Suppression of 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis by pre-initiation treatment of rats with β-naphthoflavone coincides with decreased levels of the carcinogen-derived DNA adducts in the mammary gland

Cancer Detection and Prevention

Volumn 29, Issue 4, 2005, Pages 338-347

  Malejka Giganti, Danuta ^a,b   Bennett, Kristen K ^a   Culp, Sandra J ^c   Beland, Frederick A ^c   Shinozuka, Hisashi ^d   Bliss, Robin L ^e  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Naphthoflavone; 7,12 Dimethylbenz a anthracene; Enzyme activity determination; Mammary DNA adducts in vivo; Mammary gland carcinogenesis; Nifedipine oxidation (NIFOX); Phase I phase II enzymes; Suppression

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; BETA NAPHTHOFLAVONE; CARCINOGEN; CORN OIL; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2B1; CYTOCHROME P450 2B2; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE; LIVER ENZYME; URIDINE DIPHOSPHATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOASSAY; BREAST ADENOCARCINOMA; BREAST CARCINOGENESIS; CONTROLLED STUDY; DETOXIFICATION; DNA ADDUCT; DRUG EFFECT; ENZYME ACTIVITY; FEMALE; GLUCURONIDATION; LIVER; MAMMARY GLAND; NONHUMAN; PREMEDICATION; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ADENOCARCINOMA; ANIMALS; BETA-NAPHTHOFLAVONE; CARCINOGENS; CYTOCHROME P-450 ENZYME SYSTEM; DISEASE MODELS, ANIMAL; DNA ADDUCTS; ENZYME INDUCTION; ENZYME INHIBITORS; FEMALE; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE; LIVER; MAMMARY GLANDS, ANIMAL; MAMMARY NEOPLASMS, EXPERIMENTAL; RATS; RATS, SPRAGUE-DAWLEY;

EID: 24644475812     PISSN: 0361090X     EISSN: 15251500     Source Type: Journal    
DOI: 10.1016/j.cdp.2005.01.005     Document Type: Article

References (45)

