172.
33. Thompson, C. (1994) The use of high-dose antipsychotic medication. British Journal of Psychiatry, 164, 448-458.
34. Ungvari, G. S., Pang, A. H. T., Chiu, H. F. K., et al. (1996) Psychotropic drug prescription in rehabilitation: a survey in Hong Kong. Social Psychiatry and Psychiatric Epidemiology, 31, 288-291.
35. Ungvari, G. S., Chow, L. Y., Chiu, H. F., et al. (1997) Modifying psychotropic drug prescription patterns: a follow-up survey. Psychiatry and Clinical Neurosciences, 51, 309-314.
36. Waddington, J. L., Youssef, H. A. & Kinsella, A. (1998) Mortality in schizophrenia. Antipsychotic polypharmacy and absence of adjunctive anticholinergics over the course of a 10-year prospective study. British Journal of Psychiatry, 173, 325-329.