Microvascular density, vascular endothelial growth factor A, and its receptors in endometrial blood vessels in patients with menorrhagia

Fertility and Sterility

Volumn 84, Issue 3, 2005, Pages 692-700

  Mints, Miriam ^a   Blomgren, Bo ^c,d   Falconer, Christian ^b   Fianu Jonasson, Aino ^a   Palmblad, Jan ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b DANDERYD HOSPITAL   (Sweden)

^c ASTRAZENECA R AND D   (Sweden)

^d UPPSALA UNIVERSITY   (Sweden)

Author keywords

Angiogenesis; Endometrium; Menorrhagia; Receptors; VEGF

Indexed keywords

CD34 ANTIGEN; HORMONE; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

ADULT; ARTERIOLE; ARTICLE; BLOOD SAMPLING; BLOOD VESSEL PERMEABILITY; CAPILLARY; CLINICAL ARTICLE; CLINICAL OBSERVATION; COMPUTER ANALYSIS; CONTROLLED STUDY; ENDOMETRIUM; ENDOMETRIUM BIOPSY; ENDOTHELIUM; FEMALE; FEMALE FERTILITY; HORMONE DETERMINATION; HUMAN; HYSTEROSCOPY; IDIOPATHIC DISEASE; IMAGE ANALYSIS; IMMUNOASSAY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MENORRHAGIA; MICROVASCULATURE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; SAMPLE; STAINING; STEREOLOGY; STEREOMETRY; UNIVERSITY HOSPITAL; UPREGULATION; UTERINE BLOOD VESSEL;

ADULT; ARTERIOLES; CAPILLARIES; CAPILLARY PERMEABILITY; ENDOMETRIUM; FEMALE; HUMANS; MENORRHAGIA; MICROCIRCULATION; MIDDLE AGED; PROSPECTIVE STUDIES; STATISTICS, NONPARAMETRIC; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 24944494882     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2005.03.065     Document Type: Article

References (41)

