Noninsulinoma pancreatogenous hypoglycemia syndrome: A rare case of adult-onset nesidioblastosis

Internal Medicine

Volumn 44, Issue 8, 2005, Pages 843-847

  Tsujino, Motoyoshi ^a   Sugiyama, Toru ^a   Nishida, Kenji ^a   Takada, Yukari ^a   Takanishi, Kijuro ^a   Ishizawa, Mitugu ^a   Hirata, Yukio ^b  

^a TOKYO METROPOLITAN TAMA MEDICAL CENTER   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Hyperinsulinemic hypoglycemia; Nesidioblastosis; Noninsulinoma pancreatogenous hypoglycemia syndrome (NPHS); Selective arterial calcium injection (SACI)

Indexed keywords

CALCIUM; GLUCOSE; INSULIN;

AGED; ARTICLE; CASE REPORT; CELIAC ANGIOGRAPHY; COMPUTER ASSISTED TOMOGRAPHY; DIAGNOSTIC PROCEDURE; DIAGNOSTIC TEST; DIAGNOSTIC VALUE; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPERHIDROSIS; HYPOGLYCEMIC COMA; IMMUNOHISTOCHEMISTRY; INSULIN BLOOD LEVEL; INSULINOMA; MALE; NONINSULINOMA PANCREATOGENOUS HYPOGLYCEMIA SYNDROME; ONSET AGE; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET CELL HYPERPLASIA; PANCREAS RESECTION; TUMOR LOCALIZATION; TUMOR VOLUME;

AGE OF ONSET; AGED; CALCIUM GLUCONATE; GLUCAGON; HUMANS; HYPOGLYCEMIA; INSULIN; INSULINOMA; MALE; NESIDIOBLASTOSIS; PANCREATIC NEOPLASMS; SOMATOSTATIN; SYNDROME;

EID: 24644519944     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.44.843     Document Type: Article

References (18)

1. Brown RE, Young RB. A possible role for the exocrine pancreas in the pathogenesis of neonatal leucine-sensitive hypoglycemia. Am J Dig Dis 15: 65-72, 1970.
2. Thomas PM, Cote GJ, Wohlilk N, et al. Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy. Science 268: 426-429, 1995.
3. Nestorowicz A, Inagaki N, Gonoi T, et al. A nonsense mutation in the inward rectifier potassium channel gene, Kir6.2, is associated with familial hyperinsulinism. Diabetes 46: 1743-1748, 1997.
4. Perry RR, Vinik AI. Diagnosis and management of functioning islet cell tumors. J Clin Endocrinol Metab 80: 2273-2278, 1995.
5. Doppman JL, Chang R, Fraker DL, et al. Localization of insulinomas to regions of the pancreas by intraarterial stimulation by calcium. Ann Intern Med 123: 269-273, 1995 (Erratum in: Ann Intern Med 123: 734, 1995).
6. Service FJ, Natt N, Thompson GB, et al. Noninsulinoma pancreatogenous hypoglycemia: A novel syndrome of hyperinsulinemic hypoglycemia in adults independent of mutations in Kir6.2 and SUR1 genes. J Clin Endocrinol Metab 84: 1582-1589, 1999.
7. Thompson GB, Service FJ, Andrews JC, et al. Noninsulinoma pancreatogenous hypoglycemia syndrome: An update in 10 surgically treated patients. Surgery 128: 937-945, 2000.
8. Jabri AL, Bayard C. Nesidioblastosis associated with hyperinsulinemic hypoglycemia in adults: review of the literature. Eur J Intern Med 15: 407-410, 2004.
9. Harness JK, Geelhoed GW, Thompson NW, et al. Nesidioblastosis in adults. A surgical dilemma. Arch Surg 116: 575-580, 1981.
10. de Lonlay-Debeney P, Poggi-Travert F, Fournet JC, et al. Clinical features of 52 neonates with hyperinsulinism. N Engl J Med 340: 1169-1175, 1999.
11. Shultz KT, Neelon FA, Nilsen LB, Lebovitz HE. Mechanism of postgastrectomy hypoglycemia. Arch Intern Med 128: 240-246, 1971.
12. Marks V, Rose FC. Hypoglycemia. 2nd ed. Blackwell, Oxford, 1981.
13. Karnauchow PN. Nesidioblastosis in adults without insular hyperfunction. Am J Clin Pathol 78: 511-513, 1982.
14. Goudswaard WB, Houthoff HJ, Koudstaal J, Zwierstra RP. Nesidioblastosis and endocrine hyperplasia of the pancreas: a secondary phenomenon. Hum Pathol 17: 46-54, 1986.
15. Walmsley D, Matheson NA, Ewen S, Himsworth RL, Bevan JS. Nesidioblastosis in an elderly patient. Diabet Med 12: 542-545, 1995.
16. Lu JY, Huang TS, Wu MZ. Hypopituitarism and nesidioblastosis in an elderly patient with orbital lymphoma. J Formos Med Assoc 101: 68-72, 2002.
17. Mozell EJ, Woltering EA, O'Dorisio TM, et al. Adult onset nesidioblastosis: response of glucose, insulin, and secondary peptides to therapy with Sandostatin. Am J Gastroenterol 85: 181-188, 1990.
18. Martinez Valls JF, Ascaso JF, Ferrandez A, Hernandez A, Gonzalez Bayo E, Carmena R. Hyperplasia of the pancreatic islets or nesidioblastosis in adults? Apropos 2 cases. Med Clin (Barc) 95: 341-343, 1990 (in Spanish).