Renal evaluation in the healthy green iguana (Iguana iguana): Assessment of plasma biochemistry, glomerular filtration rate, and endoscopic biopsy

Journal of Zoo and Wildlife Medicine

Volumn 36, Issue 2, 2005, Pages 155-168

  Hernandez Divers, Stephen J ^a   Stahl, Scott J ^b   Stedman, Nancy L ^a   Hernandez Divers, Sonia M ^a   Schumacher, Juergen ^c   Hanley, Christopher S ^a,e   Wilson, Heather ^a   Vidyashankar, Anand N ^a   Zhao, Ying ^a   Rumbeiha, Wilson K ^d  

^a UNIVERSITY OF GEORGIA   (United States)

^b Stahl Exotic Animal Veterinary Services   (United States)

^c UNIVERSITY OF TENNESSEE   (United States)

^d MICHIGAN STATE UNIVERSITY   (United States)

^e UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Endoscopy; Glomerular filtration rate; Green iguana; Iguana iguana; Iohexol; Kidney

Indexed keywords

ANIMALIA; IGUANA IGUANA; SQUAMATA;

EID: 24644507788     PISSN: 10427260     EISSN: None     Source Type: Journal    
DOI: 10.1638/03-120.1     Document Type: Article

References (68)

1. Albrechtsson, U., B. Hultberg, H. Larusdottir, and L. Norgren. 1985. Nephrotoxicity of ionic and non-ionic contrast media in aorto-femoral angiography. Acta Radiol. Diagn. 26: 615-618.
2. - in the lizard colon. Comp. Biochem. Physiol. A. 87: 883-887.
3. Benson, K. G., J. Paul-Murphy, and P. MacWilliams. 1999. Effects of hemolysis on plasma electrolyte and chemistry values in the common green iguana (Iguana iguana). J. Zoo Wildl. Med. 30: 413-415.
4. Bianchi, C., C. Donadio, and G. Tramonti. 1981. Noninvasive methods for the measurement of total renal function. Nephron 28: 53-57.
5. Bordley, J., and A. N. Richards. 1933. Quantitative studies of the composition of glomerular urine. VII. The concentration of uric acid in glomerular urine of snakes and frogs, determined by an ultramicroadaption of Folin's method. J. Biol. Chem. 101: 193-221.
6. Boyer, T. H., D. Getzy, L. Vap, and C. Innis. 1996. Clinicopathologic findings of twelve cases of renal failure in Iguana iguana. Proc. Annu. Conf. Assoc. Rept. Amph. Vet. Tampa, Florida. 113.
7. Bradshaw, S. D., and F. J. Bradshaw. 2002. Arginine vasotocin: site and mode of action in the reptilian kidney. Gen. Comp. Endocrinol. 126: 7-13.
8. Brown, S. A., D. R. Finco, F. D. Boudinot, J. Wright, S. L. Taver, and T. Cooper. 1996. Evaluation of a single injection method, using iohexol, for estimating glomerular filtration rate in cats and dogs. Am. J. Vet. Res. 57: 105-110.
9. Buck, A. C., M. A. Macleod, and N. J. Blacklock. 1980. The advantages of 99mTc DTPA(Sn) in dynamic renal scintigraphy and measurement of renal function. Br. J. Urol. 52: 174-186.
10. Chachati, A., A. Meyers, J. P. Godon, and P. Rigo. 1987. Rapid method for the measurement of differential renal function: validation. J. Nucl. Med. 28: 829-836.
11. Cole, B. R., J. Giangiacomo, J. R. Ingelfinger, and A. M. Robson. 1972. Measurement of renal function without urine collection. A critical evaluation of the constant-infusion technique for determination of inulin and para-aminohippurate. N. Engl. J. Med. 287: 1109-1114.
12. Dantzler, W. H. 1976. Renal function (with special emphasis on nitrogen excretion). In: Gans, C., and W.R. Dawson (eds.). Biology of the Reptilia, Physiology A Volume 5, Academic Press, London. Pp. 447-503.
