Pesticide metabolism and potential for metabolic interactions

Journal of Biochemical and Molecular Toxicology

Volumn 19, Issue 4, 2005, Pages 276-277

  Rose, Randy L ^a   Hodgson, Ernest ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYCARBOFURAN; ALDEHYDE DEHYDROGENASE; BENZOIC ACID DERIVATIVE; BENZYL ALCOHOL DERIVATIVE; CARBAMATE INSECTICIDE; CARBARIL; CARBOFURAN; CHLORPYRIFOS; CHLORPYRIFOSOXON; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; CYTOCHROME P450 ISOENZYME; ESTERASE; FONOFOS; HEME; ORGANOPHOSPHATE INSECTICIDE; PERMETHRIN; PESTICIDE; PHENOXYBENZOIC ACID; PHENOXYLBENZYL ALCOHOL; PHORATE; SULFUR; UNCLASSIFIED DRUG;

AGRICULTURAL WORKER; BIODEGRADATION; CONFERENCE PAPER; DETOXIFICATION; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME MECHANISM; ENZYME SUBSTRATE; HUMAN; LIVER CELL; LIVER MICROSOME; METABOLISM; METABOLITE; MOLECULAR INTERACTION; NONHUMAN; PROTEIN EXPRESSION; SULFOXIDATION;

AGRICULTURE; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; MICROSOMES, LIVER; OCCUPATIONAL EXPOSURE; PESTICIDES;

EID: 24944489229     PISSN: 10956670     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbt.20077     Document Type: Conference Paper

References (8)

1. Tang J, Rose RL, Brimfield AA, Dai D, Goldstein JA, Hodgson E. Metabolism of chlorpyrifos by human cytochrome P450 isoforms and human, mouse and rat liver microsomes. Drug Metabol Dispos 2001;29:1201-1204.
2. Usmani KA, Karoly ED, Hodgson E, Rose RL. In vitro sulfoxidation of thioether compounds by human cytochrome P450 and flavin-containing monooxygenase isoforms with particular reference to the CYP2C subfamily. Drug Metab Dispos 2004;32:333-339.
3. Tang J, Cao Y, Rose RL, Hodgson E. In vitro metabolism of carbaryl by human cytochrome P450 and its inhibition by chlorpyrifos. Chem Biol Interact 2002;141:229-241.
4. Usmani KA, Hodgson E, Rose RL. In vitro metabolism of carbofuran by human, mouse, and rat cytochrome P450 and interactions with chlorpyrifos, testosterone, and estradiol. Chem Biol Interact 2004;150:221-232.
5. Choi J, Rose RL, Hodgson, E. In vitro human metabolism of permethrin: The role of human alcohol and aldehyde dehydrogenases. Pestic Biochem Physiol 2002;73: 117-128.
6. Choi J, Hodgson E, Rose RL. Inhibition of transpermethrin hydrolysis in human liver fractions by chlorpyrifos oxon and carbaryl. Drug Metab Drug Interact 2004;20:233-246.
7. Usmani KA, Rose RL, Hodgson E. Inhibition and activation of the human liver and human cytochrome P450 3A4 metabolism of testosterone by deployment-related chemicals. Drug Metabol Dispos 2003;31:384-391.
8. Rose RL, Tang J, Choi J, Cao Y, Usmani A, Cherrington N, Hodgson E. Pesticide metabolism in humans, including polymorphisms. Second J Work Environ. Health 2005;31 suppl 1:156-163.