메뉴 건너뛰기




Volumn 7, Issue 5, 2005, Pages 333-338

Advances in the treatment of chronic lymphocytic leukemia

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ALEMTUZUMAB; ANTIINFECTIVE AGENT; ANTIVIRUS AGENT; CASPASE 3; CD19 ANTIGEN; CD20 ANTIBODY; CD20 ANTIGEN; CD23 ANTIGEN; CD40 LIGAND; CD52 ANTIGEN; CHLORAMBUCIL; CLADRIBINE; CORTICOSTEROID; CYCLIN DEPENDENT KINASE; CYCLOPHOSPHAMIDE; CYTOTOXIC AGENT; FLAVOPIRIDOL; FLUDARABINE; GAMMA INTERFERON; INTERLEUKIN 12; LUMILIXIMAB; MONOCLONAL ANTIBODY; OBLIMERSEN; PENTOSTATIN; PHOSPHOTRANSFERASE; PREDNISONE; PROTEIN BCL 2; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; RITUXIMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 24944445228     PISSN: 15233790     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11912-005-0059-0     Document Type: Review
Times cited : (4)

References (50)
  • 1
    • 0026038974 scopus 로고
    • B-cell chronic lymphocytic leukemia: Present status and future directions
    • and The French Cooperative Group on CLL
    • Dighiero G, Travade P, Chevret S, et al., and The French Cooperative Group on CLL: B-cell chronic lymphocytic leukemia: present status and future directions. Blood 1991, 78:1901-1914.
    • (1991) Blood , vol.78 , pp. 1901-1914
    • Dighiero, G.1    Travade, P.2    Chevret, S.3
  • 2
    • 0028931830 scopus 로고
    • Review article: Advances in the biology and treatment of B-cell chronic lymphocytic leukemia
    • O'Brien S, del Giglio A, Keating M: Review article: Advances in the biology and treatment of B-cell chronic lymphocytic leukemia. Blood 1995, 85:307-318.
    • (1995) Blood , vol.85 , pp. 307-318
    • O'Brien, S.1    del Giglio, A.2    Keating, M.3
  • 3
    • 0024216099 scopus 로고
    • Fludarabine monophosphate: A potentially useful agent in chronic lymphocytic leukemia
    • Grever MR, Kopecky KJ, Coltman CA, et al.: Fludarabine monophosphate: a potentially useful agent in chronic lymphocytic leukemia. Nouvelle Revue Francaise D'Hemtologie 1988, 320:457-459.
    • (1988) Nouvelle Revue Francaise D'Hemtologie , vol.320 , pp. 457-459
    • Grever, M.R.1    Kopecky, K.J.2    Coltman, C.A.3
  • 4
    • 0024319910 scopus 로고
    • Fludarabine: A new agent with major activity against chronic lymphocytic leukemia
    • Keating MJ, Kantarjian H, Talpaz et al.: Fludarabine: a new agent with major activity against chronic lymphocytic leukemia. Blood 1989, 74:19-25.
    • (1989) Blood , vol.74 , pp. 19-25
    • Keating, M.J.1    Kantarjian, H.2    Talpaz3
  • 5
    • 0027465143 scopus 로고
    • High complete remission rate from 2-chloro-2′ deoxyadenosine in previously treated patients with B-cell chronic lymphocytic leukemia: Response predicted by rapid decrease of blood lymphocyte count
    • Juliusson G, Liliemark J: High complete remission rate from 2-chloro-2′ deoxyadenosine in previously treated patients with B-cell chronic lymphocytic leukemia: response predicted by rapid decrease of blood lymphocyte count. J Clin Oncol 1993, 11:679-689.
    • (1993) J. Clin. Oncol. , vol.11 , pp. 679-689
    • Juliusson, G.1    Liliemark, J.2
  • 6
    • 0028945716 scopus 로고
    • 2-chlorodeoxyadenosine activity in patients with untreated chronic lymphocytic leukemia
    • Saven A, Leman RH, Kosty M, et al.: 2-chlorodeoxyadenosine activity in patients with untreated chronic lymphocytic leukemia. J Clin Oncol 1995, 13:570-574.