1. L.W. Wattenberg Inhibitors of chemical carcinogenesis Adv Cancer Res 26 1978 197 226
2. C.R. Jefcoate Integration of xenobiotic metabolism in carcinogen activation and detoxication J. Caldwell W.B. Jakoby Biological basis of detoxification 1983 New York Academic Press 31 76
3. L.W. Wattenberg Chemoprevention of cancer Cancer Res 45 1985 1 8
4. M.A. Morse, and G.D. Stoner Cancer chemoprevention: principles and prospects Carcinogenesis 14 1993 1737 1746
5. D.T.H. Verhoeven, H. Verhagen, and R.A. Goldbohm A review of mechanisms underlying anticarcinogenicity by brassica vegetables Chem Biol Interact 103 1997 79 129
6. S.H. Safe Modulation of gene expression and endocrine response pathways by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds Pharmacol Ther 67 1995 247 281
7. L.W. Wattenberg, and J.L. Leong Inhibition of the carcinogenic action of 7,12-dimethylbenz(a)anthracene by beta-naphthoflavone Proc Soc Exp Biol Med 128 1968 940 943
8. D. Malejka-Giganti, G.A. Niehans, and M.A. Reichert Post-initiation treatment of rats with indole-3-carbinol or β-naphthoflavone does not suppress 7,12-dimethylbenz[a]anthracene-induced mammary gland carcinogenesis Cancer Lett 160 2000 209 218
9. C.L. Ritter, W.F. Prigge, and M.A. Reichert Oxidations of 17β-estradiol and estrone and their interconversions catalyzed by liver, mammary gland and mammary tumor after acute and chronic treatment of rats with indole-3-carbinol or β-naphthoflavone Can J Physiol Pharmacol 79 2001 519 532
10. J. Piskorska-Pliszczynska, B. Keys, and S. Safe The cytosolic receptor binding affinities and AHH induction potencies of 29 polynuclear aromatic hydrocarbons Toxicol Lett 34 1986 67 74
11. M. Roy, N. Fernandez, and P. Lesca Binding characteristics of 4-S proteins from rat and mouse liver. High affinity of ellipticines Eur J Biochem 172 1988 593 599
12. R.A. Lubet, C.R. Jones, and D.L. Stockus Induction of cytochrome P450 and other drug metabolizing enzymes in rat liver following dietary exposure to Aroclor 1254 Toxicol Appl Pharmacol 108 1991 355 365
13. F.P. Guengerich, M.V. Martin, and P.H. Beaune Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism J Biol Chem 261 1986 5051 5060
14. K.W. Bock, B. Burchell, and G.J. Dutton UDP-glucuronosyltransferase activities. Guidelines for consistent interim terminology and assay conditions Biochem Pharmacol 32 1983 953 955
15. W.H. Habig, M.J. Pabst, and W.B. Jakoby Glutathione S-transferase. The first enzymatic step in mercapturic acid formation J Biol Chem 249 1974 7130 7139
16. F.A. Beland, K.L. Dooley, and D.A. Casciano Rapid isolation of carcinogen-bound DNA and RNA by hydroxyapatite chromatography J Chromatogr 174 1979 177 186
17. M.V. Reddy, R.C. Gupta, and E. Randerath 32P-postlabeling test for covalent DNA binding of chemicals in vivo: application to a variety of aromatic carcinogens and methylating agents Carcinogenesis 5 1984 231 243
18. S.J. Culp, M.C. Poirier, and F.A. Beland Biphasic removal of DNA adducts in a repetitive DNA sequence after dietary administration of 2-acetylaminofluorene Environ Health Perspect 99 1993 273 276
19. M.G. Manjanatha, L.E. Lyn-Cook, and S.J. Culp Lymphocyte mutant frequency in relation to DNA adduct formation in rats treated with tumorigenic doses of the mammary gland carcinogen 7,12-dimethylbenz[a]anthracene Mutat Res 357 1996 89 96
20. D.C. Montgomery Design and analysis of experiments 3rd ed. 1991 Wiley New York
21. C.T. Le Applied survival analysis 1997 Wiley New York
22. A. Agresti Multinomial response models Categorical data analysis 1990 Wiley New York p. 306-346
23. C.W. Welsch Relationship between dietary fat and experimental mammary tumorigenesis: a review and critique Cancer Res 52 1992 2040s 2048s
24. L.A. Cohen, J. Chen-Backlund, and D.W. Sepkovic Effect of varying proportions of dietary menhaden and corn oil on experimental rat mammary tumor promotion Lipids 28 1993 449 456
25. C. Ip, and J.A. Scimeca Conjugated linoleic acid and linoleic acid are distinctive modulators of mammary carcinogenesis Nutr Cancer 27 1997 131 135
