Proinsulin: Much more than a hormone precursor in development

Reviews in Endocrine and Metabolic Disorders

Volumn 6, Issue 3, 2005, Pages 211-216

  Hernández Sánchez, Catalina ^a   Bártulos, Óscar ^a   De Pablo, Flora ^a  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

Author keywords

Alternative transcripts; Apoptosis; Early development; Proinsulin

Indexed keywords

HORMONE PRECURSOR; INSULIN RECEPTOR; MEMBRANE RECEPTOR; PROINSULIN; PROTEIN TYROSINE KINASE; SOMATOMEDIN; SOMATOMEDIN C;

CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; DEVELOPMENTAL STAGE; DOWN REGULATION; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; FOOD INTAKE; GENETIC TRANSCRIPTION; GLUCOSE HOMEOSTASIS; HORMONE RELEASE; HUMAN; MOLECULAR MECHANICS; NONHUMAN; ORGANOGENESIS; PHENOTYPE; POSTNATAL DEVELOPMENT; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; RNA TRANSLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION SITE;

ANIMALS; CHICK EMBRYO; EMBRYO; GENE EXPRESSION REGULATION, DEVELOPMENTAL; INSULIN; PROINSULIN; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION;

EID: 24644476475     PISSN: 13899155     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11154-005-3052-x     Document Type: Review

References (57)