    • (1995) J. Clin. Oncol. , vol.13 , pp. 570-574
    • Saven, A.1    Leman, R.H.2    Kosty, M.3
  • 7
    • 0021933387 scopus 로고
    • Low-dose deoxycoformycin in lymphoid malignancy
    • Grever MR, Leiby JM, Kraut EH, et al.: Low-dose deoxycoformycin in lymphoid malignancy. J Clin Oncol 1985, 3:1196-1201.
    • (1985) J. Clin. Oncol. , vol.3 , pp. 1196-1201
    • Grever, M.R.1    Leiby, J.M.2    Kraut, E.H.3
  • 8
    • 0024551346 scopus 로고
    • Pentostatin in chronic lymphocytic leukemia: A phase II trial of Cancer and Leukemia Group B
    • Dillman RO, Mick R, Ross McIntyre OR: Pentostatin in chronic lymphocytic leukemia: a phase II trial of Cancer and Leukemia Group B. J Clin Oncol 1989, 7:433-438.
    • (1989) J. Clin. Oncol. , vol.7 , pp. 433-438
    • Dillman, R.O.1    Mick, R.2    Ross McIntyre, O.R.3
  • 9
    • 0345337254 scopus 로고    scopus 로고
    • Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: Half of patients respond to a four-dose treatment program
    • McLaughlin P, Grillo-Lopez AJ, Link BK, et al.: Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program. J Clin Oncol 1998, 16:2825-2833.
    • (1998) J. Clin. Oncol. , vol.16 , pp. 2825-2833
    • McLaughlin, P.1    Grillo-Lopez, A.J.2    Link, B.K.3
  • 10
    • 0032931320 scopus 로고    scopus 로고
    • IDEC-C2B8 anti-CD20 (rituximab) immunotherapy in patients with low-grade non-Hodgkin's lymphoma and lymphoproliferative disorders: Evaluation of response on 48 patients
    • Nguyen DT, Amess JA, Doughty H, et al.: IDEC-C2B8 anti-CD20 (rituximab) immunotherapy in patients with low-grade non-Hodgkin's lymphoma and lymphoproliferative disorders: evaluation of response on 48 patients. Eur J Haematol 1999, 62:76-82.
    • (1999) Eur. J. Haematol. , vol.62 , pp. 76-82
    • Nguyen, D.T.1    Amess, J.A.2    Doughty, H.3
  • 11
    • 0030897222 scopus 로고    scopus 로고
    • Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia
    • European Study Group of CAMPATH-1H Treatment in Chronic Lymphocytic Leukemia
    • Osterborg A, Dyer MJ, Bunjes D, et al.: Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia. European Study Group of CAMPATH-1H Treatment in Chronic Lymphocytic Leukemia. J Clin Oncol 1997, 15:1567-1574.
    • (1997) J. Clin. Oncol. , vol.15 , pp. 1567-1574
    • Osterborg, A.1    Dyer, M.J.2    Bunjes, D.3
  • 12
    • 0031790767 scopus 로고    scopus 로고
    • Cross-linking of the CAMPATH-1 antigen (CD52) mediates growth inhibition in human B- and T-lymphoma cell lines, and subsequent emergence of CD52-deficient cells
    • Rowan W, Tite J, Topley P, Brett SJ: Cross-linking of the CAMPATH-1 antigen (CD52) mediates growth inhibition in human B- and T-lymphoma cell lines, and subsequent emergence of CD52-deficient cells. Immunology 1998, 95:427-436.
    • (1998) Immunology , vol.95 , pp. 427-436
    • Rowan, W.1    Tite, J.2    Topley, P.3    Brett, S.J.4
  • 13
    • 0344729013 scopus 로고    scopus 로고
    • Chlorambucin in indolent chronic lymphocytic leukemia
    • Dighiero G, Maloum K, Desablens B, et al.: Chlorambucin in indolent chronic lymphocytic leukemia. N Engl J Med 1998, 338:1506-1514.
