Efficacy, safety and tolerability of sildenafil in Brazilian hypertensive patients on multiple antihypertensive drugs

International Braz J Urol

Volumn 31, Issue 4, 2005, Pages 342-355

  Albuquerque, Denilson Campos ^a,g   Miziara, Lineu J ^b   Saraiva, Jose F K ^c   Rodrigues, Ulisses S ^d   Ribeiro, Artur B ^e   Wajngarten, Mauricio ^f  

^a STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b FEDERAL UNIVERSITY OF UBERLÂNDIA   (Brazil)

^c PONTIFÍCIA UNIVERSIDADE CATÓLICA DE CAMPINAS   (Brazil)

^d Hospital Municipal Salgado Filho   (Brazil)

^e FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^f UNIVERSITY OF SÃO PAULO   (Brazil)

^g NONE   (Brazil)

Author keywords

Anti hypertension drugs; Erectile dysfunctin; Hypertension; Sildenafil

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ANTIHYPERTENSIVE AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; PLACEBO; SILDENAFIL;

ABDOMINAL PAIN; ADULT; AGED; ANTIHYPERTENSIVE THERAPY; ARTICLE; BLOOD PRESSURE REGULATION; BRAZIL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DISEASE EXACERBATION; DIZZINESS; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; DRUG TOLERABILITY; DYSPEPSIA; ERECTILE DYSFUNCTION; FLU LIKE SYNDROME; FLUSHING; HEADACHE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PARESTHESIA; PATIENT SATISFACTION; RANDOMIZED CONTROLLED TRIAL; RHINITIS; SIDE EFFECT; THORAX PAIN; VASODILATATION;

EID: 24744454005     PISSN: 16775538     EISSN: None     Source Type: Journal    
DOI: 10.1590/S1677-55382005000400008     Document Type: Article

References (27)

1. NIH Consensus Conference. Impotence. NIH Consensus Development Panel on Impotence. JAMA. 1993; 270: 83-90.
2. Rosen RC, Fisher WA, Eardley I, Niederberger C, Nadel A, Sand M, et al.: The multinational Men's Attitudes to Life Events and Sexuality (MALES) study: I. Prevalence of erectile dysfunction and related health concerns in the general population. Curr Med Res Opin. 2004; 20: 607-17.
3. Moreira ED Jr, Lobo CF, Diament A, Nicolosi A, Glasser DB: Incidence of erectile dysfunction in men 40 to 69 years old: results from a population-based cohort study in Brazil. Urology. 2003; 61: 431-6.
4. Mion D Jr, Nobre F, Kohlmann O, Jr, Machado CA, Gomes MAM, Amodeo C, et al.: IV Brazilian Guideline in Arterial Hypertension [in Portuguese]. (2002) Available at http://www.sbh.org.br/documentos/index.asp (accessed 19 October 2004).
5. Seftel AD, Sun P, Swindle R: The prevalence of hypertension, hyperlipidemia, diabetes mellitus and depression in men with erectile dysfunction. J Urol. 2004; 171: 2341-5.
6. Feldman HA, Johannes CB, Derby CA, Kleinman KP, Mohr BA, Araujo AB, et al.: Erectile dysfunction and coronary risk factors: prospective results from the Massachusetts Male Aging Study. Prev Med. 2000; 30: 328-38.
7. Chew KK, Earle CM, Stuckey BG, Jamrozik K, Keogh EJ: Erectile dysfunction in general medicine practice: prevalence and clinical correlates. Int J Import Res. 2000; 12: 41-5.
8. Goldstein I, Lue TF, Padma-Nathan H, Rosen RC, Steers WD, Wicker PA: Oral sildenafil in the treatment of erectile dysfunction. Sildenafil Study Group. N Engl J Med. 1998; 338: 1397-404. Erratum in: N Engl J Med 1998; 339: 59.
9. Moore RA, Edwards JE, McQuay HJ: Sildenafil (Viagra) for erectile dysfunction: a meta-analysis of clinical trial reports. BMC Urol. 2002; 2: 6.
10. Glina S, Bertero E, Claro JA, Damiao R, Faria G, Fregonesi A, et al.: Efficacy and safety of flexible-dose oral sildenafil citrate (Viagra) in the treatment of erectile dysfunction in Brazilian and Mexican men. Int J Impot Res. 2002; 14 (Suppl 2): S27-S32.
11. Cheitlin MD, Hutter AM, Brindis RG, Ganz P, Kaul S, Russell RO Jr, et al.: Use of sildenafil (Viagra) in patients with cardiovascular disease. Technology and Practice Executive Committee. Circulation. 1999; 99: 168-77. Erratum in: Circulation 1999; 100: 2389.
12. Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A: The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology. 1997; 49: 822-30.
13. Lewis R, Bennett CJ, Borkon WD, Boykin WH, Althof SE, Stecher VJ, et al.: Patient and partner satisfaction with Viagra (sildenafil citrate) treatment as determined by the Erectile Dysfunction Inventory of Treatment Satisfaction Questionnaire. Urology. 2001; 57: 960-5.
14. Benet AE, Melman A: The epidemiology of erectile dysfunction. Urol Clin North Am. 1995; 22: 699-709.
15. Anderson KE, Wagner G: Physiology of penile erection. Physiol Rev. 1995; 75: 191-236.
16. Boolell M, Allen MJ, Ballard SA, Gepi-Attee S, Muirhead GJ, Naylor AM, et al.: Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. Int J Import Res. 1996; 8: 47-52.
17. Rubin A, Babbott D: Impotence and diabetes mellitus. JAMA. 1958; 168: 498-500.
18. McCulloch DK, Campbell IW, Wu FC, Prescott RJ: The prevalence of diabetic impotence. Diabetologia. 1980; 18: 279-83.
19. Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB: Impotence and its medical and psychosocial correlates: results of Massachusetts Male Aging Study. J Urol. 1994; 151: 54-61.
20. Jackson G, Benjamin N, Jackson N, Allen MJ: Effects of sildenafil citrate on human hemodynamics. Am J Cardiol. 1999; 83: 13C-20C.
21. Morales A, Gingell C, Collins M, Wicker PA, Osterloh IH: Clinical safety of oral sildenafil citrate (Viagra) in the treatment of erectile dysfunction. Int J Import Res. 1998; 10: 69-73; discussion 73-4.
22. Zusman RM, Morales A, Glasser DB, Osterloh IH: Overall cardiovascular profile of sildenafil citrate. Am J Cardiol. 1999; 83: 35C-44C.
23. Kloner RA, Zusman RM: Cardiovascular effects of sildenafil citrate and recommendations for its use. Am J Cardiol. 1999; 84: 11N-17N.
24. Zusman RM, Prisant LM, Brown MJ: Effect of sildenafil citrate on blood pressure and heart rate in men with erectile dysfunction taking concomitant antihypertensive medication. Sildenafil Study Group. Am J Hypertens. 2000; 18: 1865-9.
25. Kloner RA, Brown M, Prisant LM, Collins M: Effect of sildenafil in patients with erectile dysfunction taking antihypertensive therapy. Sildenafil Study Group. Am J Hypertens. 2001; 14: 70-3.
26. Webb DJ, Freestone S, Allen MJ, Muirhead GJ: Sildenafil citrate and blood-pressure-lowering drugs: results of drug interaction studies with an organic nitrate and a calcium antagonist. Am J Cardiol. 1999; 83: 21C-28C.
27. Kloner RA, Brown M, Sildenafil Study Group: Safety of sildenafil citrate in men with erectile dysfunction taking multiple antihypertensive agents. Am J Hypertens. 1999; 12: 37A.