Pharmacologic cerebral capillary blood flow improvement after deep hypothermic circulatory arrest: An intravital fluorescence microscopy study in pigs

Journal of Thoracic and Cardiovascular Surgery

Volumn 130, Issue 3, 2005, Pages 670-676

  Mime, Lotfi Ben ^a   Arnhold, Stefan ^a   Fischer, Juergen Hartmut ^a   Addicks, Klaus ^a   De Vivie, Ernst Rainer ^a   Bennink, Gerardus ^a   Suedkamp, Michael ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EPTIFIBATIDE; FIBRINOGEN RECEPTOR ANTAGONIST; HEPARIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD FLOW VELOCITY; BRAIN CAPILLARY; BRAIN ISCHEMIA; BRAIN PERFUSION; BRAIN TISSUE; CAPILLARY DENSITY; CAPILLARY FLOW; CAPILLARY PERMEABILITY; CARDIOPULMONARY BYPASS; CELL DAMAGE; CELL ULTRASTRUCTURE; CLINICAL EXAMINATION; CONTROLLED STUDY; DENSITY FUNCTIONAL THEORY; EDEMA; ENDOTHELIUM CELL; ERYTHROCYTE; FLUORESCENCE MICROSCOPY; GENERAL CONDITION IMPROVEMENT; HEART ARREST; HIPPOCAMPUS; HISTOLOGY; MEDICAL DOCUMENTATION; MICROVASCULARIZATION; NONHUMAN; PIA ARTERY; PRIORITY JOURNAL; PROFOUND INDUCED HYPOTHERMIA; REPERFUSION INJURY; STATISTICAL SIGNIFICANCE; SWINE; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION; TISSUE OXYGENATION; WARMING;

ANIMALS; BLOOD FLOW VELOCITY; BRAIN; BRAIN ISCHEMIA; CAPILLARIES; CAPILLARY PERMEABILITY; CARDIOPULMONARY BYPASS; CEREBROVASCULAR CIRCULATION; HEART ARREST, INDUCED; HIPPOCAMPUS; HYPOTHERMIA, INDUCED; MICROCIRCULATION; MICROSCOPY, FLUORESCENCE; OXYGEN; PEPTIDES; PLATELET AGGREGATION INHIBITORS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; REPERFUSION; SWINE;

EID: 24644517175     PISSN: 00225223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jtcvs.2005.03.035     Document Type: Article

References (17)

1. S. Liu, J. Connor, S. Peterson, C.W. Shuttleworth, K.J. Liu Direct visualization of trapped erythrocytes in rat brain after focal ischemia and reperfusion J Cereb Blood Flow Metab. 22 2002 1222 1230
2. G.J. Del Zoppo, T. Mabuchi Cerebral microvessel responses to focal ischemia J Cereb Blood Flow Metab. 23 2003 879 894
3. A. Gunther, A. Manaenko, H. Franke, A. Wagner, D. Schneider, J. Berrouschot Hyperbaric and normobaric reoxygenation of hypoxic rat brain slices-impact on purine nucleotides and cell viability Neurochem Int. 45 2004 1125 1132
4. M.N. Ames, A. Senning Studies in oxygen consumption during extracorporeal circulation with a pump-oxygenator Ann Surg. 148 1958 59 65
5. W.I. Norwood, C.R. Norwood, A.R. Castaneda Cerebral anoxia effect of deep hypothermia and pH Surgery. 86 1979 203 209
6. S. Kourembanas, P.A. Marsden, L.P. McQuillan, D.V. Faller hypoxia induces endothelin gene expression and secretion in cultured human endothelium J Clin Invest. 88 1991 1054 1057
7. J.P. Gerler, V.H. Ocasio Endothelin production by hypoxic human endothelium J Vasc Surg. 18 1993 178 182 discussion 182-4.
8. Z.M. Ruggeri Platelet and von Willebrand factor interactions at the vessel wall Haemostaseologie. 24 2004 1 11
9. J.N. Cunningham, P.X. Adams, E.A. Knopp, F.G. Baumann, S.L. Snively, R.I. Gross Preservation of ATP, ultrastructure and ventricular function following aortic cross-clamping and reperfusion clinical use of blood potassium cardioplegia J Thorac Cardiovasc Surg. 78 1979 708 720
10. T. Heitzer, I. Ollmann, K. Koeke, T. Meinertz, T. Munzel Platelet glycoprotein IIb/IIIa receptor blockade improves vascular nitric oxide bioavailability in patients with coronary artery disease Circulation. 108 2003 536 541
11. L.F. Duebener, I. Hagino, T. Sakamoto, L. Ben Mime, C. Stamm, D. Zurakowski Effects of pH management during deep hypothermic bypass on cerebral microcirculation alpha-stat versus pH-stat Circulation. 106 suppl I 2002 I103 I108
12. Z.M. Ruggeri Platelets in atherothrombosis Nat Med. 8 2002 1227 1234
13. R.A. Cohen, J.T. Shepherd, P.M. Vanhoutte Inhibitory role of the endothelium in the response of isolated coronary arteries to platelets Science. 221 1983 273 274
14. D.S. Houston, J.T. Shepherd, P.M. Vanhoutte Aggregating human platelets cause direct contraction and endothelium-dependent relaxation of isolated canine coronary arteries role of serotonin, thromboxane A2, and adenine nucleotides J Clin Invest. 78 1986 539 544
15. Q. Pu, E. Wiel, D. Corseaux, R. Bordet, M.A. Azrin, M.D. Ezekowitz Beneficial effect of glycoprotein IIb/IIIa inhibitor (AZ-1) on endothelium in Escherichia coli endotoxin-induced shock Crit Care Med. 29 2001 1181 1188
16. R.E. Banks, M.A. Forbes, S.E. Kinsey, A. Stanley, E. Ingham, C. Walters Release of the angiogenic cytokine vascular endothelial growth factor (VEGF) from platelets significance for VEGF measurements and cancer biology Br J Cancer. 77 1998 956 964
17. B. Masson-Gadais, F. Houle, J. Laferriere, J. Huot Integrin alphavbeta3, requirement for VEGFR2-mediated activation of SAPK2/p38 and for Hsp90-dependent phosphorylation of focal adhesion kinase in endothelial cells activated by VEGF Cell Stress Chaperones. 8 2003 37 52