    • (1998) N. Engl. J. Med. , vol.338 , pp. 1506-1514
    • Dighiero, G.1    Maloum, K.2    Desablens, B.3
  • 14
    • 0026015638 scopus 로고
    • Fludarabine: A new agent with marked cytoreductive activity in untreated chronic lymphocytic leukemia
    • Keating MJ, Kantarjian H, O'Brien S, et al.: Fludarabine: a new agent with marked cytoreductive activity in untreated chronic lymphocytic leukemia. J Clin Oncol 1991, 9:44-49.
    • (1991) J. Clin. Oncol. , vol.9 , pp. 44-49
    • Keating, M.J.1    Kantarjian, H.2    O'Brien, S.3
  • 15
    • 0034649696 scopus 로고    scopus 로고
    • Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia
    • Rai KR, Peterson BL, Appelbaum FR, et al.: Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia. N Engl J Med 2000, 343:1750-1757.
    • (2000) N. Engl. J. Med. , vol.343 , pp. 1750-1757
    • Rai, K.R.1    Peterson, B.L.2    Appelbaum, F.R.3
  • 16
    • 0026776598 scopus 로고
    • Response assessment in chronic lymphocytic leukemia after fludarabine plus prednisone: Clinical, immunophenotypic, and molecular analysis
    • Robertson LE, Huh YO, Butler JJ, et al.: Response assessment in chronic lymphocytic leukemia after fludarabine plus prednisone: Clinical, immunophenotypic, and molecular analysis. Blood 1992, 80:29-36.
    • (1992) Blood , vol.80 , pp. 29-36
    • Robertson, L.E.1    Huh, Y.O.2    Butler, J.J.3
  • 17
    • 0033828586 scopus 로고    scopus 로고
    • Consolidation therapy with high-dose cyclophosphamide improves the quality of response in patients with chronic lymphocytic leukemia treated with fludarabine as induction therapy
    • Weiss M, Glenn M, Maslak P, et al.: Consolidation therapy with high-dose cyclophosphamide improves the quality of response in patients with chronic lymphocytic leukemia treated with fludarabine as induction therapy. Leukemia 2000, 14:557-582.
    • (2000) Leukemia , vol.14 , pp. 557-582
    • Weiss, M.1    Glenn, M.2    Maslak, P.3
  • 18
    • 0027323550 scopus 로고
    • Results of fludarabine and prednisone therapy in 264 patients with chronic lymphocytic leukemia with multivariate analysis-derived prognostic model for response to treatment
    • O'Brien S, Kantarjian H, Beran M, et al.: Results of fludarabine and prednisone therapy in 264 patients with chronic lymphocytic leukemia with multivariate analysis-derived prognostic model for response to treatment. Blood 1993, 82:1695-1700.
    • (1993) Blood , vol.82 , pp. 1695-1700
    • O'Brien, S.1    Kantarjian, H.2    Beran, M.3
  • 19
    • 0027483579 scopus 로고
    • A phase I trial of combination fludarabine monophosphate and chlorambucil in chronic lymphocytic leukemia: A Southwest Oncology Group study
    • Elias L, Stock-Novack D, Head DR, et al.: A phase I trial of combination fludarabine monophosphate and chlorambucil in chronic lymphocytic leukemia: A Southwest Oncology Group study. Leukemia 1993, 7:361-365.
    • (1993) Leukemia , vol.7 , pp. 361-365
    • Elias, L.1    Stock-Novack, D.2    Head, D.R.3
  • 20
    • 0028022841 scopus 로고
    • Concomitant administration of chlorambucil limits dose intensity of fludarabine in previously treated patients with chronic lymphocytic leukemia
    • Weiss M, Spiess T, Berman E, Kempin S: Concomitant administration of chlorambucil limits dose intensity of fludarabine in previously treated patients with chronic lymphocytic leukemia. Leukemia 1994, 8:1290-1293.
