메뉴 건너뛰기




Volumn 11, Issue 5, 2005, Pages 368-372

Anticoagulation therapy in the antiphospholipid syndrome: Recent advances

Author keywords

Antiphospholipid antibodies; Oral anticoagulants; Pregnancy; Pregnancy loss; Thrombosis

Indexed keywords

ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT; ANTIVITAMIN K; CARDIOLIPIN ANTIBODY; PHOSPHOLIPID ANTIBODY; WARFARIN;

EID: 24744459638     PISSN: 10705287     EISSN: 15316971     Source Type: Journal    
DOI: 10.1097/01.mcp.0000174229.24854.2e     Document Type: Review
Times cited : (6)

References (35)
  • 1
    • 0034924140 scopus 로고    scopus 로고
    • International classification criteria for antiphospholipid syndrome: Synopsis of a post-conference workshop held at the Ninth International (Tours) aPL Symposium
    • Wilson WA, Gharavi AE, Piette JC. International classification criteria for antiphospholipid syndrome: synopsis of a post-conference workshop held at the Ninth International (Tours) aPL Symposium. Lupus 2001; 10:457-460.
    • (2001) Lupus , vol.10 , pp. 457-460
    • Wilson, W.A.1    Gharavi, A.E.2    Piette, J.C.3
  • 3
    • 0031919292 scopus 로고    scopus 로고
    • Anticardiolipin antibodies predict early recurrence of thromboembolism and death among patients with venous thromboembolism following anticoagulant therapy
    • Duration of Anticoagulation Study Group
    • Schulman S, Svenungsson E, Granqvist S. Anticardiolipin antibodies predict early recurrence of thromboembolism and death among patients with venous thromboembolism following anticoagulant therapy. Duration of Anticoagulation Study Group. Am J Med 1998; 104:332-338.
    • (1998) Am J Med , vol.104 , pp. 332-338
    • Schulman, S.1    Svenungsson, E.2    Granqvist, S.3
  • 4
    • 0026659095 scopus 로고
    • Antiphospholipid thrombosis: Clinical course after the first thrombotic event in 70 patients
    • Rosove MH, Brewer PM. Antiphospholipid thrombosis: clinical course after the first thrombotic event in 70 patients. Ann Intern Med 1992; 117:303-308.
    • (1992) Ann Intern Med , vol.117 , pp. 303-308
    • Rosove, M.H.1    Brewer, P.M.2
  • 5
    • 0027203896 scopus 로고
    • Patients with antiphospholipid antibodies and venous thrombosis should receive long-term anticoagulant treatment
    • Derksen RH, de Groot PG, Kater L, Nieuwenhuis HK. Patients with antiphospholipid antibodies and venous thrombosis should receive long-term anticoagulant treatment. Ann Rheum Dis 1993; 52:689-692.
    • (1993) Ann Rheum Dis , vol.52 , pp. 689-692
    • Derksen, R.H.1    De Groot, P.G.2    Kater, L.3    Nieuwenhuis, H.K.4
  • 6
    • 0028908094 scopus 로고
    • The management of thrombosis in the antiphospholipid-antibody syndrome
    • Khamashta MA, Cuadrado MJ, Mujic F, et al. The management of thrombosis in the antiphospholipid-antibody syndrome. N Engl J Med 1995; 332:993-997.
    • (1995) N Engl J Med , vol.332 , pp. 993-997
    • Khamashta, M.A.1    Cuadrado, M.J.2    Mujic, F.3
  • 7
    • 9644270402 scopus 로고    scopus 로고
    • Evidence based treatment for the antiphospholipid antibody syndrome II: Optimal anticoagulant therapy for thrombosis
    • Crowther MA, Wisloff F. Evidence based treatment for the antiphospholipid antibody syndrome II: optimal anticoagulant therapy for thrombosis. Thromb Res 2005; 115:3-8.
