Pathological assessment of pancreatic endocrine tumors for metastatic potential and clinical prognosis

Endocrine Pathology

Volumn 16, Issue 1, 2005, Pages 33-40

  Ohike, Nobuyuki ^a,b   Morohoshi, Toshio ^b  

^a SHOWA UNIVERSITY HOSPITAL   (Japan)

^b SHOWA UNIVERSITY   (Japan)

Author keywords

Differential diagnosis; Metastasis; Mixed exocrine endocrine carcinoma; Pancreatic endocrine tumor; Pathology; Prognosis

Indexed keywords

ALPHA FETOPROTEIN; BIOLOGICAL MARKER; CA 19-9 ANTIGEN; CARCINOEMBRYONIC ANTIGEN; KI 67 ANTIGEN; TRYPSIN;

ACINAR CELL CARCINOMA; ADULT; AGED; CANCER GROWTH; CANCER INVASION; CANCER RISK; CLINICAL ARTICLE; CONFERENCE PAPER; DISEASE COURSE; ENDOCRINE TUMOR; FEMALE; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LABELING INDEX; MALE; MALIGNANT NEOPLASTIC DISEASE; METASTASIS; MITOSIS INDEX; NECROSIS; PANCREAS TUMOR; PATHOLOGY; PRIORITY JOURNAL; PROGNOSIS; TUMOR CELL; TUMOR VOLUME;

EID: 24644503128     PISSN: 10463976     EISSN: None     Source Type: Journal    
DOI: 10.1385/ep:16:1:033     Document Type: Conference Paper

References (23)

1. Pelosi G, Bresaola E, Bogina G, et al. Endocrine tumors of the pancreas: Ki-67 immunoreactivity on paraffin sections is an independent predictor for malignancy: a comparative study with proliferating-cell nuclear antigen and progesterone receptor protein immunostaining, mitotic index, and other clinico-pathologic variables. Hum Pathol 27:1124-1134, 1996.
2. Clarke MR, Baker EE, Weyant RJ, Hill L, Carty SE. Proliferative activity in pancreatic endocrine tumors: association with function, metastases, and survival. Endocr Pathol 8:181-187, 1997.
3. Perret GA, Mosnier JF, Buono JP, et al. The relationship between MIB-1 proliferation index and outcome in pancreatic neuroendocrine tumors. Am J Clin Pathol 109:286-293, 1998.
4. Pelosi G, Zamboni G, Doglioni C, et al. Immunodetection of proliferating cell nuclear antigen assesses the growth fraction and predicts malignancy in endocrine tumors of the pancreas. Am J Surg Pathol 16:1215-1225, 1992.
5. Chang HJ, Batts KP, Lloyd RV, et al. Prognostic significance of p27, Ki-67, and topoisomerase lla expression in clinically nonfunctioning pancreatic endocrine tumors. Endocr Pathol 11:229-241, 2000.
6. Heitz PU, Kasper M, Klöppel G, Polak JM, Vaitukaitis JL. Glycoprotein-hormone alpha-chain production by pancreatic endocrine tumors: a specific marker for malignancy. Immunocytochemical analysis of tumors of 155 patients. Cancer 51:277-282, 1983.
7. Ohike N, Morohoshi T. Immunohistochemical analysis of cyclooxygenase (COX)-2 expression in pancreatic endocrine tumors: association with tumor progression and proliferation. Pathol Int 51:770-777, 2001.
8. Takumi Y, Ohike N. Pathomorphological study of angiogenesis in pancreatic endocrine tumors. Pancreas 29:2-3, 2004.
9. Viale G, Doglioni C, Gambacorta M, Zamboni G, Coggi G, Bordi C. Progesterone receptor immunoreactivity in pancreatic endocrine tumors. An immunocytochemical study of 156 neuroendocrine tumors of the pancreas, gastrointestinal and respiratory tracts, and skin. Cancer 70:2268-2277, 1992.
10. Speel EJ, Scheidweiler AF, Zhao J, et al. Genetic evidence for early divergence of small functioning and nonfunctioning endocrine pancreatic tumors: gain of 9Q34 is an early event in insulinomas. Cancer Res 61:5186-5192, 2001.
11. Solcia E, Capella C, Klöppel G: Tumors of the pancreas. In: Atlas of Tumor Pathology, 3rd Series, Fasc. 28. Armed Forces Institute of Pathology, Washington, DC, 1997.
12. Klöppel G, Heitz PU. Pancreatic endocrine tumors. Pathol Res Pract 183:155-168, 1988.
13. Klöppel G, Hruban RH, Longnecker DS, Adler G, Kern SE, Partanen TJ. Ductal adenocarcinoma of the pancreas. In: Hamilton SR, Aaltonen LA, eds. Pathology and genetics of tumours of the digestive system. WHO Classification of Tumours. IARC Press, Lyon, France, 2000.
14. Klöppel G. Mixed exocrine-endocrine tumors of the pancreas. Semin Diagn Pathol 17:104-108, 2000.
15. Klimstra DS, Rosai J, Heffess CS. Mixed acinar-endocrine carcinomas of the pancreas. Am J Surg Pathol 18:765-778, 1994.
16. Ohike N, Jurgensen A, Pipeleers-Marichal M, Klöppel G. Mixed ductal-endocrine carcinomas of the pancreas and ductal adenocarcinomas with scattered endocrine cells: characterization of the endocrine cells. Virchows Arch 442:258-265, 2003.
17. Ohike N, Kosmahl M, Klöppel G. Mixed acinar-endocrine carcinoma of the pancreas. A clinicopathological study and comparison with acinar-cell carcinoma. Virchows Arch 445:231-235, 2004.
18. Morohoshi T, Kanda M, Horie A, et al. Immunocytochemical markers of uncommon pancreatic tumors. Acinar cell carcinoma, pancreatoblastoma, and solid cystic (papillary-cystic) tumor. Cancer 59:739-747, 1987.
19. Solcia E, Klöppel G, Sobin LH. Endocrine tumours of the pancreas. In: Histological typing of endocrine tumours, 2nd ed. WHO International Histological Classification of Tumours. Heidelberg, Germany, 2000.
20. Hochwald SN, Zee S, Conlon KC, et al. Prognostic factors in pancreatic endocrine neoplasms: an analysis of 136 cases with a proposal for low-grade and intermediate-grade groups. J Clin Oncol 20:2633-2642, 2002.
21. Liu TH, Tseng HC, Zhu Y, Zhong SX, Chen J, Cui QC. Insulinoma. An immunocytochemical and morphologic analysis of 95 cases. Cancer 56:1420-1429, 1985.
22. Libutti SK, Choyke PL, Bartlett DL, et al. Pancreatic neuroendocrine tumors associated with von Hippel Lindau disease: diagnostic and management recommendations. Surgery 124:1153-1159, 1998.
23. Lam K, Lo C, Wat M, Fan ST. Malignant insulinoma with hepatoid differentiation: a unique case with alpha-fetoprotein production. Endocr Pathol 12:351-354, 2001.