Compound IKD-8344, a selective growth inhibitor against the mycelial form of Candida albicans, isolated fropm Streptomyces sp. A6792

Journal of Microbiology and Biotechnology

Volumn 15, Issue 4, 2005, Pages 909-912

  Hwang, Eui Il ^a   Yun, Bong Sik ^b   Yeo, Woon Hyung ^a   Lee, Sang Han ^b   Moon, Jae Sun ^b   Kim, Young Kook ^b   Lim, Se Jin ^c   Kim, Sung Uk ^b  

^a KT and G Corporation   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c Dongduk Women's University   (South Korea)

Author keywords

Candida albicans; Dimorphism; IKD 8344; Morphological change; Selectivity; Virulence

Indexed keywords

AMPHOTERICIN B; ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; CLOTRIMAZOLE; CYCLOHEXIMIDE; GROWTH INHIBITOR; IKD 8344; KETOCONAZOLE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CANDIDA KRUSEI; CANDIDA LUSITANIAE; CANDIDA TROPICALIS; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; GROWTH INHIBITION; IC 50; MASS SPECTROMETRY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR WEIGHT; MOUSE; MOUSE STRAIN; MYCELIUM; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SOIL; SPECIES; SPECTROSCOPY; STREPTOMYCES; ULTRAVIOLET SPECTROPHOTOMETRY;

CANDIDA; CANDIDA ALBICANS; CANDIDA TROPICALIS; STREPTOMYCES SP.;

EID: 24644445154     PISSN: 10177825     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Sudberg, P., N. Gow, and J. Berman. 2004. The distinct morphogenic states of Candida albicans. Trends Microbiol. 12: 317-324.
2. Sudoh, M., T. Yamazaki, K. Masucuchi, M. Taniguchi, N. Shimma, M. Arisawa, and H. Yamada-Okabe. 2000. Identification of a novel inhibitor specific to the fungal chitin synthase. J. Biol. Chem. 276: 32901-32906.
3. Cutler, J. E. 1991. Putative virulence factors of Candida albicans. Annu. Rev. Microbiol. 45: 187-218.
4. Calderone, R. A. and W. A. Fonzi. 2001. Virulence factors of Candida albicans. Trends Microbiol. 9: 327-335.
5. Haynes, K. 2001. Virulence in Candida species. Trends Microbiol. 9: 591-596.
6. Wenzet, R. P. 1995. Nosocomial candidiasis: Risk factors and attributable mortality. Clin. Infect. Dis. 20: 1531-1534.
7. Edmond, M. B., S. E. Wallace, D. K. Mcclish, M. A. Pfaller, R. N. Jones, and R. P. Wenzel. 1999. Nosocomial bloodstream infections in the United States hospitals: A three-year analysis. Clin. Infect. Dis. 29: 239-244.
8. Pfaller, M. A., D. J. Diekema, R. N. Jones, H. S. Sader, A. C. Fluit, R. J. Hollis, and S. A. Messer. 2001. International surveillance of bloodstream infections due to Candida species; frequency of occurance and in vitro susceptibilities to fluconazole, ravuconazole, and voriconazole of isolates collected from 1997 through 1999 in the SENTRY antimicrobial surveillance program. J. Clin. Microbiol. 39: 3254-3259.
9. Gow, N. A. R., A. J. P. Brown, and F. C. Odds. 2002. Fungal morphogenesis and host invasion. Curr. Opin. Microbiol. 5: 366-371.
10. Leberer, E., D. Harcus, I. D. Broadbent, K. L. Clark, D. Dignard, K. Ziegelbauer, A. Schmidt, N. A. R. Gow, A. J. P. Brown, and D. Y. Thomas. 1996. Signal transduction through homologs of the Ste20p and Ste7p protein kinases can trigger hyphal formation in the pathogenic fungus Candida albicans. Proc. Natl. Acad. Sci. USA 93: 13217-13222.
11. Brown, A. J. P. and N. A. R. Gow. 1999. Regulatory networks controlling Candida albicans morphogenesis. Trends Microbiol. 7: 333-338.
12. Lo, H. T., J. R. Kohler, B. DiDomenico, D. Loebenberg, A. Cacciapuoti, and G. R. Fink. 1997. Nonfilamentous C. albicans mutants are avirulent. Cell 90: 939-949.
13. Gale, C. A., C. M. Bendel, M. McClellan, M. Hauser, J. M. Becker, J. Berman, and M. K. Hostetter. 1998. Linkage of adhesion, filamentous growth, and virulence in Candida albicans to a single gene, INT1. Science 279: 1355-1358.
14. Hwang, E. I., B. S. Yun, S. H. Lee, S. K. Kim, S. J. Lim, and S. U. Kim. 2004. 7-Oxostaurosporine selectively inhibit the mycelial form of Candida albicans. J. Microbiol. Biotechnol. 14: 1067-1070.
15. Mcginnis, M. R. and M. G. Rinaldi. 1986. Antifungal drugs: Mechanisms of action, drug resistance, susceptibility testing, and assays of activity in biological fluids, pp. 243-260. In V. Lorian (ed.), Antibiotics in Laboratory Medicine. Williams & Wilkins, Baltimore.
16. Locci, R. 1989. Streptomycetes and related genera, pp. 2451-2492. In S. T. Williams, M. E. Sharpe, and J. G. Holt (eds.), Bergey's Manual of Systematic Bacteriology, Vol. 4. Williams and Wilkins, Baltimore.
17. Minami, Y., K. I. Yoshida, R. Azuma, M. Nishii, J. I. Inagaki, and F. Nohara. 1992. Structure of a novel macrodiolide antibiotic IKD-8344. Tetrahedron Lett. 33: 7373-7376.