    • (2005) Thromb Res , vol.115 , pp. 3-8
    • Crowther, M.A.1    Wisloff, F.2
  • 8
    • 0036781795 scopus 로고    scopus 로고
    • Antiphospholipid antibodies and stroke in young women
    • comment
    • Brey RL, Stallworth CL, McGlasson DL, et al. Antiphospholipid antibodies and stroke in young women. Stroke 2002; 33:2396-2401. [comment]
    • (2002) Stroke , vol.33 , pp. 2396-2401
    • Brey, R.L.1    Stallworth, C.L.2    McGlasson, D.L.3
  • 9
    • 0034884321 scopus 로고    scopus 로고
    • Beta(2)-Glycoprotein 1-dependent anticardiolipin antibodies and risk of ischemic stroke and myocardial infarction: The Honolulu Heart Program
    • Brey RL, Abbott RD, Curb JD, et al. beta(2)-Glycoprotein 1-dependent anticardiolipin antibodies and risk of ischemic stroke and myocardial infarction: the Honolulu Heart Program. Stroke 2001; 32:1701-1706.
    • (2001) Stroke , vol.32 , pp. 1701-1706
    • Brey, R.L.1    Abbott, R.D.2    Curb, J.D.3
  • 10
    • 10744223871 scopus 로고    scopus 로고
    • Antiphospholipid antibodies and subsequent thrombo-occlusive events in patients with ischemic stroke
    • Levine SR, Brey RL, Tilley BC, et al. Antiphospholipid antibodies and subsequent thrombo-occlusive events in patients with ischemic stroke. JAMA 2004; 291(5):576-584. In this prospective cohort study within the Warfarin vs Aspirin Recurrent Stroke Study, 1 770 patients were tested for APLa and monitored for 2 years for recurrent thrombo-occlusive events. The presence of APLa did not predict either an increase risk for subsequent vascular occlusive events or a differential response to warfarin or aspirin therapy.
    • (2004) JAMA , vol.291 , Issue.5 , pp. 576-584
    • Levine, S.R.1    Brey, R.L.2    Tilley, B.C.3
  • 11
    • 0033594503 scopus 로고    scopus 로고
    • Anticardiolipin antibodies and their associations with cerebrovascular risk factors
    • Tanne D, D'Olhaberriague L, Schultz LR, et al. Anticardiolipin antibodies and their associations with cerebrovascular risk factors. Neurology 1999; 52:1368-1373.
    • (1999) Neurology , vol.52 , pp. 1368-1373
    • Tanne, D.1    D'Olhaberriague, L.2    Schultz, L.R.3
  • 12
    • 0026597320 scopus 로고
    • Antiphospholipid antibodies after myocardial infarction and their relation to mortality, reinfarction, and non-haemorrhagic stroke
    • see comments
    • Sletnes KE, Smith P, Abdelnoor M, et al. Antiphospholipid antibodies after myocardial infarction and their relation to mortality, reinfarction, and non-haemorrhagic stroke. Lancet 1992; 339:451-453. (see comments).
    • (1992) Lancet , vol.339 , pp. 451-453
    • Sletnes, K.E.1    Smith, P.2    Abdelnoor, M.3
  • 13
    • 0033609462 scopus 로고    scopus 로고
    • Antiphospholipid antibodies are a risk factor for early renal allograft failure
    • Wagenknecht DR, Becker DG, LeFor WM, McIntyre JA. Antiphospholipid antibodies are a risk factor for early renal allograft failure. Transplantation 1999; 68:241-246.
    • (1999) Transplantation , vol.68 , pp. 241-246
    • Wagenknecht, D.R.1    Becker, D.G.2    Lefor, W.M.3    McIntyre, J.A.4
  • 14
    • 0031663955 scopus 로고    scopus 로고
    • Relative risk of post-transplant renal thrombosis in patients with antiphospholipid antibodies
    • Vaidya S, Wang CC, Gugliuzza C, Fish JC. Relative risk of post-transplant renal thrombosis in patients with antiphospholipid antibodies. Clin Transplant 1998; 12:439-444.
