Dissolution, solubility, XRD, and DSC studies on flurbiprofen-nicotinamide solid dispersions

Drug Development and Industrial Pharmacy

Volumn 31, Issue 4-5, 2005, Pages 417-423

  Varma, M M ^a   Pandi, J K ^b  

^a SHRI VISHNU COLLEGE OF PHARMACY   (India)

^b BANARAS HINDU UNIVERSITY   (India)

Author keywords

Flurbiprofen; Nicotinamide; Solid dispersion

Indexed keywords

DRUG CARRIER; FLURBIPROFEN; NICOTINAMIDE; NONSTEROID ANTIINFLAMMATORY AGENT;

AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG SOLUBILITY; PHASE TRANSITION; X RAY DIFFRACTION;

CALORIMETRY, DIFFERENTIAL SCANNING; DRUG CARRIERS; DRUG COMBINATIONS; DRUG COMPOUNDING; FLURBIPROFEN; HYDROGEN-ION CONCENTRATION; NIACINAMIDE; POWDERS; SOLUBILITY; WATER; X-RAY DIFFRACTION;

EID: 24744444080     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.1080/03639040500214613     Document Type: Article

References (23)

1. Acarturk, F., Takka, S., Agabeyoglu, I., Ozkan, Y., Yalim, G., & Simsek, R. (1993). Influence of preparation method on the dissolution characteristics of ibuprofen with low-molecular gelatin. Pharmazie, 48, 761-763.
2. Babu, R. J., & Pandit, J. K. (1995). Enhancement of dissolution rate and hypoglycemic activity of glibenclamide with β-cyclodextrin. STP Pharma Sciences, 5, 196-201.
3. Bogdanova, Sv., Sidzhakova, D., Karaivanova, V., & Georgieva, Sv. (1998). Aspects of interactions between indomethacin and nicotinamide in solid dispersions. International Journal of Pharmaceutics, 163, 1-10.
4. Chen, A., Zito, S., & Nash, R. (1994). Solubility enhancement of nucleosides and structurally related compounds by complex formation. Pharmaceutical Research, 11, 398-401.
5. Chiou, W. L., & Riegelman, S. (1971). Pharmaceutical applications of solid dispersion systems. Journal of Pharmaceutical Sciences, 60, 1281-1302.
6. Chowdary, K. P. R., & Rao, P. V. (1994). Biopharmaceutical studies on solid dispersions of nalidixic acid in modified starches. Drug Development and Industrial Pharmacy, 20, 3015-3022.
7. Eshra, A., Naggar, V., & Boraie, N. (1986). A study of indomethacin-nicotinamide solid dispersions. Pharmazeutische Industrie, 48, 1557-1560.
8. Fawzi, M., Davison, E., & Tute, M. (1980). Rationalization of drug complexation in aqueous solution by use of huckel frontier molecular orbitals. Journal of Pharmaceutical Sciences, 69, 104-105.
9. Ford, J. L. (1986). The current status of solid dispersions. Pharmaceutica Acta Helvetiae, 61, 69-88.
10. Hamza, Y., Sammour, O., & Abdel Latif, H. (1994). Enhancement of dissolution and modulation of its pharmacodynamics and ulcerogenicity via solid dispersions. Pharmazeutische Industrie, 56, 286-291.
11. Herzfeldt, C. D., & Kummel, R. (1983). Dissociation constants, solubilities and dissolution rates of some selected non-steroidal anti-inflammatories. Drug Development and Industrial Pharmacy, 9, 767-793.
12. Higuchi, T., & Connors, K. A. (1965). Phase solubility techniques. In: C.N. Reilley (Ed.). Advances in Analytical Chemistry and Instrumentation, Vol. 4 (pp. 117-212). New York: Willey-Interscience.
13. Imai, T., Saito, T., Matsumoto, H., Satoh, T., & Otagiri, M. (1989). Influence of egg albumin on dissolution of several drugs. International Journal of Pharmaceutics, 53, 7-12.
14. Khan, K. A. (1975). The concept of dissolution efficiency. Journal of Pharmacy and Pharmacology, 27, 48-49.
15. Lacoulonche, F., Chauvet, A., & Masse, J. (1997). An investigation of flurbiprofen polymorphism by thermo-analytical and spectroscopic methods and a study of its interactions with poly (ethylene glycol) 6000 by differential scanning calorimetry and modelling. International Journal of Pharmaceutics, 153, 167-179.
16. Margaret, M. V., Rodriguez, I. C., & Cerezo, A. (1994). Physical characteristics and dissolution kinetics of solid dispersions of ketoprofen and polyethylene glycol, 6000. International Journal of Pharmaceutics, 108, 101-107.
17. Mummaneni, V., & Vasavada, R. C. (1990). Solubilisation and dissolution of famotidine from solid glass dispersions of xylitol. International Journal of Pharmaceutics, 66, 71-77.
18. Ozeli, T., Yuasa, H., & Kanaya, Y. (1997). Application of the solid dispersion method to the controlled release of medicine. IX. Difference in the release of flurbiprofen from solid dispersions with poly (ethylene oxide) and hydroxypropylcellulose and the interaction between medicine and polymers. International Journal of Pharmaceutics, 155, 209-217.
19. Rasool, A. A., Hussain, A. A., & Dittert, L. W. (1991). Solubility enhancement of some water-insoluble drugs in the presence of nicotinamide and related compounds. Journal of Pharmaceutical Sciences, 80, 387-393.
20. Sekiguchi, K., Obi, N., & Ueda, Y. (1964). Studies on absorption of eutectic mixture. II. Absorption of fused conglomerates of chloramphenicol and urea in rabbits. Chemical and Pharmaceutical Bulletin, 12, 134-144.
21. Truelove, J., Bawarshi-Nassar, R., Chen, N., & Hussain, A. (1984). Solubility enhancement of some developmental anticancer nucleoside analogs by complexation with nicotinamide. International Journal of Pharmaceutics, 19, 17-25.
22. United States Pharmacopoeia (1995). US Pharmacopoeial Convention Inc., 23rd Rockville, MD 20852, 689-690.
23. Verma, M. M., Kumar, M. T., Balasubramaniam, J., & Pandit, J. K. (2002). Unavailability studies on fast release formulations of indomethacin. Bollettino Chimico Farmaceutico, 141, 176-180.