CYP1A1 is a major enzyme responsible for the metabolism of granisetron in human liver microsomes

Current Drug Metabolism

Volumn 6, Issue 5, 2005, Pages 469-480

  Nakamura, Hirokun ^a   Ariyoshi, N ^a   Okada, K ^a   Nakasa, H ^a   Nakazawa, K ^a   Kitada, M ^a  

^a CHIBA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

CYP1A1; CYP3A4; Granisetron; Human liver microsomes; Metabolism

Indexed keywords

7 HYDROXYGRANISETRON; 9' NORGRANISETRON; CYTOCHROME P450 1A1; CYTOCHROME P450 3A4; CYTOCHROME P450 ISOENZYME; DRUG METABOLITE; DRUG METABOLIZING ENZYME; ENZYME ANTIBODY; GRANISETRON; OXYGENASE; SEROTONIN 3 ANTAGONIST; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ADOLESCENT; ADULT; AGED; DEMETHYLATION; DRUG HYDROXYLATION; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME MECHANISM; FEMALE; HUMAN; HUMAN CELL; LIVER MICROSOME; LIVER MICROSOME METABOLISM; MALE; PROTEIN EXPRESSION; REVIEW;

ADOLESCENT; ADULT; AGED; ANIMALS; ANTIBODIES, BLOCKING; BENZOPYRENE HYDROXYLASE; CYTOCHROME P-450 CYP1A1; FEMALE; GRANISETRON; HUMANS; HYDROXYLATION; INSECTS; ISOENZYMES; KINETICS; MALE; MICROSOMES, LIVER; MIDDLE AGED; TESTOSTERONE 5-ALPHA-REDUCTASE;

EID: 24944465760     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920005774330666     Document Type: Review

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