    • (1998) Clin Transplant , vol.12 , pp. 439-444
    • Vaidya, S.1    Wang, C.C.2    Gugliuzza, C.3    Fish, J.C.4
  • 15
    • 7244257721 scopus 로고    scopus 로고
    • Significance of anticardiolipin antibodies on short and long term allograft survival and function following kidney transplantation
    • Forman JP, Lin J, Pascual M, et al. Significance of anticardiolipin antibodies on short and long term allograft survival and function following kidney transplantation. Am J Transplant 2004; 4(11):1786-1791. A cohort of 337 patients undergoing renal transplantation were tested for aCL and monitored during the end of the study period. Although there was no difference in outcome (allograft loss or worsening of renal function) between antibody-positive and -negative patients, subgroups of patients with high titers or APS clearly benefited from anticoagulation.
    • (2004) Am J Transplant , vol.4 , Issue.11 , pp. 1786-1791
    • Forman, J.P.1    Lin, J.2    Pascual, M.3
  • 16
    • 0141791073 scopus 로고    scopus 로고
    • A randomized trial of two intensities of warfarin (international normalized ratio of 2.0 to 3.0 versus 3.1 to 4.0) for the prevention of recurrent thrombosis in patients with antiphospholipid antibodies
    • Crowther MA, Ginsberg JS, Gent M, et al. A randomized trial of two intensities of warfarin (international normalized ratio of 2.0 to 3.0 versus 3.1 to 4.0) for the prevention of recurrent thrombosis in patients with antiphospholipid antibodies. N Engl J Med 2003; 349:1133-1138.
    • (2003) N Engl J Med , vol.349 , pp. 1133-1138
    • Crowther, M.A.1    Ginsberg, J.S.2    Gent, M.3
  • 17
    • 23844437705 scopus 로고    scopus 로고
    • A randomized clinical trial of high-intensity warfarin vs. conventional antithrombotic therapy for the prevention of recurrent thrombosis in patients with the antiphospholipid syndrome (WAPS)
    • Finazzi G, Marchioli R, Barbui T, et al. A randomized clinical trial of high-intensity warfarin vs. conventional antithrombotic therapy for the prevention of recurrent thrombosis in patients with the antiphospholipid syndrome (WAPS). J Thromb Haemost 2005; 3:848-853.
    • (2005) J Thromb Haemost , vol.3 , pp. 848-853
    • Finazzi, G.1    Marchioli, R.2    Barbui, T.3
  • 18
    • 0036192682 scopus 로고    scopus 로고
    • Longterm anticoagulation is preferable for patients with antiphospholipid antibody syndrome: Result of a decision analysis
    • Brunner HI, Chan WS, Ginsberg JS, Feldman BM. Longterm anticoagulation is preferable for patients with antiphospholipid antibody syndrome: result of a decision analysis. J Rheumatol 2002; 29:490-501.
    • (2002) J Rheumatol , vol.29 , pp. 490-501
    • Brunner, H.I.1    Chan, W.S.2    Ginsberg, J.S.3    Feldman, B.M.4
  • 19
    • 0031730979 scopus 로고    scopus 로고
    • Management of thrombosis and pregnancy loss in the antiphospholipid syndrome
    • Khamashta MA. Management of thrombosis and pregnancy loss in the antiphospholipid syndrome. Lupus 1998; 7(Suppl 2):S162-S165.
    • (1998) Lupus , vol.7 , Issue.SUPPL. 2
    • Khamashta, M.A.1
  • 20
    • 4644221063 scopus 로고    scopus 로고
    • Antithrombotic therapy for venous thromboembolic disease: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy
    • Buller HR, Agnelli G, Hull RD, et al. Antithrombotic therapy for venous thromboembolic disease: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 2004; 126:4013-4285. This latest evidence-based guideline provides recommendation for the intensity and duration of warfarin therapy for APS patients.