13. Dantzler, W. H., and B. Schmidt-Nielson. 1966. Excretion in fresh-water (Pseudemys scripts) and the desert tortoise (Gopherus agassizii). Am. J. Physiol. 210: 198-210.
14. Davies, P. M. C. 1981. Anatomy and physiology. In: Cooper, J. E., and O. F. Jackson (eds.). Diseases of the Reptilia. Academic Press, London, U.K. Pp. 9-73.
15. Davis, L. E., B. Schmidt-Nielson, and H. Stolte. 1976. Anatomy and ultrastructure of the excretory system of the lizard, Sceloporus cyanogenys. J. Morphol. 149: 279-326.
16. Dencausse, A., C. Chambon, X. Violas, and B. Bonnemain. 1995. Comparative study of the dialysability of iobitridol and iohexol in the rat with impaired renal function. Acta Radiol. 36: 545-548.
17. Dennis, P. M., R. A. Bennett, K. E. Harr, and B. A. Lock. 2001. Plasma concentration of ionized calcium in healthy iguanas. J. Am. Vet. Med. Assoc. 219: 326-328.
18. Divers, S. J. 1995. The green iguana (Iguana iguana): a guide to successful captive management. Br. Herp. Soc. Bull. 51: 7-26.
19. Divers, S. J. 1997. A clinician's approach to renal disease in lizards. Proc. Annu. Conf. Assoc. Rept. Amph. Vet. Houston, Texas. 5-11.
20. Divers, S. J. 1999. Lizard endoscopic techniques with particular regard to the green iguana (Iguana iguana). Semin. Avian Exotic Pet Med. 8: 122-129.
21. Divers, S. J. 2000. Reptilian renal and reproductive disease diagnosis. In: Fudge, A. M. (ed.). Laboratory Medicine Avian and Exotic Pets. W. B. Saunders Co., Philadelphia, Pennsylvania. Pp. 217-222.
22. Divers, S. J., G. Redmayne, and E. K. Aves. 1996. Haematological and biochemical values of 10 green iguanas (Iguana iguana). Vet. Rec. 138: 203-205.
23. Donadio, C., G. Tramonti, R. Giordani, A. Lucchetti, A. Calderazzi, L. Bassani, and C. Bianchi. 1990. Effects on renal hemodynamics and tubular function of the contrast medium iohexol in renal patients. Renal. Fail. 12: 141-146.
24. Effersoe, H., P. Rosenkilde, S. Groth, L. I. Jensen, and K. Golman. 1990. Measurement of renal function with iohexol. A comparison of iohexol, 99mTc-DTPA, and 51Cr-EDTA clearance. Investig. Radiol. 25: 778-782.
25. Ehrenspeck, G., and C. Voner. 1985. Effect of furosemide on ion transport in the turtle bladder: evidence for direct inhibition of active acid-base transport. Biochem. Biophys. Acta. 817: 318-326.
26. Elder, G. 2002. Pathophysiology and recent advances in the management of renal osteodystrophy. J. Bone Miner. Res. 17: 2094-2105.
27. Finco, D. R., W. E. Braselton, and T. A. Cooper. 2001. Relationship between plasma iohexol clearance and urinary exogenous creatinine clearance in dogs. J. Vet. Intern. Med. 15: 368-373.
28. Fox, M., V. Natarajan, and N. C. Trippodo. 1993. Measurement, of cardiovascular and renal function in unrestrained hamsters. Lab. Anim. Sci. 43: 94-98.
29. Frennby, B., G. Sterner, T. Almen, C. M. Chai, B. A. Jonsson, and S. Mansson. 1996. Clearance of iohexol, chromium-51-ethylenediaminetetraacetic acid, and creatinine for determining the glomerular filtration rate in pigs with normal renal function: comparison of different clearance techniques. Acad. Radiol. 3: 651-659.
30. Frennby, B., G. Sterner, T. Almen, C. M. Chai, B. A. Jonsson, and S. Mansson. 1997. Clearance of iohexol, 51Cr-EDTA and endogenous creatinine for determination of glomerular filtration rate in pigs with reduced renal function: a comparison between different clearance techniques. Scand. J. Clin. Lab. Investig. 57: 241-252.
