Decreased whole-body and splanchnic glutamate metabolism in healthy elderly men and patients with chronic obstructive pulmonary disease in the postabsorptive state and in response to feeding

Journal of Nutrition

Volumn 135, Issue 9, 2005, Pages 2166-2170

  Rutten, Erica P A ^a   Engelen, Marielle P K J ^a   Castro, Carmen L N ^a   Wouters, Emiel F M ^a   Schols, Annemie M W J ^a   Deutz, Nicolaas E P ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Aging; Chronic obstructive pulmonary disease; Glutamate; Postabsorptive and fed states

Indexed keywords

GLUTAMIC ACID; MALTODEXTRIN; MILK PROTEIN;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; BODY COMPOSITION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; FEEDING; FOOD COMPOSITION; HUMAN; LUNG FUNCTION TEST; MALE; METABOLISM;

EID: 24744435774     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/135.9.2166     Document Type: Article

References (23)

1. Schols, A.M.W.J., Deutz, N.E.P., Mostert, R. & Wouters, E.F.M. (1993) Plasma amino acid levels in patients with chronic obstructive pulmonary disease. Monaldi Arch. Chest Dis. 48: 546-548.
2. Hofford, J. M., Milakofsky, L., Vogel, W. H., Sacher, R. S., Savage, G. J. & Pell, S. (1990) The nutritional status in advanced emphysema associated with chronic bronchitis. A study of amino acid and catecholamine levels. Am. Rev. Respir. Dis. 141: 902-908.
3. Engelen, M. P., Wouters, E. F., Deutz, N. E., Menheere, P. P. & Schols, A. M. (2000) Factors contributing to alterations in skeletal muscle and plasma amino acid profiles in patients with chronic obstructive pulmonary disease. Am. J. Clin. Nutr. 72: 1480-1487.
4. Engelen, M. P., Wouters, E. F., Deutz, N. E., Does, J. D. & Schols, A. M. (2001) Effects of exercise on amino acid metabolism in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 163: 859-864.
5. Pouw, E. M., Schols, A.M.W.J., Deutz, N.E.P. & Wouters, E.F.M. (1998) Plasma and muscle amino-acid levels in relation to resting energy expenditure and inflammation in stable COPD. Am. J. Respir. Crit. Care Med. 158: 797-801.
6. Hack, V., Stutz, O., Kinscherf, R., Schykowski, M., Kellerer, M., Holm, E. & Droge, W. (1996) Elevated venous glutamate levels in (pre)catabolic conditions result at least partly from a decreased glutamate transport activity. J. Mol. Med. 74: 337-343.
7. Matthews, D. E., Marano, M. A. & Campbell, R. G. (1993) Splanchnic bed utilization of glutamine and glutamic acid in humans. Am. J. Physiol. 264: E848-E854.
8. Fernstrom, J. D. (2000) Pituitary hormone secretion in normal male humans: acute responses to a large, oral dose of monosodium glutamate. J. Nutr. 130: 1053S-1057S.
9. Fabbri, L. M. & Hurd, S. S. (2003) Global strategy for the diagnosis, management and prevention of COPD: 2003 update. Eur. Respir. J. 22: 1-2.
10. Clausen, J. L., Coates, A. L. & Quanjer, P. H. (1997) Measurement of lung volumes in humans: review and recommendations from an ATS/ERS workshop. Eur. Respir. J. 10: 1205-1206.
11. Steiner, M. C., Barton, R. L., Singh, S. J. & Morgan, M. D. (2002) Bedside methods versus dual energy X-ray absorptiometry for body composition measurement in COPD. Eur. Respir. J. 19: 626-631.
12. Kyle, U. G., Bosaeus, I., De Lorenzo, A. D., Deurenberg, P., Elia, M., Gomez, J. M., Heitmann, B. L., Kent-Smith, L., Melchior, J. C., Pirlich, M., Scharfetter, H., Schols, A. M. & Pichard, C. (2004) Bioelectrical impedance analysis-part I: review of principles and methods. Clin. Nutr. 23: 1226-1243.
13. Abumrad, N. N., Rabin, D., Diamond, M. P. & Lacy, W. W. (1981) Use of a heated superficial hand vein as an alternative site for the measurement of amino acid concentrations and for the study of glucose and alanine kinetics in man. Metabolism 30: 936-940.
14. Darmaun, D., Manary, M. J. & Matthews, D. E. (1985) A method for measuring both glutamine and glutamate levels and stable isotopic enrichments. Anal. Biochem. 147: 92-102.
15. Van Eijk, H. M., van der Heijden, M. A., van Berlo, C. L. & Soeters, P. B. (1988) Fully automated liquid-chromatographic determination of amino acids. Clin. Chem. 34: 2510-2513.
16. Van Eijk, H. M., Rooyakkers, D. R., Soeters, P. B. & Deutz, N. E. (1999) Determination of amino acid isotope enrichment using liquid chromatography-mass spectrometry. Anal Biochem. 271: 8-17.
17. Darmaun, D., Matthews, D. E. & Bier, D. M. (1986) Glutamine and glutamate kinetics in humans. Am. J. Physiol. 251: E117-E126.
18. Boirie, Y., Gachon, P. & Beaufrere, B. (1997) Splanchnic and whole-body leucine kinetics in young and elderly men. Am. J. Clin. Nutr. 65: 489-495.
19. Matthews, D. E. & Campbell, R. G. (1992) The effect of dietary protein intake on glutamine and glutamate nitrogen metabolism in humans. Am. J. Clin. Nutr. 55: 963-970.
20. Volpi, E., Mittendorfer, B., Wolf, S. E. & Wolfe, R. R. (1999) Oral amino acids stimulate muscle protein anabolism in the elderly despite higher first-pass splanchnic extraction. Am. J. Physiol. 277: E513-E520.
21. Boirie, Y., Gachon, P., Corny, S., Fauquant, J., Maubois, J. L. & Beaufrere, B. (1996) Acute postprandial changes in leucine metabolism as assessed with an intrinsically labeled milk protein. Am. J. Physiol. 271: E1083-E1091.
22. Wagenmakers, A. J. (1998) Protein and amino acid metabolism in human muscle. Adv. Exp. Med. Biol. 441: 307-319.
23. Engelen, M.P.K.J., Schols, A.M.W.J., Does, J. D., Gosker, H. R., Deutz, N.E.P. & Wouters, E.F.M. (2000) Exercise induced lactate increase in relation to muscle substrates in patients with COPD. Am. J. Respir. Crit. Care Med. 162: 1697-1704.