    • (2004) Chest , vol.126 , pp. 4013-4285
    • Buller, H.R.1    Agnelli, G.2    Hull, R.D.3
  • 21
    • 0020035790 scopus 로고
    • Decidual vasculopathy and extensive placental infarction in a patient with repeated thromboembolic accidents, recurrent fetal loss, and a lupus anticoagulant
    • De Wolf F, Carreras LO, Moerman P, Renaer M, et al. Decidual vasculopathy and extensive placental infarction in a patient with repeated thromboembolic accidents, recurrent fetal loss, and a lupus anticoagulant. Am J Obstet Gynecol 1982; 142:829-834.
    • (1982) Am J Obstet Gynecol , vol.142 , pp. 829-834
    • De Wolf, F.1    Carreras, L.O.2    Moerman, P.3    Renaer, M.4
  • 22
    • 0034121236 scopus 로고    scopus 로고
    • Antiphospholipid antibodies affect trophoblast gonadotropin secretion and invasiveness by binding directly and through adhered beta2-glycoprotein I
    • di Somone N, Meroni PL, de Papa N, et al. Antiphospholipid antibodies affect trophoblast gonadotropin secretion and invasiveness by binding directly and through adhered beta2-glycoprotein I. Arthritis Rheum 2000; 43:140-150.
    • (2000) Arthritis Rheum , vol.43 , pp. 140-150
    • Di Somone, N.1    Meroni, P.L.2    De Papa, N.3
  • 23
    • 0037148520 scopus 로고    scopus 로고
    • Complement C3 activation is required for antiphospholipid antibody-induced fetal loss
    • Holers VM, Girardi G, Mo L, et al. Complement C3 activation is required for antiphospholipid antibody-induced fetal loss. J Exp Med 2002; 195:211-220.
    • (2002) J Exp Med , vol.195 , pp. 211-220
    • Holers, V.M.1    Girardi, G.2    Mo, L.3
  • 24
    • 0346969977 scopus 로고    scopus 로고
    • Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome
    • Girardi G, Berman J, Redecha P, et al. Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome. J Clin Invest 2003; 112:1644-1654.
    • (2003) J Clin Invest , vol.112 , pp. 1644-1654
    • Girardi, G.1    Berman, J.2    Redecha, P.3
  • 25
    • 9144243607 scopus 로고    scopus 로고
    • Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activation
    • Girardi G, Redecha P, Salmon JE. Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activation. Nat Med 2004; 10(11):1222-1226. In this study based on a murine model, prevention of pregnancy loss by heparin was postulated to be due to inhibition of complement activation rather than to its anticoagulant effect.
    • (2004) Nat Med , vol.10 , Issue.11 , pp. 1222-1226
    • Girardi, G.1    Redecha, P.2    Salmon, J.E.3
  • 26
    • 0036145638 scopus 로고    scopus 로고
    • Recurrent pregnancy loss with antiphospholipid antibody: A systematic review of therapeutic trials
    • Empson M, Lassere M, Craig JC, Scott JR. Recurrent pregnancy loss with antiphospholipid antibody: a systematic review of therapeutic trials. Obstet Gynecol 2002; 99:135-144.
    • (2002) Obstet Gynecol , vol.99 , pp. 135-144
    • Empson, M.1    Lassere, M.2    Craig, J.C.3    Scott, J.R.4
  • 27
    • 4043139308 scopus 로고    scopus 로고
    • Evidence-based treatment of the antiphospholipid syndrome: I. Pregnancy failure
    • Wisloff F, Crowther M. Evidence-based treatment of the antiphospholipid syndrome: I. Pregnancy failure. Thromb Res 2004; 114:75-81.
    • (2004) Thromb Res , vol.114 , pp. 75-81
    • Wisloff, F.1    Crowther, M.2
  • 28
    • 0030746019 scopus 로고    scopus 로고
    • Prednisone and aspirin in women with autoantibodies and unexplained recurrent fetal loss
    • Laskin CA, Bombardier C, Hannah ME, et al. Prednisone and aspirin in women with autoantibodies and unexplained recurrent fetal loss. N Engl J Med 1997; 337:148-153.
