William Spotnitz: Gifted scientist, inventory and cardiothoracic and vascular surgeon

Journal of Long-Term Effects of Medical Implants

Volumn 15, Issue 4, 2005, Pages 339-346

  Mintz, Paul D ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRIN; SEALANT; TISSUE ADHESIVE;

CORONARY ARTERY BYPASS GRAFT; ECHOCARDIOGRAPHY; HUMAN; INTRAOPERATIVE PERIOD; MEDICAL PROFESSION; MITRAL VALVE REGURGITATION; PATHOPHYSIOLOGY; REVIEW; SCIENCE; ART; ARTICLE; CARDIOLOGY; HISTORY; SURGERY; THORAX DISEASE; UNITED STATES; VASCULAR DISEASE;

CARDIOLOGY; ECHOCARDIOGRAPHY; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HUMANS; PORTRAITS; SURGERY; THORACIC DISEASES; UNITED STATES; VASCULAR DISEASES;

EID: 24644502637     PISSN: 10506934     EISSN: None     Source Type: Journal    
DOI: 10.1615/JLongTermEffMedImplants.v15.i4.10     Document Type: Review

References (69)

1. Sheil MLK, Kaul S, Spotnitz WD. Myocardial contrast echocardiography: development, applications, and future directions. Acad Radiol 1996; 3:260-75.
2. Spotnitz WD, Welker RL. Update on myocardial contrast echocardiography: a surgeons perspective. Semin Thorac Cardiovasc Surg 1998; 10:265-72.
3. Spotnitz WD, Matthew TL, Keller MW, Kaul S. Intraoperative myocardial contrast echocardiography. Dynamic Cardiovasc Imaging 1989; 2:157-66.
4. Jayaweera AR, Matthew TL, Sklenar J, Spotnitz WD, Watson DD, Kaul S. Method for the quantitation of myocardial perfusion during myocardial contrast two-dimensional echocardiography. J Am Soc Echocardiogr 1990; 3:91-8.
5. Matthew TL, Keller MW, Kaul S, Spotnitz WD. Assessment of myocardial perfusion during coronary artery bypass graft operations in humans using myocardial contrast echocardiography. Surg Forum 1989; 40:248-51.
6. Keller MW, Spotnitz WD, Matthew TL, Glasheen WP, Watson DD. Intraoperative assessment of regional myocardial perfusion using quantitative myocardial contrast echocardiography: an experimental evaluation. J Am Coll Cardiol 1990; 16:1267-79.
7. Spotnitz WD, Kaul S. Intraoperative assessment of myocardial perfusion using contrast echocardiography. Echocardiography 1990; 7:209-28.
8. Spotnitz WD, Oliner JD, Gascho JA, Nolan SP Kaul S. A new technique for myocardial contrast echocardiography in the experimental canine model using a special cannula for selective left main coronary artery cannulation. J Clin Ultrasound 1986; 14:742-5.
9. Spotnitz WD, Keller MW, Nolan SP, Kaul S. Success of internal mammary bypass grafting can be assessed intraoperatively using myocardial contrast echocardiography. J Am Coll Cardiol 1988; 12:196-201.
10. Spotnitz WD, Matthew TL, Keller MW, Powers ER, Kaul S. Intraoperative demonstration of coronary collateral flow using myocardial contrast two-dimensional echocardiography. Am J Cardiol 1990; 65:1259-61.
11. Villanueva F, Kaul S, Glasheen W, Broccoli A, Spotnitz WD. Intraoperative assessment of the distribution of retrograde cardioplegia using myocardial contrast echocardiography. Surg Forum 1990; 41:252-4.
12. Villanueva FS, Kaul S, Glasheen WP, Dent JM, Spotnitz WD. Discrepancy between capillary perfusion and myocardial cooling during retrograde cardioplegia: comparison with antegrade cardioplegia. Surg Forum 1992; 43:213-5.
13. Villanueva FS, Spotnitz WD, Glasheen WP, Watson DD, Jayaweera AR, Kaul S. New insights into the physiology of retrograde cardioplegia delivery. Am J Physiol 1995; 268:H1555-66.
14. Villanueva FS, Kaul S, Jayaweera AR, Sklenar J, Dent J, Gimple LW, Wyatt DA, Spotnitz WD. On-line quantitation of myocardial perfusion pre- and post-coronary artery bypass grafting using intraoperative myocardial contrast echocardiography. Surg Forum 1991; 42:208-10.