    • (1994) Leukemia , vol.8 , pp. 1290-1293
    • Weiss, M.1    Spiess, T.2    Berman, E.3    Kempin, S.4
  • 21
    • 0035282055 scopus 로고    scopus 로고
    • Results of the fludarabine and cyclophosphamide combination regimen in chronic lymphocytic leukemia
    • O'Brien S, Kantarjian HM, Cortes MC, et al.: Results of the fludarabine and cyclophosphamide combination regimen in chronic lymphocytic leukemia. J Clin Oncol 2001, 19:1414-1420.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 1414-1420
    • O'Brien, S.1    Kantarjian, H.M.2    Cortes, M.C.3
  • 22
    • 23044501404 scopus 로고    scopus 로고
    • Chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab for relapsed and refractory chronic lymphocytic leukemia
    • Wierda W, O'Brien S, Wen S, et al.: Chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab for relapsed and refractory chronic lymphocytic leukemia. J Clin J Clin Oncol 2005, 23:4070-4078.
    • (2005) J. Clin. J. Clin. Oncol. , vol.23 , pp. 4070-4078
    • Wierda, W.1    O'Brien, S.2    Wen, S.3
  • 23
    • 23044510136 scopus 로고    scopus 로고
    • Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia
    • Keating MJ, O'Brien S, Albitar M, et al.: Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia. J Clin Oncol 2005, 23:4079-4088.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 4079-4088
    • Keating, M.J.1    O'Brien, S.2    Albitar, M.3
  • 24
    • 0034235909 scopus 로고    scopus 로고
    • Fludarabine and cyclophosphamide with filgrastim support in patients with previously untreated indolent lymphoid malignancies
    • Flinn IW, Byrd JC, Morrison C, et al.: Fludarabine and cyclophosphamide with filgrastim support in patients with previously untreated indolent lymphoid malignancies. Blood 2000, 96:71-75.
    • (2000) Blood , vol.96 , pp. 71-75
    • Flinn, I.W.1    Byrd, J.C.2    Morrison, C.3
  • 25
    • 24944566909 scopus 로고    scopus 로고
    • Sequential therapy with fludarabine, high dose cyclophosphamide, and rituximab induces a high incidence of complete response in patients with chronic lymphocytic leukemia
    • Lamanna N, Weiss MA, Maslak PG, et al.: Sequential therapy with fludarabine, high dose cyclophosphamide, and rituximab induces a high incidence of complete response in patients with chronic lymphocytic leukemia. Blood 2003, 102:1603a.
    • (2003) Blood , vol.102
    • Lamanna, N.1    Weiss, M.A.2    Maslak, P.G.3
  • 26
    • 0034667537 scopus 로고    scopus 로고
    • Cladribine with prednisone versus chlorambucil with prednisone as first-line therapy in chronic lymphocytic leukemia: Report of a prospective, randomized, multicenter trial
    • Robak T, Blonski J, Kasznicki M, et al.: Cladribine with prednisone versus chlorambucil with prednisone as first-line therapy in chronic lymphocytic leukemia: report of a prospective, randomized, multicenter trial. Blood 2000, 96:2723-2729.
    • (2000) Blood , vol.96 , pp. 2723-2729
    • Robak, T.1    Blonski, J.2    Kasznicki, M.3
  • 27
    • 0038514130 scopus 로고    scopus 로고
    • Pentostatin and cyclophosphamide: An effective new regimen in previously treated patients with chronic lymphocytic leukemia
    • Weiss MA, Maslak PG, Jurcic JG, et al.: Pentostatin and cyclophosphamide: an effective new regimen in previously treated patients with chronic lymphocytic leukemia. J Clin Oncol 2003, 21:1278-1284.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 1278-1284
    • Weiss, M.A.1    Maslak, P.G.2    Jurcic, J.G.3
  • 28
    • 26044451625 scopus 로고    scopus 로고
    • Pentostatin and cyclophosphamide with or without rituximab has significant activity in patients with previously treated chronic lymphocytic leukemia and other low grade lymphoid neoplasms
    • Lamanna N, Kalycio M, Maslak P, et al.: Pentostatin and cyclophosphamide with or without rituximab has significant activity in patients with previously treated chronic lymphocytic leukemia and other low grade lymphoid neoplasms. Blood 2004, 104:3484a.
    • (2004) Blood , vol.104
    • Lamanna, N.1    Kalycio, M.2    Maslak, P.3
  • 29
    • 24344483414 scopus 로고    scopus 로고
    • Combination chemotherapy with pentostatin, cyclophosphamide, and rituximab induces high rate of remissions including complete responses and achievement of minimal residual disease in previously untreated B-chronic lymphocytic leukemia
    • Kay NE, Geyer SM, Lin T, et al.: Combination chemotherapy with pentostatin, cyclophosphamide, and rituximab induces high rate of remissions including complete responses and achievement of minimal residual disease in previously untreated B-chronic lymphocytic leukemia. Blood 2004, 104:339a.