    • (1997) N Engl J Med , vol.337 , pp. 148-153
    • Laskin, C.A.1    Bombardier, C.2    Hannah, M.E.3
  • 29
    • 0037334440 scopus 로고    scopus 로고
    • Randomized study of subcutaneous low molecular weight heparin plus aspirin versus intravenous immunoglobulin in the treatment of recurrent fetal loss associated with antiphospholipid antibodies
    • Triolo G, Ferrante A, Ciccia F, et al. Randomized study of subcutaneous low molecular weight heparin plus aspirin versus intravenous immunoglobulin in the treatment of recurrent fetal loss associated with antiphospholipid antibodies. Arthritis Rheum 2003; 48(3):728-731.
    • (2003) Arthritis Rheum , vol.48 , Issue.3 , pp. 728-731
    • Triolo, G.1    Ferrante, A.2    Ciccia, F.3
  • 30
    • 0031022366 scopus 로고    scopus 로고
    • Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies)
    • Rai R, Cohen H, Dave M, Regan L. Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies). BMJ 1997; 314:253-257.
    • (1997) BMJ , vol.314 , pp. 253-257
    • Rai, R.1    Cohen, H.2    Dave, M.3    Regan, L.4
  • 31
    • 0029934389 scopus 로고    scopus 로고
    • Antiphospholipid antibody-associated recurrent pregnancy loss: Treatment with heparin and low-dose aspirin is superior to low- dose aspirin alone
    • Kutteh WH. Antiphospholipid antibody-associated recurrent pregnancy loss: treatment with heparin and low-dose aspirin is superior to low- dose aspirin alone. Am J Obstet Gynecol 1996; 174:1584-1589.
    • (1996) Am J Obstet Gynecol , vol.174 , pp. 1584-1589
    • Kutteh, W.H.1
  • 32
    • 0032724913 scopus 로고    scopus 로고
    • Thromboprophylaxis with low molecular weight heparin (dalteparin) in pregnancy
    • Pettila V, Kaaja R, Leinonen P, et al. Thromboprophylaxis with low molecular weight heparin (dalteparin) in pregnancy. Thromb Res 1999; 96:275-282.
    • (1999) Thromb Res , vol.96 , pp. 275-282
    • Pettila, V.1    Kaaja, R.2    Leinonen, P.3
  • 33
    • 14844286167 scopus 로고    scopus 로고
    • Antiphospholipid antibodies associated with recurrent pregnancy loss: Prospective, multicenter, controlled pilot study comparing treatment with low-molecular-weight heparin versus unfractionated heparin
    • Noble LS, Kutteh WH, Lashey N, et al. Antiphospholipid antibodies associated with recurrent pregnancy loss: prospective, multicenter, controlled pilot study comparing treatment with low-molecular-weight heparin versus unfractionated heparin. Fertil Steril 2005; 83:684-690. The use of LMWH with aspirin seems to be as safe as UFH with aspirin, according to this pilot study.
    • (2005) Fertil Steril , vol.83 , pp. 684-690
    • Noble, L.S.1    Kutteh, W.H.2    Lashey, N.3
  • 34
    • 14744268678 scopus 로고    scopus 로고
    • Efficacy and safety of nadroparin in the treatment of pregnant women with antiphospholipid syndrome: A prospective cohort study
    • Ruffatti A, Favaro M, Tonello M, et al. Efficacy and safety of nadroparin in the treatment of pregnant women with antiphospholipid syndrome: a prospective cohort study. Lupus 2005; 14(2):120-128. More than 90% live births were reported in this study, which used twice-daily nadroparin in the treatment of patients with APS.
    • (2005) Lupus , vol.14 , Issue.2 , pp. 120-128
    • Ruffatti, A.1    Favaro, M.2    Tonello, M.3
  • 35
    • 0036711316 scopus 로고    scopus 로고
    • Antiphospholipid syndrome in pregnancy: A randomized, controlled trial of treatment
    • Farquharson RG, Quenby S, Greaves M. Antiphospholipid syndrome in pregnancy: a randomized, controlled trial of treatment. Obstet Gynecol 2002; 100:408-413.
    • (2002) Obstet Gynecol , vol.100 , pp. 408-413
    • Farquharson, R.G.1    Quenby, S.2    Greaves, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.