Preoperative serum levels of the carcinoembryonic antigen in hereditary non-polyposis colorectal cancer compared to levels in sporadic colorectal cancer

Cancer Detection and Prevention

Volumn 29, Issue 4, 2005, Pages 356-360

  Schiemann, Uwe ^a,f   Günther, Silke ^a   Gross, Manfred ^e   Henke, Gaby ^b   Müller Koch, Yvonne ^b   König, August ^a   Muders, Michael ^c   Folwaczny, Christian ^d   Mussack, Thomas ^d   Holinski Feder, Elke ^b  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b Institut fur Humangenetik   (Germany)

^c Institut fur Pathologie   (Germany)

^d UNIVERSITY OF MUNICH   (Germany)

^e Internistische Klinik Dr Muller   (Germany)

^f UNIVERSITY OF BERN   (Switzerland)

Author keywords

Carcinoembryonic antigen (CEA); DNA extraction; Hereditary nonpolyposis colorectal cancer (HNPCC); Immunohistochemistry; Microsatellite instability (MSI); Mismatch repair gene; Mutation analysis

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; PROTEIN MLH1; PROTEIN MSH2;

ADULT; ARTICLE; BLOOD LEVEL; CANCER PATIENT; COLORECTAL CANCER; FEMALE; GENE MUTATION; HUMAN; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; MICROSATELLITE MARKER; MUTATIONAL ANALYSIS; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; STATISTICAL SIGNIFICANCE; TUMOR DIFFERENTIATION; VALIDATION PROCESS;

AGED; CARCINOEMBRYONIC ANTIGEN; CARRIER PROTEINS; COLORECTAL NEOPLASMS; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; FEMALE; GERM-LINE MUTATION; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; MUTS HOMOLOG 2 PROTEIN; NEOPLASM STAGING; NUCLEAR PROTEINS; POLYMERASE CHAIN REACTION; PREOPERATIVE CARE; SENSITIVITY AND SPECIFICITY; TUMOR MARKERS, BIOLOGICAL;

EID: 24644498223     PISSN: 0361090X     EISSN: 15251500     Source Type: Journal    
DOI: 10.1016/j.cdp.2005.04.003     Document Type: Article

References (28)