1. De Pablo F, Roth J. Endocrinization of the early embryo: an emerging role for hormones and hormone-like factors. Trends Biochem Sci 1990;15:339-342.
2. De Pablo F, de la Rosa EJ. The developing CNS: a scenario for the action of proinsulin, insulin and insulin-like growth factors. Trends Neurosci 1995;18:143-150.
3. Varela-Nieto I, de la Rosa EJ, Valenciano AI, Leon Y. Cell death in the nervous system: lessons from insulin and insulin-like growth factors. Mol Neurobiol 2003;28:23-50.
4. Hernandez-Sanchez C, Rubio E, Serna J, de la Rosa EJ, De Pablo F. Unprocessed proinsulin promotes cell survival during neurulation in the chick embryo. Diabetes 2002;51:770-777.
5. Pierce SB, Costa M, Wisotzkey R, Devadhar S, Homburger SA, Buchman AR, Ferguson KC, Heller J, Platt DM, Pasquinelli AA, Liu LX, Doberstein SK, Ruvkun G. Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse Celegans insulin gene family. Genes Dev 2001;15:672-686.
6. Brogiolo W, Stocker H, Ikeya T, Rintelen F, Fernandez R, Hafen E. An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control. Curr Biol 2001;20(11):213-221.
7. De Pablo F, Girbau M, Gomez JA, Hernandez E, Roth J. Insulin antibodies retard and insulin accelerates growth and differentiation in early embryos. Diabetes 1985;34:1063-1067.
8. De Pablo F, Hernandez E, Collia F, Gomez JA. Untoward effects of pharmacological doses of insulin in early chick embryos. Through which receptor are they mediated? Diabetologia 1985;28:308-313.
9. Travers JP, Pratten MK, Beck F. Effects of low insulin levels on rat embryonic growth and development. Diabetes 1989;38:773-778.
10. Morales AV, Serna J, Alarcon C, de la Rosa EJ, De Pablo F. Role of prepancreatic (pro)insulin and the insulin receptor in prevention of embryonic apoptosis. Endocrinology 1997;138:3967-3975.
11. Patwardhan V, Gokhale M, Ghaskadbi S. Acceleration of early chick embryo morphogenesis by insulin is associated with altered expression of embryonic genes. Int J Dev Biol 2004;48:319-326.
12. Lough J, Sugi Y. Endoderm and heart development. Dev Dyn 2000;217:327-342.
13. Nakae J, Kido Y, Accili D. Distinct and overlapping functions of insulin and IGF-I receptors. EndocrRev 2001;22:818-835.
14. Hernandez-Sanchez C, Lopez-Carranza A, Alarcon C, de la Rosa EJ, De Pablo F. Autocrine/paracrine role of insulin-related growth factors in neurogenesis: Local expression and effects on cell proliferation and differentiation in retina. Proc Natl AcadSci USA 1995;92:9834-9838.
15. Hernandez-Sanchez C, Mansilla A, de la Rosa EJ, Pollerberg GE, Martinez-Salas E, De Pablo F. Upstream AUGs in embryonic proinsulin mRNA control its low translation level. EMBO J 2003;22:5582-5592.
16. Alarcon C, Sema J, Perez-Villamil B, De Pablo F. Synthesis and differentially regulated processing of proinsulin in developing chick pancreas, liver and neuroretina. FEES Lett 1998;436:361-366.
17. Garcia-de Lacoba M, Alarcon C, de la Rosa EJ, De Pablo F. Insulin/insulin-like growth factor-I hybrid receptors with high affinity for insulin are developmentally regulated during neurogenesis. Endocrinology 1999;140:233-243.
18. Soos MA, Field CE, Siddle K. Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity. Biochem J 1993;29Q:419-126.
19. Bailyes EM, Nave BT, Soos MA, Orr SR, Hayward AC, Siddle K. Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting. Biochem J 1997;327:209-215.
20. Diaz B, Serna J, De Pablo F, de la Rosa EJ. In vivo regulation of cell death by embryonic (pro)insulin and the insulin receptor during early retinal neurogenesis. Development 2000;127:1641-1649.
21. Serrano J, Bevins CL, Young SW, De Pablo F. Insulin gene expression in chicken ontogeny: pancreatic, extrapancreatic, and prepancreatic. Dev Biol 1989;132:410-418.
22. Shuldiner AR, De Pablo F, Moore CA, Roth J. Two nonallelic insulin genes in Xenopus laevis are expressed differentially during neurulation in prepancreatic embryos. Proc Natl Acad Sci USA 1991;88:7679-7683.
23. Deltour L, Leduque P, Blume N, Madsen O, Dubois P, Jami J, Bucchini D. Differential expression of the two nonallelic proinsulin genes in the developing mouse embryo. Proc Natl Acad Sci USA 1993;90:527-531.
24. Perez-Villamil B, de la Rosa EJ, Morales AV, De Pablo F. Developmentally regulated expression of the preproinsulin gene in the chicken embryo during gastrulation and neurulation. Endocrinology 1994;135:2342-2350.
25. Girbau M, Bassas L, Alemany J, De Pablo F. In situ autoradiography and ligand - dependent tyrosine kinase activity reveal insulin receptors and insulin-like growth factor I receptors in prepancreatic chicken embryos. Proc Natl Acad Sci USA 1989;86:5868-5872.
26. De la Rosa EJ, Bondy CA, Hernandez-Sanchez C, Wu X, Zhou J, Lopez-Carranza A, Scavo LM, De Pablo F. Insulin and insulin-like growth factor system components gene expression in the chicken retina from early neurogenesis until late development and their effect on neuroepithelial cells. Eur J Neurosci 1994;6:1801-1810.
27. Robbins DC, Tager HS, Rubenstein AH. Biologic and clinical importance of proinsulin. N Engl J Med 1984;310:1165-1175.
