Effect of Dianex, a herbal formulation on experimentally induced diabetes mellitus

Phytotherapy Research

Volumn 19, Issue 5, 2005, Pages 409-415

  Mutalik, S ^a   Chetana, M ^b   Sulochana, B ^b   Devi, P Uma ^c   Udupa, N ^a  

^a MANIPAL COLLEGE OF PHARMACEUTICAL SCIENCES   (India)

^b KASTURBA MEDICAL COLLEGE   (India)

^c Jawaharlal Nehru Cancer Hospital & Research Centre Bhopal   (India)

Author keywords

Diabetes mellitus; Dianex; Herbal formulation

Indexed keywords

AEGLE MARMELOSE EXTRACT; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; AZADIRACHTA INDICA EXTRACT; CASSIA EXTRACT; CREATININE; CURCUMA LONGA EXTRACT; DIANEX; GLUCOSE; GYMNEMA SYLVESTRE EXTRACT; HERBACEOUS AGENT; HIGH DENSITY LIPOPROTEIN; MOMORDICA CHARANTIA EXTRACT; PLANT EXTRACT; SCAVENGER; STREPTOZOCIN; SYZYGIUM CUMINI EXTRACT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UREA; WITHANIA SOMNIFERA EXTRACT;

AEGLE MARMELOSE; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AZADIRACHTA INDICA; BODY WEIGHT; CASSIA AURICULATA; CONTROLLED STUDY; DIABETES MELLITUS; DRUG ACTIVITY; DRUG DOSE REDUCTION; DRUG EFFECT; DRUG FORMULATION; DRUG MEGADOSE; DRUG SCREENING; DRUG TOLERABILITY; EUGENIA JAMBOLANA; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GLYCOGEN LIVER LEVEL; GYMNEMA SYLVESTRE; HISTOLOGY; HISTOPATHOLOGY; HYPOGLYCEMIA; LONG TERM CARE; MEDICINAL PLANT; MOMORDICA CHARANTIA; MOUSE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; SCAVENGING SYSTEM; STREPTOZOCIN DIABETES; WITHANIA SOMNIFERA;

ADMINISTRATION, ORAL; ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; CHOLESTEROL; DIABETES MELLITUS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FREE RADICAL SCAVENGERS; HYPOGLYCEMIC AGENTS; LIPOPROTEINS; LIVER; MALE; MICE; PANCREAS; PHYTOTHERAPY; PICRATES; PLANTS, MEDICINAL; STREPTOZOCIN; TRIGLYCERIDES;

AEGLE; ANIMALIA; AZADIRACHTA INDICA; CASSIA AURICULATA; CURCUMA LONGA; GYMNEMA SYLVESTRE; MOMORDICA CHARANTIA; SYZYGIUM CUMINI; WITHANIA SOMNIFERA;

EID: 24644467262     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ptr.1570     Document Type: Article

References (29)