15. Villanueva FS, Spotnitz WD, Jayaweera AR, Dent J, Gimple LW, Kaul S. On-line intraoperative quantitation of regional myocardial perfusion during coronary artery bypass graft operations with myocardial contrast two-dimensional echocardiography. J Thorac Cardiovasc Surg 1992; 104:1524-31.
16. Kaul S, Jayaweera AR, Sklenar J, Glasheen WP, Gutgesell HP, Spotnitz WD. Myocardial contrast echocardiography and the transmural distribution of flow: a critical appraisal during myocardial ischemia not associated with infarction. J Am Coll Cardiol 1992; 20:1005-16.
17. Keller MW, Geddes L, Spotnitz WD, Kaul S, Duling BR. Microcirculatory dysfunction following perfusion with hyperkalemic, hypothermic, cardioplegic solutions and blood reperfusion: effects of adenosine. Circulation 1991; 84:2485-94.
18. Bayfield MS, Lindner JR, Kaul S, Ismail S, Goodman NC, Zacour R, Sheil M, Spotnitz WD. Deoxygenated blood minimizes adherence of sonicated albumin microbubbles during cardioplegic arrest and after blood reperfusion: experimental and clinical observations using myocardial contrast echocardiography. J Thorac Cardiovasc Surg 1997; 113:1100-8.
19. Lindner JR, Ismail S, Skyba P, Kaul S, Spotnitz WD. Albumin microbubble persistence during myocardial contrast echocardiography is associated with microvascular endothelial glycocalyx damage. Circulation 1998; 98:2187-94.
20. Dent JM, Jayaweera AR, Glasheen WP, Nolan SP, Spotnitz WD, Villanueva FS, Kaul S. A mathematical model for the quantitation of mitral regurgitation: experimental validation in the canine model using contrast echocardiography. Circulation 1992; 86:553-52.
21. Kaul S, Spotnitz WD, Glasheen WP, Touchstone DA. Mechanism of ischemic mitral regurgitation: an experimental evaluation. Circulation 1991; 84:2167-80.
22. Dent JM, Spotnitz WD, Nolan SP, Jayaweera AR, Glasheen WP, Kaul S. The determinants of the extent of mitral leaflet excursion using quantitative two-dimensional echocardiography. Am J Physiol 1995; 269:H2100-8.
23. Dent JM, Spotnitz WD, Kaul S. Echocardiographic evaluation of the mechanisms of ischemic mitral regurgitation. Coron Artery Dis 1996; 7:188-195.
24. Spotnitz WD, Mintz PD, Avery N, Bithell TC, Kaul S, Nolan SP. Fibrin glue from stored human plasma: an inexpensive and efficient method for local blood bank preparation. Am Surg 1987; 53:460-2.
25. Valenzuela GA, Spotnitz WD, Stone DD. Pepsin fibrinolysis of fibrin glue. Surg Endosc 1989; 3:148-51.
26. Matthew TL, Spotnitz WD, Gonias SL, Abbott RD, Jane JA. Increasing the life span of fibrin sealant-a comparison of three antifibrinolytic agents. Surg Forum 1990; 41:504-6.
27. Pipan CM, Glasheen WP, Gonias SL, Jane JA, Spotnitz WD. The life span of intraperitoneal fibrin sealant: the effects of three antifibrinolytic agents. Surg Forum 1991; 42:519-21.
28. Pipan CM, Glasheen WP, Matthew TL, Gonias SL, Hwang L-J, Jane JA, Spotnitz WD. The effects of antifibrinolytic agents on the life span of fibrin sealant. J Surg Res 1992; 53:402-407.
29. Ismail S, Glasheen WP, Gonias SL, Jane JA, Spotnitz WD. Bovine fibrin sealant: the intraperitoneal life span of a new hemostatic agent. Surg Forum 1993; 44:572-4.
30. Sanders RP, Goodman NC, Amiss LR Jr, Pierce RA, Moore MM, Marx G, Morgan RF, Spotnitz WD. Effect of fibrinogen and thrombin concentrations on mastectomy seroma prevention. J Surg Res 1996; 61:65-70.
31. Marek CA, Amiss LR Jr, Morgan RF, Spotnitz WD, Drake DB. Acute thrombogenic effects of fibrin sealant on microvascular anastomoses in a rat model. Ann Plast Surg 1998; 41:415-9.