26. N.M. Wilson, M. Christou, and C.R. Turner Binding and metabolism of benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene by seven purified forms of cytochrome P-450 Carcinogenesis 5 1984 1475 1483
27. M. Christou, C.J. Moore, and M.N. Gould Induction of mammary cytochromes P-450: an essential first step in the metabolism of 7,12-dimethylbenz[a] anthracene by rat mammary epithelial cells Carcinogenesis 8 1987 73 80
28. Y.M. Sheikh, F.B. Daniel, and D.T. Witiak Metabolism of 7,12-dimethylbenz(a)anthracene. Correlation of dihydrodiol and phenol metabolites with organ susceptibility to carcinogenesis in Sprague-Dawley and Long-Evans rats Drug Metab Dispos 11 1983 158 163
29. M. Shou, K.R. Korzekwa, and K.W. Krausz Specificity of cDNA-expressed human and rodent cytochrome P450s in the oxidative metabolism of the potent carcinogen 7,12-dimethylbenz[a]anthracene Mol Carcinog 17 1996 241 249
30. M. Christou, U. Savas, and S. Schroeder Cytochromes CYP1A1 and CYP1B1 in the rat mammary gland: cell-specific expression and regulation by polycyclic aromatic hydrocarbons and hormones Mol Cell Endocrinol 115 1995 41 50
31. A.F. Trombino, R.I. Near, and R.A. Matulka Expression of the aryl hydrocarbon receptor/transcription factor (AhR) and AhR-regulated CYP1 gene transcripts in a rat model of mammary tumorigenesis Breast Cancer Res Treat 63 2000 117 131
32. A.F. Badawi, E.L. Cavalieri, and E.G. Rogan Effect of chlorinated hydrocarbons on expression of cytochrome P450 1A1, 1A2 and 1B1 and 2- and 4-hydroxylation of 17β-estradiol in female Sprague-Dawley rats Carcinogenesis 21 2000 1593 1599
33. T.L. Horn, M.A. Reichert, and R.L. Bliss Modulations of P450 mRNA in liver and mammary gland and P450 activities and metabolism of estrogen in liver by treatment of rats with indole-3-carbinol Biochem Pharmacol 64 2002 393 404
34. J.G. Liehr, and M.J. Ricci 4-Hydroxylation of estrogens as a marker of human mammary tumors Proc Natl Acad Sci USA 93 1996 3294 3296
35. J.-Z. Liu, B.-Z. Zhang, and J.A. Milner Dietary selenite modifies glutathione metabolism and 7,12-dimethylbenz(a)anthracene conjugation in rats J Nutr 124 1994 172 180
36. J. Liu, K. Gilbert, and H.M. Parker Inhibition of 7,12-dimethylbenz(a) anthracene-induced mammary tumors and DNA adducts by dietary selenite Cancer Res 51 1991 4613 4617
37. A. Izzotti, A. Camoirano, and C. Cartiglia Patterns of DNA adduct formation in liver and mammary epithelial cells of rats treated with 7,12-dimethylbenz(a)anthracene, and selective effects of chemopreventive agents Cancer Res 59 1999 4285 4290
38. R. Todorovic, F. Ariese, and P. Devanesan Determination of benzo[a]pyrene- and 7,12-dimethylbenz[a]anthracene-DNA adducts formed in rat mammary glands Chem Res Toxicol 10 1997 941 947
39. H. Zarbl, S. Sukumar, and A.V. Arthur Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats Nature 315 1985 382 385
40. T. Vuorio, A. Warri, and M. Sandberg Expression of the c-Ha-ras and neu oncogenes in DMBA-induced, anti-estrogen-treated rat mammary tumors Int J Cancer 42 1988 774 779
41. C. Chiodino, R.F. Jones, and S.P. Ethier The role of Ha-ras oncogenes in growth factor independence in rat mammary carcinoma cells Mol Carcinog 4 1991 286 296
42. K. Kito, T. Kihana, and A. Sugita Incidence of p53 and Ha-ras gene mutations in chemically induced rat mammary carcinomas Mol Carcinog 17 1996 78 83
43. M.G. Manjanatha, S.D. Shelton, and S.J. Culp DNA adduct formation and molecular analysis of in vivo lacI mutations in the mammary tissue of Big Blue rats treated with 7,12-dimethylbenz[a]anthracene Carcinogenesis 21 2000 265 273
44. R.H. Heflich, R.A. Mittelstaedt, and M.G. Manjanatha DNA sequence analysis of hprt mutations in lymphocytes from Sprague-Dawley rats treated with 7,12-dimethylbenz[a]anthracene Environ Mol Mutagen 28 1996 5 12
45. R.A. Mittelstaedt, M.G. Manjanatha, and S.D. Shelton Comparison of the types of mutations induced by 7,12-dimethylbenz[a]anthracene in the lacI and hprt genes of Big Blue rats Environ Mol Mutagen 31 1998 149 156