Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin

Clinical and Diagnostic Laboratory Immunology

Volumn 12, Issue 9, 2005, Pages 1135-1138

  Zanetti, Stefania ^a   Bua, Alessandra ^a   Delogu, Giovanni ^a,d   Pusceddu, Cinzia ^a,d   Mura, Maristella ^a   Saba, Franca ^a   Pirina, Piero ^a   Garzelli, Carlo ^b   Vertuccio, Cono ^c   Sechi, Leonardo A ^a   Fadda, Giovanni ^d  

^a UNIVERSITY OF SASSARI   (Italy)

^b UNIVERSITY OF PISA   (Italy)

^c Azienda Sanitaria Locale No 3 of Nuoro   (Italy)

^d CATHOLIC UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; HEMAGGLUTININ; HEPARIN BINDING HEMAGGLUTININ; PROTEIN PE PGRS; PROTEIN PPE; RECOMBINANT ANTIGEN; UNCLASSIFIED DRUG;

ANTIBODY SPECIFICITY; ANTIGEN DETECTION; ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMORAL IMMUNITY; IMMUNOREACTIVITY; LUNG TUBERCULOSIS; MAJOR CLINICAL STUDY; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL; PROTEIN METHYLATION; PROTEIN PURIFICATION; SERODIAGNOSIS;

ANTIBODIES, BACTERIAL; ANTIBODY FORMATION; ANTIBODY SPECIFICITY; ANTIGENS, BACTERIAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEMAGGLUTININS; HUMANS; LECTINS; METHYLATION; MYCOBACTERIUM TUBERCULOSIS; RECOMBINANT PROTEINS; TUBERCULOSIS, PULMONARY;

EID: 24944475556     PISSN: 1071412X     EISSN: None     Source Type: Journal    
DOI: 10.1128/CDLI.12.9.1135-1138.2005     Document Type: Article

References (16)

1. Ardito, F., B. Posteraro, M. Sanguinetti, S. Zanetti, and G. Fadda. 2001. Evaluation of BACTEC Mycobacteria Growth Indicator Tube (MGIT 960) automated system for drug susceptibility testing of Mycobacterium tuberculosis. J. Clin. Microbiol. 39:4440-4444.
2. Brennan, M. J., and G. Delogu. 2002. The PE multigene family: a 'molecular mantra' for mycobacteria. Trends Microbiol. 10:246-249.
3. Catanzaro, A., S. Perry, J. E. Clarridge, S. Dunbar, S. Goodnight-While, P. LoBue, P. Christopher, G. E. Pfyffer, M. F. Sierra, R. Weber, G. Woods, G. Mathews, V. Jonas, K. Smith, and P. Della-Latta. 2000. The role of clinical suspicion in evaluating a new diagnostic test for active tuberculosis: results of a multicenter prospective trial. JAMA 283:639-645.
4. Cole, S. T., R. Brosch, J. Parkhill, T. Garnier, C. Churcher, D. Harris, S. V. Gordon, K. Eiglmeier, S. Gas, C. E. Barry III, F. Tekaia, K. Badcock, D. Basham, D. Brown, T. Chillingworth, R. Connor, R. Davies, K. Devlin, T. Feltwell, S. Gentles, N. Hamlin, S. Holroyd, T. Hornsby, K. Jagels, and B. G. Barrell. 1998. Deciphering the biology of M. tuberculosis from the complete genome sequence. Nature 393:537-544.
5. Delogu, G., A. Bua, C. Pusceddu, M. Parra, G. Fadda, M. J. Brennan, and S. Zanetti. 2004. Expression and purification of recombinant methylated HBHA in M. smegmatis. FEMS Microbiol. Lett. 239:33-39.
6. Delogu, G., and M. J. Brennan. 1999. Functional domains present in the mycobacterial hemagglutinin, HBHA. J. Bacteriol. 181:7464-7469.
7. Delogu, G., and M. J. Brennan. 2001. Comparative immune response to PE and PE_PGRS antigens of Mycobacterium tuberculosis. Infect. Immun. 69:5606-5611.
8. Demangel, C., P. Brodin, P. J. Cockle, R. Brosch, L. Majlessi, C. Leclerc, and S. T. Cole. 2004. Cell envelope protein PPE68 contributes to Mycobacterium tuberculosis RD1 immunogenicity independently of a 10-kilodalton culture filtrate protein and ESAT-6. Infect. Immun. 72:2170-2176.
9. Lilenbaum, W., M. C. Pessolani, and L. S. Fonseca. 2001. The use of Ag85 complex as antigen in ELISA for the diagnosis of bovine tuberculosis in dairy cows in Brazil. J. Vet. Med. B 48:161-166.
10. Masungi, C., S. Temmerman, J. P. Van Vooren, A. Drowart, K. Pethe, F. D. Menozzi, C. Locht, and F. Mascart. 2002. Differential T and B cell responses against M. tuberculosis heparin-binding hemagglutinin adhesin in infected healthy individuals and patients with tuberculosis. J. Infect. Dis. 185:513-520.
11. Pai, M., L. W. Riley, and J. M. Colford, Jr. 2004. Interferon-gamma assays in the immunodiagnosis of tuberculosis: a systematic review. Lancet Infect. Dis. 4:761-766.
12. Pethe, K., S. Alonso, F. Biet, G. Delogu, M. J. Brennan, C. Locht, and F. D. Menozzi. 2001. The heparin-binding haemagglutinin of M. tuberculosis is required for extrapulmonary dissemination. Nature 412:190-194.
13. Pethe, K., P. Bifani, H. Drobecq, C. Sergheraert, A. S. Debrie, C. Locht, and F. D. Menozzi. 2002. Mycobacterial heparin-binding hemagglutinin and laminin-binding protein share antigenic methyllysines that confer resistance to proteolysis. Proc. Natl. Acad. Sci. USA 99:10759-10764.
14. Singh, K. K., X. Zhang, A. S. Patibandla, P. Chien, Jr., and S. Laal. 2001. Antigens of Mycobacterium tuberculosis expressed during preclinical tuberculosis: serological immunodominance of proteins with repetitive amino acid sequences. Infect. Immun. 69:4185-4191.
15. Temmerman, S., K. Pethe, M. Parra, S. Alonso, C. Rouanet, T. Pickett, A. Drowart, A. S. Debrie, G. Delogu, F. D. Menozzi, C. Sergheraert, M. J. Brennan, F. Mascart, and C. Locht. 2004. Methylation-dependent T cell immunity to M. tuberculosis heparin-binding hemagglutinin. Nat. Med. 10:935-941.
16. World Health Organization. 1999. Global tuberculosis control. Report W.H.O/TB/99.259. World Health Organization, Geneva, Switzerland.