Effects of single and repeated exposure to biocidal active substances on the barrier function of the skin in vitro

Regulatory Toxicology and Pharmacology

Volumn 43, Issue 1, 2005, Pages 76-84

  Buist, Harrie E ^a   Van De Sandt, Johannes J M ^a   Van Burgsteden, Johan A ^a   De Heer, Cees ^a  

^a TNO   (Netherlands)

Author keywords

Biocidal active substances; Dermal absorption; Quaternary ammonium chlorides; Repeated exposure; Risk assessment; Single exposure; Skin barrier

Indexed keywords

AMMONIUM DERIVATIVE; BIOCIDE; BORIC ACID; DELTAMETHRIN; FORMALDEHYDE; PERMETHRIN; PIPERONYL BUTOXIDE; QUATERNARY AMMONIUM DERIVATIVE; SODIUM BROMIDE; TEBUCONAZOLE; UNCLASSIFIED DRUG; WATER;

ADULT; ARTICLE; CONTROLLED STUDY; DILUTION; EXPOSURE; FEMALE; HUMAN; HUMAN TISSUE; INTERMETHOD COMPARISON; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RISK ASSESSMENT; SKIN ABSORPTION; SKIN FUNCTION; SKIN PENETRATION; SKIN PERMEABILITY; STATISTICAL SIGNIFICANCE; TITRIMETRY;

ADULT; BENZALKONIUM COMPOUNDS; CARBON RADIOISOTOPES; DETERGENTS; DEUTERIUM OXIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MIDDLE AGED; PERFUSION; PERMEABILITY; PROPOXUR; QUATERNARY AMMONIUM COMPOUNDS; SKIN ABSORPTION; SKIN PHYSIOLOGY;

EID: 24644475769     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2005.06.006     Document Type: Article

References (21)

1. R.E. Baynes, K.B. Halling, and J.E. Riviere The influence of diethyl-m-toluamide (DEET) on the percutaneous absorption of permethrin and carbaryl Toxicol. Appl. Pharmacol. 144 2 1997 332 339
2. K.H. Beyer, W.F. Bergfeld, W.O. Berndt, R.K. Boutwell, W.W. Carlton, D.K. Hoffmann, and A.L. Schroeter Final report on the safety assessment of sodium borate and boric acid J. Am. Coll. Toxicol. 2 7 1983 87 125
3. D.A. Bucks, J.P. Marty, and H.I. Maibach Percutaneous absorption of malathion in the guinea-pig: Effect of repeated topical application Food Chem. Toxicol. 23 10 1985 919 922
4. Buist, H.E., Bessems, J.G.M., van de Sandt, J.J., Schurz, F., de Heer, C., 2003. Dermal absorption after repeated exposure to biocidal active substances. A discussion paper and research proposal. TNO report V5491. TNO Chemistry, Zeist, Netherlands.
5. ECB, 2003. Technical Guidance Document on Risk Assessment. Part I. European Chemicals Bureau, Ispra, Italy.
6. EPA, 1998. Health Effects Test Guidelines OPPTS 870.7600. Dermal Penetration. United States Environmental Protection Agency, Washington DC, USA.
7. EU, 1998. Directive 98/8/EC of the European parliament and of the council of 16 February concerning the placing of biocidal products on the market. Official Journal of the European Communities L 123, 1-63.
8. EU, 2004. Annex I to Directive 67/548/EEC on Classification and Labelling of Dangerous Substances. Latest update by ATP 29. Official Journal of the European Communities L 152, 1-316. EU, Brussels, Belgium.
9. H. Heck, and M. Casanova-Schmitz Biochemical toxicology of formaldehyde Rev. Biochem. Toxicol. 6 1984 155 189
10. M. HéRy, G. Hecht, J.M. Gerber, G. Hubert, I. Subra, S. Aubert, F. Gerardin, and M. Dorotte Occupational exposure during cleaning and disinfection in the food industry Occup. Hyg. 5 2 1999 131 144
11. 14C) formaldehyde after topical exposure to rats, guinea pigs, and monkeys J. Gibson Formaldehyde Toxicity 1983 Hemisphere Publishing Corporation Washington, DC, USA 38 50
12. R. Kavlock, N. Chernoff, R. Baron, R. Linder, E. Rogers, B. Carver, J. Dilley, and V. Simmon Toxicity studies with decamethrin, A synthetic pyrethroid insecticide Environ. Pathol. Toxicol. 2 3 1979 751 765
13. G.H. Lin, and M. Hemming Ocular and dermal irritation studies of some quaternary ammonium compounds Food Chem. Toxicol. 34 2 1996 177 182
14. OECD, 2004a. Skin absorption: in vitro method. OECD guideline for testing of chemicals. Guideline 428. Organisation for Economic Co-operation and Development, Paris, France.
15. OECD, 2004b. Skin absorption: in vivo method. OECD guideline for testing of chemicals. Guideline 427. Organisation for Economic Co-operation and Development, Paris, France.
16. G. Perger, and D. Szadkowski Toxicology of pyrethroids and their relevance to human health Ann. Agric. Environ. Med. 1 1 1994 11 17
17. S. Selim, F.J. Preiss, K.L. Gabriel, J.H. Jonkman, and T.G. Osimitz Absorption and mass balance of piperonyl butoxide following an 8-h dermal exposure in human volunteers Toxicol. Lett. 107 1-3 1999 207 217
18. TNsG, 2002. Technical notes for guidance. Human exposure to biocidal products - guidance on exposure estimation. European Commission, DG Environment, Brussels, Belgium.
19. J.J.M. van de Sandt, W.J.A. Meuling, G.R. Elliott, N.H.P. Cnubben, and B.C. Hakkert Comparitive in vitro-in vivo percutaneous absorption of the pesticide propoxur Toxicol. Sci. 58 2000 23 31
20. J.J.M. van de Sandt, and A.A.J.J.L. Rutten Differential effects of chemical irritants in rabbit and human skin organ cultures Toxicol. In Vitro 9 2 1995 157 168
21. J.J.M. van de Sandt, A.A.J.J.L. Rutten, and B. van Ommen Species-specific cutaneous biotransformation of the pesticide propoxur during percutaneous absorption in vitro Toxicol. Appl. Pharmacol. 123 1993 144 150