    • (2004) Blood , vol.104
    • Kay, N.E.1    Geyer, S.M.2    Lin, T.3
  • 30
    • 0033968522 scopus 로고    scopus 로고
    • European phase II study of rituximab (chimeric anti-CD 20 monoclonal antibody for patients with newly diagnosed mantle-cell lymphoma and previously treated mantle-cell lymphoma, immunocytoma, and small B-cell lymphocytic lymphoma
    • Foran JM, Rohatiner AZS, Cunningham D, et al.: European phase II study of rituximab (chimeric anti-CD 20 monoclonal antibody for patients with newly diagnosed mantle-cell lymphoma and previously treated mantle-cell lymphoma, immunocytoma, and small B-cell lymphocytic lymphoma. J Clin Oncol 2000, 18:317-324.
    • (2000) J. Clin. Oncol. , vol.18 , pp. 317-324
    • Foran, J.M.1    Rohatiner, A.Z.S.2    Cunningham, D.3
  • 31
    • 0035469851 scopus 로고    scopus 로고
    • Rituximab therapy of patients with B-cell chronic lymphocytic leukemia
    • Huhn D, von Schilling C, Wilhelm M, et al.: Rituximab therapy of patients with B-cell chronic lymphocytic leukemia. Blood 2001, 98:1326-1331.
    • (2001) Blood , vol.98 , pp. 1326-1331
    • Huhn, D.1    von Schilling, C.2    Wilhelm, M.3
  • 32
    • 0036757311 scopus 로고    scopus 로고
    • Standard-dose anti-CD20 antibody rituximab, has efficacy in chronic lymphocytic leukemia: Results from a Nordic multicentre study
    • Itala M, Geisler CH, Kimby E, et al.: Standard-dose anti-CD20 antibody rituximab, has efficacy in chronic lymphocytic leukemia: results from a Nordic multicentre study. Eur J Haematol 2002, 69:129-134.
    • (2002) Eur. J. Haematol. , vol.69 , pp. 129-134
    • Itala, M.1    Geisler, C.H.2    Kimby, E.3
  • 33
    • 0032791210 scopus 로고    scopus 로고
    • Extended rituximab (anti-CD20 monoclonal antibody) therapy for relapsed or refractory low-grade or follicular non-Hodgkin's lymphoma
    • Piro LD, White CA, Grillo-Lopez AJ, et al.: Extended rituximab (anti-CD20 monoclonal antibody) therapy for relapsed or refractory low-grade or follicular non-Hodgkin's lymphoma. Ann Oncol 1999, 10:655-661.
    • (1999) Ann. Oncol. , vol.10 , pp. 655-661
    • Piro, L.D.1    White, C.A.2    Grillo-Lopez, A.J.3
  • 34
    • 0035871441 scopus 로고    scopus 로고
    • Rituximab dose-escalation trial in chronic lymphocytic leukemia
    • O'Brien SM, Kantarjian H, Thomas DA, et al.: Rituximab dose-escalation trial in chronic lymphocytic leukemia. J Clin Oncol 2001, 19:2165-2170.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 2165-2170
    • O'Brien, S.M.1    Kantarjian, H.2    Thomas, D.A.3
  • 35
    • 0035871445 scopus 로고    scopus 로고
    • Rituximab, using a thrice weekly dosing schedule in B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma demonstrates clinical activity and acceptable toxicity
    • Byrd JD, Murphy T, Howard RS, et al.: Rituximab, using a thrice weekly dosing schedule in B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma demonstrates clinical activity and acceptable toxicity. J Clin Oncol 2001, 19:2153-2164.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 2153-2164
    • Byrd, J.D.1    Murphy, T.2    Howard, R.S.3
  • 36
    • 0038811776 scopus 로고    scopus 로고
    • Single-agent rituximab as first-line and maintenance treatment for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma: A phase II trial of the Minnie Pearl Cancer Research Network
    • Hainsworth JD, Litchy S, Barton JH, et al.: Single-agent rituximab as first-line and maintenance treatment for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma: a phase II trial of the Minnie Pearl Cancer Research Network. J Clin Oncol 2002, 21:1746-1751.
