Review of neuroendocrine correlates of chronic opiate misuse: Dysfunctions and pathophysiological mechanisms

Addictive Disorders and their Treatment

Volumn 4, Issue 3, 2005, Pages 99-109

  George, Sanju ^a   Murali, Vijaya ^b   Pullickal, Ravindranath ^b  

^a The Cottage   (United Kingdom)

^b Addictive Behaviours Centre   (United Kingdom)

Author keywords

Hormonal dysfunctions and pathophysiology; Methadone maintenance; Neuroendocrine changes; Opiate misuse

Indexed keywords

ANDROSTANOLONE; CALCITONIN; CORTICOSTEROID; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; DIAMORPHINE; ESTROGEN; FOLLITROPIN; GLUCOSE; GONADORELIN; GROWTH HORMONE; INSULIN; LIOTHYRONINE; LUTEINIZING HORMONE; METHADONE; METYRAPONE; OPIATE; PARATHYROID HORMONE; PROLACTIN; PROLACTOSTATIN; PROTIRELIN; TESTOSTERONE; THYROTROPIN; THYROXINE; THYROXINE BINDING GLOBULIN;

ABSTINENCE; AMENORRHEA; CHRONIC DISEASE; CIRCADIAN RHYTHM; DRUG DEPENDENCE; DRUG DEPENDENCE TREATMENT; EJACULATION DISORDER; ENDOCRINE DISEASE; ERECTILE DYSFUNCTION; GLUCOSE METABOLISM; HEROIN DEPENDENCE; HORMONE RELEASE; HUMAN; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; INFERTILITY; LIBIDO DISORDER; METHADONE TREATMENT; NEUROENDOCRINOLOGY; NON INSULIN DEPENDENT DIABETES MELLITUS; OPIATE ADDICTION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; SEXUAL DYSFUNCTION; SEXUAL FUNCTION; TREATMENT OUTCOME;

EID: 24644474698     PISSN: 15315754     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.adt.0000161633.63378.fb     Document Type: Review

References (70)

