Policosanol, an aliphatic alcohol sugarcane derivative: Use in patients intolerant of or inadequately responsive to statin therapy

International Journal of Angiology

Volumn 13, Issue 4, 2004, Pages 173-175

  Wright, Christopher M ^a   Zielke, Judy C ^a   Whayne Jr , Thomas F ^a,b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DERIVATIVE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; POLICOSANOL;

ADULT; AGED; ARTICLE; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; DIET RESTRICTION; DRUG EFFICACY; DRUG SCREENING; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; LIPID ANALYSIS; MALE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; STATISTICAL ANALYSIS;

EID: 24644517051     PISSN: 10611711     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00547-005-2002-5     Document Type: Article

References (20)

1. I Gouni-Berthold HK Berthold 2002 Policosanol: Clinical pharmacology and therapeutic significance of a new lipid-lowering agent Am Heart J 143 356 365
2. SM Jamal MJ Eisenberg S Christopoulos 2004 Rhabdomyolysis associated with hydroxymethylglutaryl-coenzyme A reductase inhibitors Am Heart J 147 956 965
3. F Hernandez J Illnait R Mas 1992 Effect of policosanol on serum lipids and lipoproteins in healthy volunteers Curr Ther Res 51 568 575
4. E Aneiros B Calderon R Mas 1993 Effect of successive dose increases of policosanol on the lipid profile and tolerability of treatment Curr Ther Res 54 304 312
5. M Canetti M Moreira J Illnait 1995 One-year study of the effect of policosanol on lipid profile in patients with type II hypercholesterolemia Adv Ther 12 245 254
6. M Canetti M Moreira R Mas 1995 A two-year study on the efficacy and tolerability of policosanol in patients with type II hyperlipoproteinaemia Int J Clin Pharmacol Res 15 159 165
7. G Castano R Mas L Fernandez 2001 Effects of policosanol 20 versus 40 mg/day in the treatment of patients with type II hypercholesterolemia: a 6-month double blind study Int J Clin Pharmacol Res 21 43 57
8. R Alleva M Tomasetti M Battino 1995 The roles of coenzyme Q10 and vitamin E on the peroxidation of human low density lipoprotein subtractions Proc Natl Acad Sci USA 92 9388 9391
9. R Menendez SI Fernandez A Del Rio 1994 Policosanol inhibits cholesterol biosynthesis and enhances low density lipoprotein processing in cultured human fibroblasts Biol Res 27 199 203
10. R Menendez AM Amor RM Gonzalez 1996 Effect of policosanol on the hepatic cholesterol biosynthesis in normocholesterolemic rats Biol Res 29 253 257
11. R Menendez L Arruzazabala R Mas 1997 Cholesterol lowering effects of policosanol on rabbits with hypercholesterolaemia by a wheat starch-casein diet Br J Nutr 77 923 932
12. M Noa R Mas MC de la Rosa J Magraner 1995 Effect of policosanol on lipofundin-induced atheroscelerotic lesions in rats J Pharm Pharmacol 47 289 291
13. M Noa MC de la Rosa R Mas 1996 Effect of policosanol on foam cell formation in carrageenan-induced granulomas in rats J Pharm Pharmacol 48 306 309
14. M Noa R Mas R Mesa 1998 Effect of policosanol on intimal thickening in rabbit cuffed carotid artery Int J Cardiol 67 125 132
15. V Fraga R Menedez AM Amor 1997 Effect of policosanol on in vivo and in vitro rat liver microsomal lipid peroxidation Arch Med Res 28 355 360
16. R Menendez R Mas AM Amor 2000 Effects of policosanol treatment on the susceptibility of low density lipoprotein (LDL) isolated from healthy volunteers to oxidative modification in vitro Br J Clin Pharmacol 50 255 262
17. ML Arruzazabala D Carbajal R Mas 1993 Effects of policosanol on platelet aggregation in rats Thromb Res 69 321 327
18. 2 Prostaglandins Leukot Essent Fatty Acids 49 695 697
19. D Carbajal ML Arruzazabala R Mas 1994 Effect of policosanol on experimental thrombosis models Prostaglandins Leukot Essent Fatty Acids 50 249 251
20. ML Arruzazabala S Valdes R Mas 1997 Comparative study of policosanol, aspirin and the combination of policosanol-aspirin on platelet aggregation in healthy volunteers Pharmacol Res 36 293 297