    • (2002) J. Clin. Oncol. , vol.21 , pp. 1746-1751
    • Hainsworth, J.D.1    Litchy, S.2    Barton, J.H.3
  • 37
    • 0037220152 scopus 로고    scopus 로고
    • Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab, in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: Results from Cancer and Leukemia Group B 9712 (CALGB 9712)
    • Byrd JC, Peterson BL, Morrison VA, et al.: Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab, in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: results from Cancer and Leukemia Group B 9712 (CALGB 9712). Blood 2003, 101:6-14.
    • (2003) Blood , vol.101 , pp. 6-14
    • Byrd, J.C.1    Peterson, B.L.2    Morrison, V.A.3
  • 38
    • 0037092951 scopus 로고    scopus 로고
    • Therapeutic role of alemtuzumab (Campath-1H) in patients who failed fludarabine: Results of a large international study
    • Keating MJ, Flinn I, Jain V, et al.: Therapeutic role of alemtuzumab (Campath-1H) in patients who failed fludarabine: results of a large international study. Blood 2002, 99:3554-3561.
    • (2002) Blood , vol.99 , pp. 3554-3561
    • Keating, M.J.1    Flinn, I.2    Jain, V.3
  • 39
    • 0036683449 scopus 로고    scopus 로고
    • Phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL)
    • Lundin J, Kimby E, Bjorkholm M, et al.: Phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL). Blood 2002, 100:768-773.
    • (2002) Blood , vol.100 , pp. 768-773
    • Lundin, J.1    Kimby, E.2    Bjorkholm, M.3
  • 40
    • 0344236261 scopus 로고    scopus 로고
    • Alemtuzumab as treatment for residual disease after chemotherapy in patients with chronic lymphocytic leukemia
    • O'Brien S, Kantarjian HM, Thomas DA, et al.: Alemtuzumab as treatment for residual disease after chemotherapy in patients with chronic lymphocytic leukemia. Cancer 2003, 98:2657-2663.
    • (2003) Cancer , vol.98 , pp. 2657-2663
    • O'Brien, S.1    Kantarjian, H.M.2    Thomas, D.A.3
  • 41
    • 0037860441 scopus 로고    scopus 로고
    • A phase II trial of fludarabine followed by alemtuzumab (Campath-1H) in previously untreated chronic lymphocytic leukemia patients with active disease: Cancer and Leukemia Group B (CALGB) Study 19901
    • Rai K, Byrd J, Peterson BL, Larson RA: A phase II trial of fludarabine followed by alemtuzumab (Campath-1H) in previously untreated chronic lymphocytic leukemia patients with active disease: Cancer and Leukemia Group B (CALGB) Study 19901. Blood 2002, 100:205a.
    • (2002) Blood , vol.100
    • Rai, K.1    Byrd, J.2    Peterson, B.L.3    Larson, R.A.4
  • 42
    • 0038724252 scopus 로고    scopus 로고
    • Experience with alemtuzumab plus rituximab, in patients with relapsed and refractory lymphoid malignancies
    • Faderl S, Thomas DA, O'Brien S, et al.: Experience with alemtuzumab plus rituximab, in patients with relapsed and refractory lymphoid malignancies. Blood 2003, 101:3413-3415.
    • (2003) Blood , vol.101 , pp. 3413-3415
    • Faderl, S.1    Thomas, D.A.2    O'Brien, S.3
  • 43
    • 0040932434 scopus 로고    scopus 로고
    • The novel cyclin-dependent kinase inhibitor flavopiridol downregulates Bcl-d and induces growth arrest and apoptosis in chronic B-cell leukemia lines
    • Konig A, Schwartz GK, Mohammad RM, Al-Katib A, Gabrilove JL: The novel cyclin-dependent kinase inhibitor flavopiridol downregulates Bcl-d and induces growth arrest and apoptosis in chronic B-cell leukemia lines. Blood 1997, 90:4307-4312.