1. Hartnoll R, Lewis R, Mitcheson M, et al. Estimating the prevalence of opioid dependence. Lancet. 1985 Jan. 26;1:203-205.
2. Farrell M, Ward J, Mattick R, et al. Methadone maintenance treatment in opiate dependence: a review. BMJ. 1994;309:997-1001.
3. Marsch LA. The efficacy of methadone maintenance interventions in reducing illicit opiate use, HIV risk behaviour and criminality: a meta analysis. Addiction. 1998;93:515-532.
4. Kreek MJ. Medical complications in methadone patients. Ann N Y Acad Sci. 1978;311:110-134.
5. Stimmel BH, Vernace S, Tobias H. Hepatic dysfunction in heroin addicts: the role of alcohol. JAMA. 1972;222:811.
6. Nelson AS. Medical problems associated with addiction to opioid drugs. Int J Addict. 1966;1: 50-61.
7. Louria DB, Hensle T, Rose J. The major medical complications of heroin addiction. Ann Intern Med. 1967;67:1-22.
8. Oppenheimer E, Tobutt C, Taylor C, et al. Death and survival in a cohort of heroin addicts from London clinics: a 22-year follow-up study. Addiction. 1994; 89:1299-1308.
9. Cushman P Jr. Plasma testosterone in narcotic addiction. Am J Med. 1973;55:452-458.
10. Cushman P, Kreek MJ. Methadone-maintained patients: effect of Methadone on plasma testosterone, FSH, LH and Prolactin. N Y State J Med. 1974;74: 1970-1973.
11. Ragni G, De Lauretis L, Bestetti O, et al. Gonadal function in male heroin and methadone addicts. Int J Androl. 1988;11:93-100.
12. Martin WR, Jasinski DR, Haertzen CA, et al. Methadone-a re-evaluation. Arch Gen Psychiatry. 1973:28:286-295.
13. Mendelson JH, Mendelson JE, Patch VD. Plasma testosterone levels in heroin addiction and during methadone maintenance. J Pharmacol Exp Ther. 1975;192:211-217.
14. Azizi F, Vagenakis AG, Longcope C, et al. Decreased serum testosterone concentration in male heroin and methadone addicts. Steroids. 1973;22:467-472.
15. Brambilla F, Sacchetti E, Brunetta M. Pituitary-gonadal function in heroin addicts. Neuropsychobiology. 1977;3:160-166.
16. Brambilla F, Resele L, De Maio D, et al. Gonadotrophin response to synthetic gonadotropin hormone releasing hormone (GnRH) in heroin addicts. Am J Psychiatry. 1979;136:314-317.
17. Mirin SM, Meyer RE, Mendelson JH, et al. Opiate use and sexual function. Am J Psychiatry. 1980;137: 909-915.
18. Cicero TJ, Bell RD, Wiest WG, et al. Function of the male sex organs in heroin and methadone users. N Engl J Med. 1975;292:882-887.
19. Malik SA, Khan C, Jabbar A, et al. Heroin addiction and sex hormones in males. J Pak Med Assoc. 1992; 42:210-212.
20. Bolelli G, Lafisca S, Flamigni C, et al. Heroin addiction: relationship between the plasma levels of testosterone, dihydrotestosterone, androstenedione, LH, FSH and the plasma concentration of heroin. Toxicology. 1979:15:19-29.
21. Mendelson JH, Mello NK. Plasma testosterone levels during chronic heroin use and protracted abstinence. Clin Pharmacol Ther. 1975;17:529-533.
22. Afrasiabi MA, Flomm M, Friedlander H, et al. Endocrine studies in heroin addicts. Psychoneuroendocrinology. 1979;4:145-153.
23. Pelosi MA, Sama JC, Caterini H, et al. Galactorrhoea-amenorrhoea syndrome associated with heroin addiction. Am J Obstet Gynecol. 1974;118: 966-969.
24. Hellman L, Fukushima DK, Roffwarg H, et al. Changes in estradiol and cortisol production rates in men under the influence of narcotics. J Clin Endocrinol Metab. 1975;41:1014-1018.
25. Cushman P Jr. Sexual behaviour in heroin addiction and methadone maintenance. Correlation with plasma LH. N Y State J Med. 1972;72:1261-1265.
26. Wieland WE, Yunger M. Sexual effects and side effects of heroin and Methadone. Proceedings of the Third National Conference on Methadone Treatment. 1970;Washington DC.
27. th Meeting of the Endocrine Society. Chicago.
28. Mathis JL. Sexual aspects of heroin addiction. Med Aspects Hum Sex. 1970;4:98-108.
29. Cicero RJ. Effects of exogenous and endogenous opiates on the hypothalamic pituitary gonadal axis in the male. Fed Proc. 1980;39:2551-2554.
30. Mendelson JH, Ellingboe J, Kuehnle J, et al. Heroin and Naltrexone effects on pituitary-gonadal hormones in man: tolerance and super sensitivity. NIDA Res Monogr. 1979;27:302-308.
31. Wang C, Chan V, Yeung RT. The effect of heroin addiction on pituitary-testicular function. Clin Endocrinol (Oxf). 1978;9:455-461.
32. Cooper AJ. Factors in male sexual inadequacy: a review. J Nerv Ment Dis. 1969;149:337.
33. Cushman P Jr, Bordier B. Hypothalamic-pituitary-adrenal axis in methadone treated heroin addicts. J Clin Endocrinol Metab. 1970;30:24-29.
34. Kreek MJ, Wardlaw SL, Hartman N, et al. Circadian rhythms and levels of beta-endorphin, ACTH and cortisol during chronic methadone maintenance in humans. Life Sci. 1983;33:409-411.
35. Dackis CA, Gurpegui M, Pottash ALC, et al. Methadone induced hypoadrenalism. Lancet. 1982;2: 1167.
36. Paroli E, Melchiorri P. Inhibitory effect of morphine on metabolism of adrenal and testicular steroids. Biochem Pharmacol. 1961;6:18-20.
37. Kreek MJ, Ragunath J, Plevy S, et al. ACTH, Cortisol and beta-endorphin response to metyrapone testing during chronic methadone maintenance treatment in humans. Neuropeptides. 1984;5:277-278.