31. Frennby, B., G. Sterner, T. Almen, K. E. Hagstam, B. Hultberg, and L. Jacobsson. 1995. The use of iohexol clearance to determine GFR in patients with severe chronic renal failure - a comparison between different clearance techniques. Clin. Nephrol. 43: 35-46.
32. Gault, M. H., and J. B. Dossetor. 1968. The place of phenosulfonphthalein (PSP) in the measurement of renal function. Am. Heart J. 75: 723-727.
33. Gleadhill, A., and A. R. Michell. 1996. Evaluation of iohexol as a marker for the clinical measurement of glomerular filtration rate in dogs. Res. Vet. Sci. 60: 117-121.
34. Green, B. 1972. Aspects of renal function in the lizard, Varanus gouldii. Comp. Biochem. Physiol. 42: 747-756.
35. Guo, M., H. Ditrich, and H. Splechtna. 1996. Renal vasculature and uriniferous tubules in the common iguana. J. Morphol. 229: 97-104.
36. Harr, K. E., A. R. Alleman, P. M. Dennis, L. K. Maxwell, B. A. Lock, R. A. Bennett, and E. R. Jacobson. 2001. Morphologic and cytochemical characteristics of blood cells and hematologic and plasma biochemical reference ranges in green iguanas. J. Am. Vet. Med. Assoc. 218: 915-921.
37. Haughton, V. M. 1985. Intrathecal toxicity of iohexol vs. metrizamide. Survey and current state. Investig. Radiol. 20: 14-17.
38. Hernandez-Divers, S. J. 2003. Green iguana nephrology: a review of diagnostic techniques. Vet. Clin. North Am. Exotic Anim. Pract. 6: 233-250.
39. Hernandez-Divers, S. J., S. Stahl, S. M. Hernandez-Divers, M. R. Read, C. S. Hanley, F. Martinez, and T. L. Cooper. 2004. Coelomic endoscopy of the green iguana (Iguana iguana). J. Herp. Med. Surg. 14: 10-18.
40. Holz, P. H. 1999. The reptilian renal portal system - a review. Bull. Assoc. Rept. Amph. Vet. 9: 4-9.
41. Jacobson, E. 2003. Biology, Husbandry, and Medicine of the Green Iguana. Krieger Publishing Company. Malabar, Florida.
42. Kruger, J. M., W. E. Braselton, T. Becker, T. K. Graves, and K. J. Stuart. 1998. Putting GFR into practice: clinical applications of iohexol clearance. Proc. 16th Am. Coll. Vet. Intern. Med. Forum, San Diego, California. 657-658.
43. Levey, A. S. 1990. Measurement of renal function in chronic renal disease. Kidney Int. 38: 167-184.
44. Lora-Michiels, M., K. Anzola, G. Amaya, and M. Solano. 2001. Quantitative and qualitative scintigraphic measurement of renal function in dogs exposed to toxic doses of gentamicin. Vet. Radiol. Ultrasound 42: 553-561.
45. Lundqvist, S., G. Holmberg, G. Jakobsson, F. Lithner, K. Skinningsrud, B. Stegmayr, and S. O. Hietala. 1998. Assessment of possible nephrotoxicity from iohexol in patients with normal and impaired renal function. Acta Radiol. 39: 362-367.
46. Mader, D. R. 1998. A minimally invasive procedure for renal biopsies in the green iguana, Iguana iguana. Proc. Annu. Conf. Assoc. Rept. Amph. Vet. Kansas City, Missouri. 141.
47. Meints, R. H., F. J. Carver, J. W. Gerst, and D. W. McLaughlin. 1975. Erythropoietic activity in the turtle: the influence of hemolytic anemia, hypoxia and hemorrhage on hemopoietic function. Comp. Biochem. Physiol. A. 50: 419-422.
48. Moe, L., and R. Heiene. 1995. Estimation of glomerular filtration rate in dogs with 99M-Tc-DTPA and iohexol. Res. Vet. Sci. 58: 138-143.
49. Mutzel, W., H. M. Siefert, and U. Speck. 1980. Biochemical-pharmacologic properties of iohexol. Acta Radiol. 362(Suppl.): 111-115.
