Fluticasone propionate plasma concentration and systemic effect: Effect of delivery device and duration of administration

Journal of Allergy and Clinical Immunology

Volumn 116, Issue 3, 2005, Pages 525-530

  Whelan, Glenn J ^a   Blumer, Jeffrey L ^c   Martin, Richard J ^a,b   Szefler, Stanley J ^a,b   Chinchilli, Vernon M ^d   Kraft, Monica ^d   Dolovich, Myrna ^d   Boushey, Homer A ^d   Cherniack, Reuben M ^d   Craig, Timothy J ^d   Drazen, Jeffrey M ^d   Fagan, Joanne K ^d   Fahy, John V ^d   Fish, James E ^d   Ford, Jean G ^d   Israel, Elliott ^d   Kunselman, Susan J ^d   Lazarus, Stephen C ^d   Lemanske Jr , Robert F ^d   Peters, Stephen P ^d   Sorkness, Christine A ^d   King, Tonya Sharp ^d   Mauger, Elizabeth ^d   more..

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

^d Office J329 ^*

Author keywords

Cortisol suppression; Drug accumulation; Dry powder inhaler; Fluticasone propionate; Metered dose inhaler; Pharmacokinetics; Steady state

Indexed keywords

FLUTICASONE PROPIONATE; HYDROCORTISONE;

ADULT; ANALYSIS OF VARIANCE; AREA UNDER THE CURVE; ARTICLE; ASTHMA; CORRELATION ANALYSIS; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG FORMULATION; HUMAN; LINEAR REGRESSION ANALYSIS; METERED DOSE INHALER; POWDER INHALER; PRIORITY JOURNAL; STEADY STATE;

ADMINISTRATION, INHALATION; ADULT; ANDROSTADIENES; ASTHMA; BRONCHODILATOR AGENTS; CLINICAL TRIALS; HUMANS; HYDROCORTISONE; METERED DOSE INHALERS; POWDERS; TIME FACTORS;

EID: 24644472938     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2005.05.044     Document Type: Article

References (32)