1. L. Hallberg, A.M. Hogdahl, L. Nilsson, G. Rybo Menstrual blood loss - a population study. Variation at different ages and attempts to define normality Acta Obstet Gynecol Scand 45 1966 320 351
2. D. Gath, M. Osborn, G. Bungay, S. Iles, A. Day, A. Bond Psychiatric disorder and gynaecological symptoms in middle aged women a community survey BMJ (Clin Res Ed) 294 1987 213 218
3. P. Carmeliet, R.K. Jain Angiogenesis in cancer and other diseases Nature 407 2000 249 257
4. S.K. Smith Angiogenesis and reproduction BJOG 108 2001 777 783
5. M. Hickey, D. Dwarte, I.S. Fraser Superficial endometrial vascular fragility in Norplant users and in women with ovulatory dysfunctional uterine bleeding Hum Reprod 15 2000 1509 1514
6. N. Ferrara Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis therapeutic implications Semin Oncol 29 2002 10 14
7. N. Ferrara, H.P. Gerber The role of vascular endothelial growth factor in angiogenesis Acta Haematol 106 2001 148 156
8. T. Matsumoto, L. Claesson-Welsh VEGF receptor signal transduction Sci STKE 2001 2001 RE21
9. H.F. Dvorak Vascular permeability factor/vascular endothelial growth factor a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy J Clin Oncol 20 2002 4368 4380
10. G. Meduri, P. Bausero, M. Perrot-Applanat Expression of vascular endothelial growth factor receptors in the human endometrium modulation during the menstrual cycle Biol Reprod 62 2000 439 447
11. L. Zhang, P.A. Scott, H. Turley, R. Leek, C.E. Lewis, K.C. Gatter Validation of anti-vascular endothelial growth factor (anti-VEGF) antibodies for immunohistochemical localization of VEGF in tissue sections expression of VEGF in the human endometrium J Pathol 185 1998 402 408
12. T.M. Lau, B. Affandi, P.A. Rogers The effects of levonorgestrel implants on vascular endothelial growth factor expression in the endometrium Mol Hum Reprod 5 1999 57 63
13. L.G. Lundberg, R. Lerner, P. Sundelin, R. Rogers, J. Folkman, J. Palmblad Bone marrow in polycythemia vera, chronic myelocytic leukemia, and myelofibrosis has an increased vascularity Am J Pathol 157 2000 15 19
14. T. Padro, S. Ruiz, R. Bieker, H. Burger, M. Steins, J. Kienast Increased angiogenesis in the bone marrow of patients with acute myeloid leukemia Blood 95 2000 2637 2644
15. M. Schindl, P. Birner, A. Obermair, L. Kiesel, R. Wenzl Increased microvessel density in adenomyosis uteri Fertil Steril 75 2001 131 135
16. H.J. Gundersen, T.F. Bendtsen, L. Korbo, N. Marcussen, A. Moller, K. Nielsen Some new, simple and efficient stereological methods and their use in pathological research and diagnosis APMIS 96 1988 379 394
17. E.R. Weibel Stereological methods, Vol. 1. Practical methods for biological morphometry 1979 Academic Press London
18. J.J. Michnovicz, R.J. Hershcopf, H. Naganuma, H.L. Bradlow, J. Fishman Increased 2-hydroxylation of estradiol as a possible mechanism for the anti-estrogenic effect of cigarette smoking N Engl J Med 315 1986 1305 1309
19. D.S. Charnock-Jones, A.M. Sharkey, J. Rajput-Williams, D. Burch, J.P. Schofield, S.A. Fountain Identification and localization of alternately spliced mRNAs for vascular endothelial growth factor in human uterus and estrogen regulation in endometrial carcinoma cell lines Biol Reprod 48 1993 1120 1128
20. M. Ancelin, H. Buteau-Lozano, G. Meduri, M. Osborne-Pellegrin, S. Sordello, J. Plouet A dynamic shift of VEGF isoforms with a transient and selective progesterone-induced expression of VEGF189 regulates angiogenesis and vascular permeability in human uterus Proc Natl Acad Sci USA 99 2002 6023 6028
21. M.C. Rees, M.S. Dunnill, A.B. Anderson, A.C. Turnbull Quantitative uterine histology during the menstrual cycle in relation to measured menstrual blood loss Br J Obstet Gynaecol 91 1984 662 666
22. P.A. Rogers, C.L. Au, B. Affandi Endometrial microvascular density during the normal menstrual cycle and following exposure to long-term levonorgestrel Hum Reprod 8 1993 1396 1404
23. J.W. Maas, P.G. Groothuis, G.A. Dunselman, A.F. de Goeij, H.A. Struyker Boudier, J.L. Evers Endometrial angiogenesis throughout the human menstrual cycle Hum Reprod 16 2001 1557 1561
24. M. Mints, B. Blomgren, C. Falconer, J. Palmblad Expression of the vascular endothelial growth factor (VEGF) family in human endometrial blood vessels Scand J Clin Lab Invest 62 2002 167 175
25. B. Moller, B. Lindblom, M. Olovsson Expression of the vascular endothelial growth factors B and C and their receptors in human endometrium during the menstrual cycle Acta Obstet Gynecol Scand 81 2002 817 824
26. C.E. Gargett, F.L. Lederman, T.M. Lau, N.H. Taylor, P.A. Rogers Lack of correlation between vascular endothelial growth factor production and endothelial cell proliferation in the human endometrium Hum Reprod 14 1999 2080 2088
27. J. Kooy, N.H. Taylor, D.L. Healy, P.A. Rogers Endothelial cell proliferation in the endometrium of women with menorrhagia and in women following endometrial ablation Hum Reprod 11 1996 1067 1072
28. K.M. Abberton, N.H. Taylor, D.L. Healy, P.A. Rogers Vascular smooth muscle alpha-actin distribution around endometrial arterioles during the menstrual cycle increased expression during the perimenopause and lack of correlation with menorrhagia Hum Reprod 11 1996 204 211
29. M. Saito, M. Hamasaki, M. Shibuya Induction of tube formation by angiopoietin-1 in endothelial cell/fibroblast co-culture is dependent on endogenous VEGF Cancer Sci 94 2003 782 790
30. J.M. Krum, A. Khaibullina Inhibition of endogenous VEGF impedes revascularization and astroglial proliferation roles for VEGF in brain repair Exp Neurol 181 2003 241 257
31. C.H. Chung, W.B. Wu, T.F. Huang Aggretin, a snake venom-derived endothelial integrin alpha 2 beta 1 agonist, induces angiogenesis via expression of vascular endothelial growth factor Blood 103 2004 2105 2113
32. P. Carmeliet, L. Moons, A. Luttun, V. Vincenti, V. Compernolle, M. De Mol Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions Nat Med 7 2001 575 583
33. S. Hiratsuka, Y. Maru, A. Okada, M. Seiki, T. Noda, M. Shibuya Involvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesis Cancer Res 61 2001 1207 1213
34. V. Dayanir, R.D. Meyer, K. Lashkari, N. Rahimi Identification of tyrosine residues in vascular endothelial growth factor receptor-2/FLK-1 involved in activation of phosphatidylinositol 3-kinase and cell proliferation J Biol Chem 276 2001 17686 17692
35. J. Waltenberger, L. Claesson-Welsh, A. Siegbahn, M. Shibuya, C.H. Heldin Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor J Biol Chem 269 1994 26988 26995
36. H. Gille, J. Kowalski, B. Li, J. LeCouter, B. Moffat, T.F. Zioncheck Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific vascular endothelial growth factor mutants J Biol Chem 276 2001 3222 3230
37. S. Shiose, T. Sakamoto, H. Yoshikawa, Y. Hata, Y. Kawano, T. Ishibashi Gene transfer of a soluble receptor of VEGF inhibits the growth of experimental eyelid malignant melanoma Invest Ophthalmol Vis Sci 41 2000 2395 2403
38. J. Miotla, R. Maciewicz, J. Kendrew, M. Feldmann, E. Paleolog Treatment with soluble VEGF receptor reduces disease severity in murine collagen-induced arthritis Lab Invest 80 2000 1195 1205
39. H. Chen, U. Ikeda, M. Shimpo, Y. Maeda, M. Shibuya, K. Ozawa Inhibition of vascular endothelial growth factor activity by transfection with the soluble FLT-1 gene J Cardiovasc Pharmacol 36 2000 498 502
40. J.S. Krussel, E.M. Casan, F. Raga, J. Hirchenhain, Y. Wen, H.Y. Huang Expression of mRNA for vascular endothelial growth factor transmembraneous receptors Flt1 and KDR, and the soluble receptor sflt in cycling human endometrium Mol Hum Reprod 5 1999 452 458
41. A. Luttun, P. Carmeliet Soluble VEGF receptor Flt1 the elusive preeclampsia factor discovered? J Clin Invest 111 2003 600 602