32. Drake DB, Faulkner BC, Amiss LR Jr, Spotnitz WD, Morgan RF. Thrombogenic effects of a nonthrombin-based fibrin sealant compared with thrombin-based fibrin sealant in microvenous anastomoses in a rat model. Ann Plast Surg 2000; 45:520-4.
33. Frost-Arner L, Spotnitz WD, Rodeheaver GT, Drake DB. Comparison of the thrombogenicity of internationally available fibrin sealants in an established microsurgical model. J Plastic Reconstruct Surg 2001; 108:1655-60.
34. Wang J, Neisley H, Moody D, Dobraz, J, Spotnitz WD, Rodeheaver G. Fibrin sealant delivery system increases the effectiveness of silver sulfadiazine. Surg Forum 1999; 50:624-6.
35. Schlosser RJ, Spotnitz WD, Rodeheaver G, Scheld WM, Iezzoni J, Gross CW. Effects of fibrin sealant-containing antibiotics in rabbit model of chronic sinusitis. Am J Rhinology 2000; 14:233-40.
36. Tholpady SS, Schlosser RJ, Spotnitz WD, Ogle RC, Lindsey WH. Repair of an osseous facial critical-size defect using augmented fibrin sealant. Laryngoscope 1999; 109:1585-88.
37. Baker JW, Spotnitz WD, Matthew TL, Fechner RE, Nolan SP. Mediastinal fibrin glue: hemostatic effect and tissue response in calves. Ann Thorac Surg 1989; 47:450-2.
38. Ishitani MB, McGahren ED, Sibley DA, Spotnitz WD, Rodgers BM. Laparoscopically applied fibrin glue in experimental liver trauma. J Pediatr Surg 1989; 24:867-71.
39. Ismail S, Combs, MJ, Goodman NC, Teotia SS, Teates CD, Abbott RD, Fechner RE, Nolan SP, Powers ER, Spotnitz WD. Reduction of femoral arterial bleeding post catheterization using percutaneous application of fibrin sealant. Cath Cardiovasc Diag 1995; 34:88-95.
40. Falstrom JK, Goodman NC, Ates G, Abbott RD, Powers ER, Spotnitz WD. Reduction of femoral artery bleeding post catheterization using a fibrin enhanced collagen sealant. Cath Cardiovasc Diag 1997; 41:79-84.
41. Curtin W, Wang G-J, Goodman N, Abbott R, Spotnitz W. Reduction of bleeding using cryo-based fibrin sealant in a canine anticoagulated knee arthroplasty model. Surg Forum 1997; 48:558-60.
42. Moore M, Burak W Jr, Nelson E, Kearney T, Simmons R, Mayers L, Spotnitz W. Fibrin sealant reduces the duration and amount of fluid drainage following axillary dissection: a randomized prospective clinical trial. J Am Coll Surg 2001; 192:591-9.
43. Falstrom JK, Moore MM, Caldwell SH, Matsumoto AH, Abbott RD, Spotnitz WD. Use of fibrin sealant to reduce bleeding after needle liver biopsy in an anticoagulated canine model: work in progress. J Vasc Interv Radiol 1999; 10:457-62.
44. Lindsey WH, Spotnitz WD, Llaneras MR, Masterson TM, Wanebo HJ, Morgan RF. Seroma prevention using fibrin glue during modified radical neck dissection in a rat model. Am J Surg 1988; 156:310-3.
45. Lindsey WH, Masterson T, Spotnitz WD, Wilhelm MC, Morgan RF. Seroma prevention using fibrin glue in a rat mastectomy model. Arch Surg 1990; 25:305-7.
46. Wang JY, Goodman NC, Amiss LR Jr, Nguyen DHD, Rodeheaver GT, Moore MM, Morgan RF, Abbott RD, Spotnitz WD. Seroma prevention in a rat mastectomy model: use of a light-activated fibrin sealant. Ann Plast Surg 1996; 7:400-5.
47. Moore M, Burak Jr. W, Nelson E, Kearney T, Simmons R, Buchanan S, Spotnitz W. Fibrin sealant reduces the amount and duration of fluid drainage after axillary lymphadenectomy. Surg Forum 1997; 48:866-7.
48. Baker JW, Spotnitz WD, Nolan SP. A technique for spray application of fibrin glue during cardiac operations. Ann Thorac Surg 1987; 43:564-5.
49. Spotnitz WD, Dalton MS, Baker JW, Nolan SP. Reduction of perioperative hemorrhage by anterior mediastinal spray application of fibrin glue during cardiac operations. Ann Thorac Surg 1987; 44:529-31.