50. Nilsson-Ehle, P., and A. Grubb. 1994. New markers for the determination of GFR: iohexol clearance and cystatin C serum concentration. Kidney Int. 47(Suppl.): 17-19.
51. Nimmo, M. J., M. V. Merrick, and P. L. Allan. 1987. Measurement of relative renal function. A comparison of methods and assessment of reproducibility. Br. J. Radiol. 60: 861-864.
52. Nossen, J. O., J. A. Jakobsen, P. Kjaersgaard, E. Andrew, P. B. Jacobsen, and K. J. Berg. 1995. Elimination of the non-ionic X-ray contrast media iodixanol and iohexol in patients with severely impaired renal function. Scand. J. Clin. Lab. Investig. 55: 341-350.
53. Ranges, H. A., H. Chasis, W. Goldring, and H. W. Smith. 1939. The functional measurement of a number of active glomeruli and tubules in kidneys of normal and hypertensive subjects. Am. J. Physiol. 126: 103.
54. Roberts, J. S., and K. Schmidt-Nielson. 1969. Renal ultrastructure and excretion of salt and water by three terrestrial lizards. Am. J. Physiol. 211: 476-486.
55. Russell, C. D., and E. V. Dubovsky. 1989. Measurement of renal function with radionuclides. J. Nucl. Med. 30: 2053-2057.
56. Salvesen, S. 1980. Acute intravenous toxicity of iohexol in the mouse and in the rat. Acta Radiol. 362(Suppl.): 73-75.
57. Schmidt-Nielson, B., and L. E. Davies. 1968. Fluid transport and tubular intercellular spaces in reptilian kidneys. Science 159: 1105-1108.
58. Shihabi, Z. K., E. N. Thompson, and M. S. Constantinescu. 1993. Iohexol determination by direct injection of serum on the HPLC column. J. Liq. Chromatogr. 16: 1289-1296.
59. Shirley, D. G., S. J. Walter, and T. Zewde. 1989. Measurement of renal function in unrestrained conscious rats. J. Physiol. 408: 67-76.
60. Shoemaker, V. H., P. Licht, and W. R. Dawson. 1966. Effects of temperature on kidney function in the lizard Tillqua rugosa. Physiol. Zool. 39: 244-252.
61. Soares, A. M., and F. Fava-de-Morales. 1984. Morphological and morphometrical study of the kidney of the male tropical lizard Tropidurus torquatas. Anat. Anz. 157: 365-373. (German).
62. Stephens, G. A., and F. M. Robertson. 1985. Renal responses to diuretics in the turtle. J. Comp. Physiol. 155: 387-393.
63. Suedmeyer, K. 1995. Hypocalcemia and hyperphosphatemia in a green iguana, Iguana iguana, with concurrent elevation of serum glutamic oxalic transaminase. Bull. Assoc. Rept. Amph. Vet. 5: 5-6.
64. Templeton, J. R. 1964. Cardiovascular response to temperature in the lizard Sauromalus obesus. Physiol. Zool. 37: 300-306.
65. Thomsen, H. S., K. Golman, and O. Svendsen. 1991. Muscle toxicity of diatrizoate and iohexol in rabbits. A model for local tissue damage. Acta Radiol. 32: 182-183.
66. Toto, R. D. 1995. Conventional measurement of renal function utilizing serum creatinine, creatinine clearance, inulin and para-aminohippuric acid clearance. Curr. Opin. Nephrol. Hypertens. 4: 505-509.
67. Tsushima, Y., M. J. Blomley, S. Kusano, and K. Endo. 1999. Use of contrast-enhanced computed tomography to measure clearance per unit renal volume: a novel measurement of renal function and fractional vascular volume. Am. J. Kidney Dis. 33: 754-760.
68. Yamashita, M., T. Inaba, Y. Kawase, H. Horii, K. Wakita, R. Fujii, and H. Nakahashi. 1988. Quantitative measurement of renal function using Ga-68-EDTA. Tohoku J. Exp. Med. 155: 207-208.