1. Achrekar S, Kaklijs GS, Pote MS, Kelkar SM. 1991. Hypoglycemic activity of Eugenia jambolana and Ficus bengalensis: Mechanism of action. In vivo 5(2): 143-147.
2. Andallu B, Radhika B, Dawar R. 2000. Hypoglycemic, diuretic and hypocholesteremic effect of Winter cherry (Withania somnifera) Dunal root. Ind J Exp Biol 38(6): 607-609.
3. Annapurna A, Mahalaxmi K, Krishna MK. 2001. Antidiabetic activity of a polyherbal preparation (tincture of panchparna) in normal and diabetic rats. Ind J Exp Biol 39(5): 500-502.
4. Bajaj S, Srinivasan BP. 1999. Investigation into the antidiabetic activity of Azadirachta indica. Ind J Pharmacol 31: 138-141.
5. Bopanna KN, Kannan J, Gadgil S, et al. 1997. Antidiabetic and antihyperglycemic effects of neem seed kernel powder on alloxan diabetic rabbits. Ind J Pharmcol 27: 162-167.
6. Cai L, Kang YJ. 2001. Oxidative stress and cardiomyopathy. Cardiovasc Toxicol 1(3): 181-193.
7. Carrol NV, Longley RW, Roe JH. 1956. The determination of glycogen in liver and muscle by use of anthrone reagent. J Biol Chem 220: 583-585.
8. Chattopadhyaya R, Sarkar SK, Ganguly S, et al. 1992. Hepatoprotective activity of Azadirachta indica leaves on paracetamol induced hepatic damage in rats. Ind J Exp Biol 30(8): 738-740.
9. Chaurasia AK, Dubey SD, Ojha JK. 1994. Role of Vijayasara and Jarul on insulin dependent diabetes mellitus. Aryavaidyan 7(3): 147-152.
10. Das AV, Padayutti PS, Paulose CS. 1996. Effect of leaf extract of Aegle marmelose (L) Correa ex Roxb on histological and ultrastructural changes in tissues of streptozotocin induced diabetic rats. Ind J Exp Biol 34(4): 341-345.
11. Dubey GP, Dixit SP, Singh A. 1994. Alloxan induced diabetes in rabbits and effect of a herbal formulation D-400. Ind J Pharmcol 26: 225-226.
12. Grover JK, Rathi SS, Vats V. 2002. Amelioration of experimental diabetic neuropathy and gastropathy in rats following oral administration of plant (Eugenia jambolana, Mucurna pruriens and Tinospora cordifolia) extracts. Ind J Exp Biol 40(3): 273-276.
13. Grover JK, Vats V, Rathi SS, Dawar R. 2001. Traditional Indian antidiabetic plants attenuate progression of renal damage in streptozotocin induced diabetic mice. J Ethnopharmacol 76(3): 233-238.
14. Halliwell B, Gutteridge JMC, Aruoma OS. 1987. The deoxyribose method: a simple test tube assay for determination of rate constants for reactions of hydroxyl radicals. Anal Biochem 165: 215-219.
15. Kumari K, Augusti KT. 2002. Antidiabetic and antioxidant effects of S-methyl cystene sulfoxide isolated from onions (Allium cepa Linn) as compared to standard drugs in alloxan diabetic rats. Ind J Exp Biol 40(9): 1005-1009.
16. Lowry OH, Rosenbrough NJ, Farr AI, Randall RJ. 1951. Protein measurements with the Polin phenol reagent. J Biol Chem 193: 265-275.
17. Miller NJ, Evans RCA. 1997. Factors influencing the antioxidant activity by the ABTS radical cation assay. Free Rad Res 28(3): 195-199.
18. Mitra SK, Gopumadhavan S, Muralidhar TS. 1996. Effect of D-400, an ayurvedic herbal formulation on experimentally induced diabetes mellitus. Phytother Res 10: 433-435.
19. Mutalik S, Sulochana B, Chetana M, et al. 2003. Preliminary studies on acute and subacute toxicity of an antidiabetic herbal preparation, Dianex. Ind J Exp Biol 4: 316-320.
20. Nischino S, Hayami T, Ikeda I, Imaizumi K. 2000. Protection against the diabetogenic effect of feeding of terbutyl hydroquinone to rats prior to administration of streptozotocin. Biosci Biotechnol Biochem 64(6): 1153-1158.
21. Pari L, Ramakrishnan R, Venkateshwaran S. 2001. Anti-hyperglycemic effect of Diamed, a herbal formulation in experimental diabetes in rats. J Pharm Pharmacol 53(8): 1139-1143.
22. Ponnachan PT, Paulose CS, Panikkar KR. 1993. Effect of leaf extract of Aegle marmelose in diabetic rats. Ind J Exp Biol 31(4): 345-347.
23. Reynolds JEF. 1997. Martindale-The Extra Pharmacopoeia, 30th edn. The Pharmaceutical Press: London.
24. Scartezzini P, Speroni E. 2000. Review on some plants of Indian traditional medicine with antioxidant activity. J Ethnopharmacol 71(1-2): 23-43.
25. Song EK, Cho H, Kim JS, et al. 2001. Diarylheptanoids with free radical scavenging and hepatoprotective activity in vitro from Curcuma longa, Planta Med 67(9): 876-877.
26. Sreejayan N, Rao MNA. 1996. Free radical scavenging activity of Curcuminoids. Arzneimittel-Forschung/Drug Res 46: 169-171.
27. Upadhyay OP, Singh RM, Dutta K. 1996. Studies on antidiabetic medicinal plants used in Indian folk-lore. Aryavaidyan 9(3): 159-167.
28. Vasanthakumari V, Shyamaladevi CS. 1998. Biochemical evaluation of Tarakeshwara Rasa-Antidiabetic drug, in rats. Indian Drugs 35(3): 140-143.
29. Vetrichelvan T, Jagadeesan M, Adigala B, Uma Devi. 2002. Antidiabetic activity of alcoholic extract of Celosia argentea Linn seeds in rats. Biol Pharm Bull 25(4): 526-528.