50. Gross CW, Gallagher R, Schlosser RJ, Burks SG, Flanagan HL, Mintz PD, Avery NL, Mayers SL, Spotnitz WD. Application of single donor fibrin glue to burns. J Burn Care Rehab 1988; 9:619-22.
51. Schlosser RJ, Gallagher R, Burks SG, Flanagan HL, Mintz PD, Avery NL, Mayers SL, Spotnitz WD, Gross CW. Autologous fibrin sealant reduces pain following tonsillectomy. Laryngoscope 2001; 111:259-63.
52. Schenk W, Goldthwaite C Jr, Burks S, Spotnitz W. Fibrin sealant facilitates hemostasis in arteriovenous polytetrafluoroethylene grafts for renal dialysis access. Am Surg 2002; 68:728-32.
53. Schenk W, Burks S, Gagne P, Kagan S, Lawson J, Spotnitz W. Fibrin sealant improves hemostasis in peripheral vascular surgery: a randomized prospective trial. Ann Surgery 2003; 237:871-6.
54. Wang GJ, Hungerford DS, Savory CG, Rosenberg AG, Mont MA, Burks, SG, Mayers SL, Spotnitz WD. Use of fibrin sealant to reduce bloody drainage and hemoglobin loss after total knee arthroplasty. A brief note of a randomized prospective trial. J Bone Joint Surg 2001; 3-A:1503-5.
55. Wang GJ, Goldthwaite CA Jr, Burks SG, Spotnitz WD. Experience improves successful use of fibrin sealant in total knee arthroplasty: implications for surgical education. J Long Term Eff Med Implants 2003; 13:389-97.
56. Wang GJ, Goldthwaite CA Jr, Burks SG, Crawford R, Spotnitz WD. Fibrin sealant reduces perioperative blood loss in total hip replacement. J Long Term Eff Med Implants 2003; 13:399-411.
57. Moore MM, Nguyen DHD, Spotnitz WD. Fibrin sealant reduces serous drainage and allows earlier drain removal after axillary dissection: a randomized prospective trial. Am Surg 1997; 63:97-102.
58. Moore M, Burak W Jr, Nelson E, Kearney T, Simmons R, Mayers L, Spotnitz W. Fibrin sealant reduces the duration and amount of fluid drainage following axillary dissection: a randomized prospective clinical trial. J Am Coll Surg 2001; 192:591-9.
59. Glover W, Chavis TV, Daniel TM, Kron IL, Spotnitz WD. Fibrin glue application via the flexible fiberoptic bronchoscope: closure of bronchopleural fistulas. J Thorac Cardiovasc Surg 1987; 93:470-2.
60. O'Neill PJ, Flanagan HL, Mauney MC, Lantrip BS, Wallace KK, Spotnitz WD, Daniel TM. Intrathoracic catheter-directed fibrin sealant application using computed tomography fluoroscopy. Ann Thorac Surg 2000; 70:301-2.
61. Shaffrey, CI, Spotnitz WD, Shaffrey ME, Jane JA. Neurosurgical applications of fibrin glue: augmentation of dural closure in 134 patients. Neurosurgery 1990; 26:207-10.
62. Spotnitz WD, Dalton MS, Baker JW, Nolan SP. Successful use of fibrin glue during two years of surgery at a university medical center 1985-1987. Am Surg 1989; 55:166-8.
63. Matthew TL, Spotnitz WD, Kron IL, Daniel TM, Tribble CG, Nolan SP. Four years experience with fibrin sealant in thoracic and cardiovascular surgery. Ann Thorac Surg 1990; 50:40-4.
64. Spotnitz WD. Fibrin sealant in the United States: clinical use at the University of Virginia. Thromb Haemost 1995; 74:482-485.
65. Martinowitz U, Spotnitz WD. Fibrin tissue adhesives. Thromb Haemost 1997; 78:661-6.
66. Spotnitz WD. New developments in the use of fibrin sealant: a surgeon's perspective. J Long Term Eff Med Implants 1997; 7:243-53.
67. Spotnitz WD. Four years' experience with fibrin sealant in thoracic and cardiovascular surgery: an update. Ann Thorac Surg 1998; 65:592-3.
68. Mintz PD, Mayers L, Avery N, Flanagan HL, Burks SG, Spotnitz WD. Review: fibrin sealant: clinical use and the development of the University of Virginia Tissue Adhesive Center. Ann Clin Lab Sci 2001; 1:108-18.
69. Spotnitz WD. Commercial fibrin sealants in surgical care. Am J Surg 2001; 182:8S-14S.