    • (1997) Blood , vol.90 , pp. 4307-4312
    • Konig, A.1    Schwartz, G.K.2    Mohammad, R.M.3    Al-Katib, A.4    Gabrilove, J.L.5
  • 44
    • 0032533599 scopus 로고    scopus 로고
    • Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-3 modulation or dependent on functional p53
    • Byrd JC, Shinn C, Waselenko JK, et al.: Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-3 modulation or dependent on functional p53. Blood 1997, 92:3804-3816.
    • (1997) Blood , vol.92 , pp. 3804-3816
    • Byrd, J.C.1    Shinn, C.2    Waselenko, J.K.3
  • 45
    • 19044366065 scopus 로고    scopus 로고
    • Flavopiridol administered as a pharmacologically-derived schedule demonstrates marked clinical activity in refractory, genetically high risk, chronic lymphocytic leukemia (CLL)
    • Byrd JC, Lin TS, Dalton JT, et al.: Flavopiridol administered as a pharmacologically-derived schedule demonstrates marked clinical activity in refractory, genetically high risk, chronic lymphocytic leukemia (CLL). Blood 2004, 104:341a.
    • (2004) Blood , vol.104
    • Byrd, J.C.1    Lin, T.S.2    Dalton, J.T.3
  • 46
    • 2942569721 scopus 로고    scopus 로고
    • Interim results from a phase I study of lumiliximab, (IDEC-152, anti-CD23 antibody) therapy for relapsed or refractory CLL
    • Byrd JC, O'Brien S, Flinn I, et al.: Interim results from a phase I study of lumiliximab, (IDEC-152, anti-CD23 antibody) therapy for relapsed or refractory CLL. Blood 2003, 102:248a.
    • (2003) Blood , vol.102
    • Byrd, J.C.1    O'Brien, S.2    Flinn, I.3
  • 47
    • 0013253465 scopus 로고    scopus 로고
    • Genasense (Bcl-2 Antisense) monotherapy in patients with relapsed or refractory chronic lymphocytic leukemia: Phase 1 and 2 results
    • Rai KR, O'Brien S, Cunningham C, et al.: Genasense (Bcl-2 Antisense) monotherapy in patients with relapsed or refractory chronic lymphocytic leukemia: phase 1 and 2 results. Blood 2002, 20:1490a.
    • (2002) Blood , vol.20
    • Rai, K.R.1    O'Brien, S.2    Cunningham, C.3
  • 48
    • 20344387097 scopus 로고    scopus 로고
    • Phase 3 randomized trial of fludarabine/cyclophosphamide chemotherapy with or without oblimersen sodium (Bcl-2 antisense, Genasense, G3139) for patients with relapsed or refractory chronic lymphocytic leukemia (CLL)
    • Rai KR, Moore JO, Boyd TE, et al.: Phase 3 randomized trial of fludarabine/cyclophosphamide chemotherapy with or without oblimersen sodium (Bcl-2 antisense, Genasense, G3139) for patients with relapsed or refractory chronic lymphocytic leukemia (CLL). Blood 2004, 104:338a.
    • (2004) Blood , vol.104
    • Rai, K.R.1    Moore, J.O.2    Boyd, T.E.3
  • 49
    • 0034329352 scopus 로고    scopus 로고
    • CD40-ligand (CD154) gene therapy for chronic lymphocytic leukemia
    • Wierda WG, Cantwell MJ, Woods SJ, et al.: CD40-ligand (CD154) gene therapy for chronic lymphocytic leukemia. Blood 2000, 96:2917-2924.
    • (2000) Blood , vol.96 , pp. 2917-2924
    • Wierda, W.G.1    Cantwell, M.J.2    Woods, S.J.3
  • 50
    • 0037348324 scopus 로고    scopus 로고
    • Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD-80 and interleukin-15
    • Brentjens RJ, Latouche JB, Santos E, et al.: Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD-80 and interleukin-15. Nat Med 2003, 9:279-286.
    • (2003) Nat. Med. , vol.9 , pp. 279-286
    • Brentjens, R.J.1    Latouche, J.B.2    Santos, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.