28. Rhodes CJ. Processing of the insulin molecule. In Le Roith D, Taylor SI, Olefsky JM eds. Diabetes Mellitus: A Fundamental and Clinical Text. Philadelphia, Lippincott Williams & Wilkins. USA, 2000:20-38.
29. Orci L. The insulin factory: a tour of the plant surroundings and a visit to the assembly line. The Minkowski lecture 1973 revisited. Diabetologia 1985;28:528-546.
30. Steiner DF, Bell GI, Tager HS. Chemistry and biosynthesis of pancreatic protein hormones. In De Groot LJ ed Endocrinology. Philadelphia, WB Saunders company, USA, 1990, 1263-1289.
31. Muglia L, Locker J. Extrapancreatic insulin gene expression in the fetal rat. Proc Natl Acad Sci USA 1984;81:3635-3639.
32. Kelly RB. Pathways of protein secretion in eukaryotes. Science 1985;230:25-32.
33. Lumelsky N, Blondel O, Laeng P, Velasco I, Ravin R, McKay R. Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science 2001;292:1389-1394.
34. Brunstedt J, Chan SJ. Direct effect of glucose on the preproinsulin mRNA level in isolated pancreatic islets. Biochem Biophys Res Commun 1982;106:1383-1389.
35. Nielsen DA, Welsh M, Casadaban MJ, Steiner DF. Control of insulin gene expression in pancreatic beta-cells and in an insulin-producing cell line, RIN-5F cells. I. Effects of glucose and cyclic AMP on the transcription of insulin mRNA. J Biol Chem 1985;260:13585-13589.
36. Welsh M, Nielsen DA, MacKrell AJ, Steiner DF. Control of insulin gene expression in pancreatic beta-cells and in an insulin-producing cell line, RIN-5F cells. II. Regulation of insulin mRNA stability. J Biol Chem 1985;260:13590-13594.
37. Leibiger B, Moede T, Schwarz T, Brown GR, Kohler M, Leibiger IB, Berggren PO. Short-term regulation of insulin gene transcription by glucose. Proc Natl Acad Sci USA 1998;95:9307-9312.
38. Permutt MA. Effect of glucose on initiation and elongation rates in isolated rat pancreatic islets. J Biol Chem 1974;249:2738-2742.
39. Itoh N, Okamoto H. Translational control of proinsulin synthesis by glucose. Nature 1980;283:100-102.
40. Welsh M, Scherberg N, Gilmore R, Steiner DF. Translational control of insulin biosynthesis. Evidence for regulation of elongation, initiation and signal-recognition- particle-mediated translational arrest by glucose. Biochem J 1986;235:459-167.
41. Giddings SJ, Carnaghi LR. Selective expression and developmental regulation of the ancestral rat insulin II gene in fetal liver. Mol Endocrinol 1990;4:1363-1369.
42. Morris DR, Geballe AP. Upstream open reading frames as regulators of mRNA translation. Mol Cell Biol 2000;20:8635-8642.
43. Geballe AP, Sachs MS. Translational Control by Upstream Open Reading Frames. In Sonenberg N, Hershey JW, Mathews MB eds., Translational Control of Gene Expression. New York, Cold Spring Harbor Laboratory Press, USA. 2000
44. Kozak M. Pushing the limits of the scanning mechanism for initiation of translation. Gene 2002;299:1-34.
45. Rosenfeld RG, Roberts CT (eds.), The IGF System. In Molecular Biology, Physiology, and Clinical Applications. Humana, Totowa, New Jersey, 1999
46. Pampfer S, Vanderheyden I, McCracken JE, Vesela J, De Hertogh R. Increased cell death in rat blastocysts exposed to maternal diabetes in utero and to high glucose or tumor necrosis factor-alpha in vitro. Development 1997;124:4827-4836.
47. Phelan SA, Ito M, Loeken MR. Neural tube defects in embryos of diabetic mice: Role of the Pax-3 gene and apoptosis. Diabetes 1997;46:1189-1197.
48. Moley KH, Chi MM, Knudson CM, Korsmeyer SJ, Mueckler MM. Hyperglycemia induces apoptosis in pre-implantation embryos through cell death effector pathways. Nat Med 1998;4:1421-1424.
49. Fine EL, Moral M, Chang TI, Fortin G, Loeken MR. Evidence that elevated glucose causes altered gene expression, apoptosis, and neural tube defects in a mouse model of diabetic pregnancy. Diabetes 1999;48:2454-2462.
50. Moley KM. Hyperglycemia and apoptosis: mechanisms for congenital malformations and pregnancy loss in diabetic women. Trends Endocrinol Metab 2001;12:78-82.
51. Kuida K, Zheng TS, Na S, Kuan C, Yang D, Karasuyama H, Rakic P, Flavell RA. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 1996;384:368-372.
52. Vaux DL, Korsmeyer SJ. Cell death in development. Cell 1999;96:245-254.
53. De la Rosa EJ, De Pablo F. Cell death in early neural development: Beyond the neurotrophic theory. Trends Neurosci 2000;23:454-458.
54. Schwartz R, Teramo KA. Pregnancy: outcomes in the Diabetes Control and Complications Trial. Am J Obstet Gynecol 1996;174:1343-1353.
55. Chang TI, Loeken MR. Genotoxicity and diabetic embryopathy: Impaired expression of developmental control genes as a cause of defective morphogenesis. Semin Reprod Endocrinol 1999;17:153-165.
56. Garcia-Patterson A, Erdozain L, Ginovart G, Adelantado JM, Cubero JM, Gallo G, de Leiva A, Corcoy R. In human gestational diabetes mellitus congenital malformations are related to pre-pregnancy body mass index and to severity of diabetes. Diabetologia 2004;47:509-514.
57. Hendricks KA, Nuno OM, Suarez L, Larsen R. Effects of hyperinsulinemia and obesity on risk of neural tube defects among Mexican Americans. Epidemiology 2001;12:630-635.