38. Brown LS, Singer F, Killian P. Endocrine complications of AIDS and Drug Addiction. Endocrinol Metab Clin North Am. 1991;20:655-671.
39. Facchinetti F, Grasso A, Petraglia E et al. Impaired Circadian rhythmicity of beta-lipotropin, beta-endorphin and ACTH in heroin addicts. Acta Endocrinol (Copenh). 1984;105:149-155.
40. Pullan PT, Watson FE, Seow SSW, et al. Methadone induced hypoadrenalism. Lancet. 1983;1:714.
41. Glass L, Rajegowda BK, Mukherjee TK, et al. Effect of Heroin on corticosteroid production in pregnant addicts and their foetuses. Am J Obstet Gynecol. 1973;117:416-418.
42. Tennant F, Shannon JA, Nork JG, et al. Abnormal adrenal metabolism in opioid addicts: implications for clinical treatment. J Psychoactive Drugs. 1991; 23:135-149.
43. Ceriello A, Giugliano D, Passariello N, et al. Impaired glucose metabolism in heroin and methadone users. Horm Metab Res. 1987;19:430-433.
44. Reed JL, Ghodse AH. Oral glucose tolerance and hormonal response in Heroin-dependent males. BMJ. 1973;2:582-585.
45. Giugliano D, Quatraro A, Consoli G, et al. Sodium salicylate restores the impaired insulin response to glucose and improves glucose tolerance in heroin addicts. Acta Diabetol. 1987;24:205-212.
46. Vescovi PP, Gerra G, Rastelli G, et al. Effect of metaadone on TSH and thyroid hormone secretion. Horm Metab Res. 1984;16:53-54.
47. Passariello ND, Giugliano A, Quatraro G, et al. Glucose tolerance and hormonal responses in heroin addicts: a possible role for endogenous opiates in the pathogenesis of non-insulin dependent diabetes. Metabolism. 1983;32:1163-1165.
48. Ghodse AH. Evaluation of blood glucose, insulin, GH and cortisol response in Heroin addicts. Pahlavi Med J. 1977;8:141-156.
49. Desser KB, Arvin S. Diabetic ketoacidosis during acute heroin abstinence. Lancet. 1969;2:689.
50. Ghodse AH, Reed JL. Gastric emptying, glucose tolerance and associated hormonal changes in heroin addiction. Psychol Med. 1984;14:521-525.
51. Giugliano D. Morphine, opioid peptides and pancreatic islet function. Diabetes Care. 1984;7:92-98.
52. Shenkman L, Massie B, Mitsuma T, et al. Effects of chronic methadone administration on the hypothalamic-pituitary-thyroid axis. J Clin Endocrinol Metab. 1972;35:169-170.
53. Rasheed A, Tareen IA. Effects of heroin on thyroid function, cortisol and Testosterone level in addicts. Pol J Pharmacol. 1995;47:441-444.
54. Azizi F, Vagenakis AG, Portnay GI, et al. Thyroxine transport and metabolism in methadone and heroin addicts. Ann Intern Med. 1974;80:194-199.
55. English T, Ruxton D, Eastman CJ. Abnormalities in thyroid function associated with chronic therapy with methadone. Clin Chem. 1988;34:2202-2204.
56. Bastomsky CH, Dent RM, Tolis G. Elevated serum concentrations of TBG and Ceruloplasmin in methadone maintained patients. Clin Biochem. 1977;10: 124-126.
57. Schussler GC, Stimmel B, Korn F. Increased serum thyroid hormone binding in narcotic addicts is due to liver disease. Am J Drug Alcohol Abuse. 1980;7: 379-387.
58. Webster JB, Coupal JJ, Cushman P Jr. Increased serum thyroxine levels in Euthyroid narcotic addicts. J Clin Endocrinol Metab. 1973;37:928-934.
59. Delitala G, Grossman A, Besser M. Differential effects of opiate peptides and Alkaloids on anterior pituitary hormone secretion. Neuroendocrinology. 1983;37: 275-279.
60. Spagnolli W, Torboli P, Mattarei M, et al. Calcitonin and prolactin serum levels in heroin addicts: study on a methadone treated group. Drug Alcohol Depend. 1987;70:143-148.
61. Willenbring ML, Morley JE, Krahn DD, et al. Psychoneuroendocrine effects of methadone maintenance. Psychoneuroendocrinology. 1989;14: 371-391.
62. Lafisca S, Bolelli G, Franceschetti F, et al. Hormone levels in methadone-treated drug addicts. Drug Alcohol Depend. 1981;8:229-234.
63. Woody G, McLellan AT, O'Brein C, et al. Hormone secretion in methadone dependent and abstinent patients. NIDA Res Monogr. 1998;81:216-223.
64. Committee on Safety of Medicines. ADROIT System, Drug Analysis. Medicines and Health Care Products Regulatory Agency, West Midlands, UK; 2002.
65. Tolis G, Dent R, Guyda H. Opiates, PRL and Dopamine Receptor. J Clin Endocrinol Metab. 1978; 47:200-203.
66. Tagliaro F, Dorizzi R, Lafisca S, et al. Calcitonin serum levels in heroin addicts: effects of methadone and clonidine detox treatments. Drug Alcohol Depend. 1985;16:181-183.
67. Tagliaro F, Capra F, Dorizzi R, et al. High Serum calcitonin levels in heroin addicts. J Endocrinol Invest. 1984;7:331-333.
68. Pedrazzoni M, Vescovi PP. Effects of chronic heroin abuse on bone and mineral metabolism. Acta Endocrinol (Copenh). 1993;129:42-45.
69. Cushman P Jr. Growth hormone in narcotic addiction. J Clin Endocrinol Metab. 1972;35:352-358.
70. Department of Health. Statistics from the regional drug misuse databases on drug misusers in treatment in England, 2000/01 [Department of Health Website]. October 11, 2001. Available at: http://dh.gov.uli/Publications And Statistics/Press Releases/Press Releases Notices/fs/en?CONTENT_ID= 4011470&chk=e09fWg.