1. P.K. Yiallouros, A.D. Milner, E. Conway, and J.W. Honour Adrenal function and high dose inhaled corticosteroids for asthma Arch Dis Child 76 1997 405 410
2. L. Thorsson, S. Edsbacker, A. Kallen, and C.G. Lofdahl Pharmacokinetics and systemic activity of fluticasone via Diskus and pMDI, and of budesonide via Turbuhaler Br J Clin Pharmacol 52 2001 529 538
3. H. Mollmann, M. Wagner, S. Krishnaswami, H. Dimova, Y. Tang, and C. Falcoz Single-dose and steady-state pharmacokinetic and pharmacodynamic evaluation of therapeutically clinically equivalent doses of inhaled fluticasone propionate and budesonide, given as Diskus or Turbuhaler dry-powder inhalers to healthy subjects J Clin Pharmacol 41 2001 1329 1338
4. A.E. Mackie, J.E. McDowall, C. Falcoz, P. Ventresca, A. Bye, and P.T. Daley-Yates Pharmacokinetics of fluticasone propionate inhaled via the Diskhaler and Diskus powder devices in healthy volunteers Clin Pharmacokinet 39 2000 23 30
5. S. Goldberg, N. Algur, M. Levi, E. Brukheimer, H.J. Hirsch, and D. Branski Adrenal suppression among asthmatic children receiving chronic therapy with inhaled corticosteroid with and without spacer device Ann Allergy Asthma Immunol 76 1996 234 238
6. L. Agertoft, and S. Pedersen Effect of long-term treatment with inhaled budesonide on adult height in children with asthma N Engl J Med 343 2000 1064 1069
7. I.J. Doull, N.J. Freezer, and S.T. Holgate Growth of prepubertal children with mild asthma treated with inhaled beclomethasone dipropionate Am J Respir Crit Care Med 151 1995 1715 1719
8. I.J. Doull, M.J. Campbell, and S.T. Holgate Duration of growth suppressive effects of regular inhaled corticosteroids Arch Dis Child 78 1998 172 173
9. K.H. Carlsen, and J. Gerritsen Inhaled steroids in children: adrenal suppression and growth impairment Eur Respir J 19 2002 985 988
10. H.W. Kelly Establishing a therapeutic index for the inhaled corticosteroids, part I: pharmacokinetic/pharmacodynamic comparison of the inhaled corticosteroids J Allergy Clin Immunol 102 1998 S36 S51
11. H. Derendorf, G. Hochhaus, B. Meibohm, H. Mollmann, and J. Barth Pharmacokinetics and pharmacodynamics of inhaled corticosteroids J Allergy Clin Immunol 101 1998 S440 S446
12. C.L. Leach, P.J. Davidson, B.E. Hasselquist, and R.J. Boudreau Lung deposition of hydrofluoroalkane-134a beclomethasone is greater than that of chlorofluorocarbon fluticasone and chlorofluorocarbon beclomethasone: a cross-over study in healthy volunteers Chest 122 2002 510 516
13. C.L. Leach, P.J. Davidson, and R.J. Boudreau Improved airway targeting with the CFC-free HFA-beclomethasone metered-dose inhaler compared with CFC-beclomethasone Eur Respir J 12 1998 1346 1353
14. H. Derendorf, G. Hochhaus, S. Rohatagi, H. Mollmann, J. Barth, and H. Sourgens Pharmacokinetics of triamcinolone acetonide after intravenous, oral, and inhaled administration J Clin Pharmacol 35 1995 302 305
15. D. Argenti, B. Shah, and D. Heald A pharmacokinetic study to evaluate the absolute bioavailability of triamcinolone acetonide following inhalation administration J Clin Pharmacol 39 1999 695 702
16. C. Falcoz, R. Oliver, J.E. McDowall, P. Ventresca, A. Bye, and P.T. Daley-Yates Bioavailability of orally administered micronised fluticasone propionate Clin Pharmacokinet 39 2000 9 15
17. L. Thorsson, S. Edsbacker, and T.B. Conradson Lung deposition of budesonide from Turbuhaler is twice that from a pressurized metered-dose inhaler P-MDI Eur Respir J 7 1994 1839 1844
18. R.J. Martin, S.J. Szefler, V.M. Chinchilli, M. Kraft, M. Dolovich, and H.A. Boushey Systemic effect comparisons of six inhaled corticosteroid preparations Am J Respir Crit Care Med 165 2002 1377 1383
19. H. Chrystyn Is total particle dose more important than particle distribution? Respir Med 91 1997 17 19
20. W.E.S. Kamin, T. Genz, S. Roeder, G. Scheuch, T. Trammer, and R. Juenemann Mass output and particle size distribution of glucocorticosteroids emitted from different inhalation devices depending on various inspiratory parameters J Aerosol Med 12 2002 65 73
21. M.W. Nagel, K.J. Wiersema, S.L. Bates, and J.P. Mitchell Performance of large- and small-volume valved holding chambers with a new combination long-term bronchodilator / anti-inflammatory formulation delivered by pressurized metered dose inhaler J Aerosol Med 15 2002 427 433
22. C. Brindley, C. Falcoz, A.E. Mackie, and A. Bye Absorption kinetics after inhalation of fluticasone propionate via the Diskhaler, Diskus and metered-dose inhaler in healthy volunteers Clin Pharmacokinet 39 2000 1 8
23. S.J. Szefler, R.J. Martin, T.S. King, H.A. Boushey, R.M. Cherniack, and V.M. Chinchilli Asthma Clinical Research Network of the National Heart Lung, and Blood Institute. Significant variability in response to inhaled corticosteroids for persistent asthma J Allergy Clin Immunol 109 2002 410 418
24. S. Krishnaswami, H. Mollmann, H. Derendorf, and G. Hochhaus A sensitive LC-MS/MS method for the quantification of fluticasone propionate in human plasma J Pharm Biomed Anal 22 2000 123 129
25. W.F. Ebling, S.J. Szefler, and W.J. Jusko Analysis of cortisol, methylprednisolone, and methylprednisolone hemisuccinate absence of effect of trolenadomycin on ester hydrolysis J Chromatogr 305 1984 271 280
26. A.E. Mackie, J.E. McDowall, C. Falcoz, P. Ventresca, A. Bye, and P.T. Daley-Yates Pharmacokinetics of fluticasone propionate inhaled via the Diskhaler and Diskus powder devices in healthy volunteers Clin Pharmacokinet 39 2000 23 30
27. M.H. Brutsche, I.C. Brutsche, M. Munawar, S.J. Langley, C.M. Masterson, and P.T. Daley-Yates Comparison of pharmacokinetics and systemic effects of inhaled fluticasone propionate in patients with asthma and healthy volunteers: a randomised crossover study Lancet 356 2000 556 561
28. L. Thorsson, K. Dahlstrom, S. Edsbacker, A. Kallen, J. Paulson, and J.E. Wiren Pharmacokinetics and systemic effects of inhaled fluticasone propionate in healthy subjects Br J Clin Pharmacol 43 1997 155 161
29. J. Shen, J. He, V.C. Yeong, G. Paul, K. McHale, and N.C. Hughes Development of a high sensitivity LC-MS/MS method for fluticasone propionate: pharmacokinetic application in human subjects following nasal spray administration [abstract] Abstract 086. 51st Annual American Society of Mass Spectrometry conference, Montreal, Quebec, Canada, June 8-12, 2003
30. P.T. Daley-Yates, J. Tournant, and R.L. Kunka Comparison of the systemic availability of fluticasone propionate in healthy volunteers and patients with asthma Clin Pharmacokinet 391 2000 39 45
31. E. Derom, J. Van Schoor, W. Verhaeghe, W. Vincken, and R. Pauwels Systemic effects of inhaled fluticasone propionate and budesonide in adult patients with asthma Am J Respir Crit Care Med 160 1999 157 161
32. A.E. Mackie, J.E. McDowall, P. Ventresca, A. Bye, C. Falcoz, and P.T. Daley-Yates Systemic exposure to fluticasone propionate administered via metered-dose inhaler containing chlorofluorocarbon or hydrofluoroalkane propellant Clin Pharmacokinet 39 2000 17 22