1. P. Gold, and S.O. Freeman Demonstration of tumor specific antigen in human colonic carcinomata by immunological tolerance and absorption techniques J Exp Med 121 1965 439 462
2. D.M.P. Thomson, J. Krupey, and S.O. Freedman The radioimmunoassay of circulating carcinoembryonic antigen of the human digestive tract Proc Natl Acad Sci USA 66 1966 161 167
3. M.A. Herrera, T.M. Chu, and E.D. Holyoke Carcinoembryonic antigen (CEA) as a prognostic and monitoring test in clinically complete resection of colorectal carcinoma Ann Surg 183 1976 5 9
4. H.J. Wanebo, B. Rao, and C.M. Pinsky Preoperative carcinoembryonic antigen level as a prognostic indicator in colorectal cancer N Engl J Med 299 1978 448 451
5. J.J. Szymendera, M.P. Nowacki, and A.W. Szawlowski Predictive value of plasma CEA levels: preoperative prognosis and postoperative monitoring of patients with colorectal carcinoma Dis Colon Rectum 25 1982 46 52
6. M. Diez, M. Pollan, and J.M. Muguerza Time-dependency of the prognostic effect of carcinoembryonic antigen and p53 protein in colorectal adenocarcinoma Cancer 88 2000 35 41
7. S. Wiratkapun, M. Kraemer, and F. Seow-Choen High preoperative serum carcinoembryonic antigen predict metastatic recurrence in potentially curative colonic cancer: results of a 5-year study Dis Colon Rectum 44 2001 231 235
8. B. Engaras, J. Kewenter, and O. Nilsson CEA, CA 50 and CA 242 in patients surviving colorectal cancer without recurrent disease Eur J Surg Oncol 27 2001 43 48
9. J. Marchena, M.A. Acosta, and F. Garcia-Anguiano Use of the preoperative levels of CEA in patients with colorectal cancer Hepatogastroenterology 50 2003 1017 1020
10. H.F.A. Vasen, J.P. Mecklin, and K.P. Meera The International Collaborative Group on hereditary non-polyposis colorectal cancer Dis Colon Rectum 34 1991 424 425
11. M.A. Rodriguez-Bigas, C.R. Boland, and S.R. Hamilton A National Cancer Institute workshop on hereditary nonpolyposis colorectal cancer syndrome: meeting highlights and Bethesda guidelines J Natl Cancer Inst 89 1997 1758 1762
12. C.E. Dukes, and H.J. Bussey The spread of rectal cancer and its effect on prognosis Br J Cancer 12 1958 309 320
13. J. Koreth, J. ÓLeary, and J. McGee Microsatellites and PCR genomic analysis J Pathol 178 1996 239 248
14. C.R. Boland, S.N. Thibodeau, and S.R. Hamilton A National Cancer Institute workshop on microsatellite instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer Cancer Res 58 1998 5248 5257
15. E. Holinski-Feder, Y. Müller-Koch, and W. Friedl DHPLC mutation analysis of the hereditary nonpolyposis colon cancer (HNPCC) genes hMLH1 and hMSH2 J Biochem Biophys Meth 47 2001 21 32
16. Y. Müller-Koch, R. Kopp, and P. Lohse Sixteen rare sequence variants of the hMLH1 and hMSH2 genes found in a cohort of 254 suspected HNPCC patients: mutations or polymorphism? Eur J Med Res 6 2001 473 482
17. U. Schiemann, Y. Müller-Koch, and M. Gross Extended microsatellite analysis in microsatellite stable, MSH2 and MLH1 mutation-negative HNPCC patients: genetic reclassification and correlation to clinical features Digestion 69 2004 166 176
18. M.J. Duffy Carcinomebryonic antigen as a marker for colorectal cancer: is it clinically useful? Clin Chem 47 2001 624 630
19. E. Bombardieri, G.S. Jotti, and M.G. Cocciolo Tissue polypeptide antigen and carcinoembryonic antigen in colon tumors: serum levels and immunohistochemical localization Cancer Detect Prev 8 1985 219 226
20. M. Carpelan-Holmstrom, J. Louhimo, and U.H. Stenman CEA, CA19-9, and CA 72-4 improve the diagnostic accuracy in gastrointestinal cancers Anticancer Res 22 2002 2311 2316
21. J.P. Arnaud, C. Koehl, and M. Adloff Carcinoembryonal antigen (CEA) in diagnosis and prognosis of colorectal carcinoma Dis Colon Rectum 23 1980 141 144
22. S. Wiratkapun, M. Kraemer, and F. Seow-Choen High preoperative serum carcinoembryonic antigen predicts metastatic recurrence in potentially curative colonic cancer: results of a 5-year study Dis Colon Rectum 44 2001 231 235
23. C.G. Moertel, J.R. ÓFallon, and V.L.W. Go The preoperative carcinoembryonic antigen test in the diagnosis, staging, and prognosis of colorectal cancer Cancer 58 1986 603 610
24. H. Sikorska, J. Shuster, and P. Gold Clinical applications of carcinoembryonic antigen Cancer Detect Prev 12 1988 321 355
25. J. Wijnen, P.M. Khan, and H. Vasen Hereditary nonpolyposis colorectal cancer families not complying with the Amsterdam criteria show extremely low frequency of mismatch-repair-gene mutations Am J Hum Genet 61 1997 329 335
26. S. Hammarström The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues Sem Cancer Biol 9 1999 67 81
27. S. Benchimol, A. Fuks, and S. Jothy Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule Cell 57 1989 327 334
28. S.B. Lim, S.Y. Jeong, and M.R. Lee Prognostic significance of microsatellite instability in sporadic colorectal cancer Int J Colorectal Dis 19 2004 533 537