Nightmares in patients with Alzheimer's disease caused by donepezil. Therapeutic effect depends on the time of intake;Albträume bei patienten mit Alzheimer-demenz durch donepezil. Therapeutischer effekt ist abhängig vom einnahmezeitpunkt

Nervenarzt

Volumn 76, Issue 9, 2005, Pages 1127-1129

  Singer, M ^a,b   Romero, B ^a,b   Koenig, E ^a   Forstl H ^b   Brunner, H ^a,c  

^a Alzheimer Therapiezentrum   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c Neurologische Klinik Bad Aibling   (Germany)

Author keywords

Alzheimer's disease; Donepezil; Morning intake; Nightmares; REM sleep

Indexed keywords

DONEPEZIL;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FEMALE; HUMAN; MALE; NIGHTMARE; TIME; TREATMENT OUTCOME;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; DREAMS; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; INDANS; MALE; MIDDLE AGED; NIGHT TERRORS; NOOTROPIC AGENTS; PIPERIDINES; TIME FACTORS; TREATMENT OUTCOME;

EID: 24744452164     PISSN: 00282804     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00115-004-1856-7     Document Type: Article

References (12)

1. Braun AR, Balkin TJ, Wesensten NJ et al. (1998) Dissociated pattern of activity in visual cortices and their projections during human rapid eye movement sleep. Science 279:91-95
2. Gottesmann C (2002) The neurochemistry of waking and sleeping mental activity: the disinhibition-dopamine hypothesis. Psychiatry Clin Neurosci 56:345-354
3. Kanbayashi T, Sugiyama T, Aizawa R et al. (2002) Effects of donepezil (Aricept) on the rapid eye movement sleep of normal subjects. Psychiatry Clin Neurosci 56:307-308
4. Krall WJ, Sramek JJ, Cutler NR (1999) Cholinesterase inhibitors: a therapeutic strategy for Alzheimer disease. Ann Pharmacother 33:441-450
5. Madsen PL, Holm S, Vorstrup S et al. (1991) Human regional cerebral blood flow during rapid-eye-movement sleep. J Cereb Blood Flow Metab 11:502-507
6. Moraes WA, Polyares DL, Ramos LR et al. (2001) Anticholinesterase drug donepezil increases REM sleep duration in Alzheimer's disease patients: Preliminary data. Sleep 24(Suppl):A369
7. Romero B, Wenz M (2003) Wirksame Behandlungsprogramme für Demenzkranke und betreuende Angehörige. Neurol Rehabil 9:23-27
8. Ross JS, Shua-Haim JR. (1998) Aricept-induced nightmares in Alzheimer's disease: 2 case reports. J Am Geriatr Soc 46:119-120
9. Sarter M, Bruno JP (2000) Cortical cholinergic inputs mediating arousal, attentional processing and dreaming: differential afferent regulation of the basal forebrain by telencephalic and brainstem afferents. Neuroscience 95:933-952
10. Schredl M, Weber B, Leins ML et al. (2001) Donepezil-induced REM sleep augmentation enhances memory performance in elderly, healthy persons. Exp Gerontol 36:353-361
11. Steriade M, McCormick DA, Sejnowski TJ (1993) Thalamocortical oscillations in the sleeping and aroused brain. Science 262:679-685
12. Tiseo PJ, Rogers SL, Friedhoff LT (1998) Pharmacokinetic and pharmacodynamic profile of donepezil HCI following evening administration. Br J Clin Pharmacol 46(Suppl 1):13-18