Ursodeoxycholic acid therapy in children with cholestatic liver disease

Turkish Journal of Pediatrics

Volumn 41, Issue 1, 1999, Pages 91-98

  Dinler, Gönül ^a   Koçak, Nurten ^a   Yüce, Aysel ^a   Gürakan, Figen ^a   Özen, Hasan ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Children; Cholestatic liver disease; Ursodeoxycholic acid

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CHOLESTEROL; GAMMA GLUTAMYLTRANSFERASE; URSODEOXYCHOLIC ACID;

ADOLESCENT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CHILD; CHOLESTATIC HEPATITIS; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; DRUG SAFETY; DRUG TOLERABILITY; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HUMAN; INFANT; INTRAHEPATIC CHOLESTASIS; LIVER BIOPSY; NEWBORN HEPATITIS; PRURITUS; TREATMENT OUTCOME;

ADOLESCENT; AGE FACTORS; BIOPSY; CHILD; CHILD, PRESCHOOL; CHOLAGOGUES AND CHOLERETICS; CHOLESTASIS; DRUG MONITORING; HUMANS; INFANT; LIVER FUNCTION TESTS; PROSPECTIVE STUDIES; TREATMENT OUTCOME; URSODEOXYCHOLIC ACID;

EID: 2442757251     PISSN: 00414301     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Cirillo NW, Zwas FR. Ursodeoxycholic acid in the treatment of chronic liver disease. Am J Gastroenterol 1994; 89: 1447-1452.
2. Leuschner U, Güldütuna S, Imhof M, Hübner K, Benjaminov A, Leuschner M. Effects of ursodeoxycholic acid after 4 to 12 years of therapy in early and late stages of primary biliary cirrhosis. J Hepatol 1994; 21: 624-633.
3. Merli M, Bertasi S, Servi R, et al. Effect of a medium dose of ursodeoxycholic acid with or without taurine supplementation on the nutritional status of patients with cystic fibrosis: a randomized, placebo-controlled, crossover trial. J Pediatr Gastroenterol Nutr 1994; 19: 198-203.
4. Poupon RE, Balkau B, Eschwège E, Poupon R. A multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis. UDCA-PBC Study Group. N Engl J Med 1991; 324: 1548-1554.
5. Rolandi E, Franceschini R, Cataldi A, Cicchetti V, Carati L, Barreca T. Effects of ursodeoxycholic acid (UDCA) on serum liver damage indices in patients with chronic active hepatitis. A double-blind controlled study. Eur J Clin Pharmacol 1991; 40: 473-476.
6. Poupon R, Chrètien Y, Poupon RE, Ballet F, Calmus Y, Darnis F. Is ursodeoxycholic acid an effective treatment for primary biliary cirrhosis? Lancet 1987; 1: 834-836.
7. Hofmann AF. Pharmacology of ursodeoxycholic acid, an enterohepatic drug. Scand J Gastroenterol 1994; 204 (Suppl): 1-15.
8. Van de Meeberg PC, van Erpecum KJ, van Berge-Henegouwen GP. Therapy with ursodeoxycholic acid in cholestatic liver disease. Scand J Gastroenterol 1993; 200 (Suppl): 15-20.
9. Crosignani A, Podda M, Batrezatti PM, et al. Changes in bile acid composition in patients with primary biliary cirrhosis induced by ursodeoxycholic acid administration. Hepatology 1991; 14: 1000-1007.
10. Alonso EM, Snover DC, Montag A, Freese DK, Whitington PF. Histologic pathology of the liver in progressive familial intrahepatic cholestasis. J Pediatr Gastroenterol Nutr 1994; 18: 128-133.
11. Fawo O. Quantitative determination of serum bile acids using a purified 3α-hydroxysteroid dehydrogenase. Scand J Gastroenterol 1975; 10: 747-755.
12. nd ed). Connecticut: Appleton and Lange; 1994.
13. Colombo C, Setchell KD, Podda M, et al. Effects of ursodeoxycholic acid therapy for liver disease associated with cystic fibrosis. J Pediatr 1990; 117: 482-489.
14. Colombo C, Crosignani A, Assaisso M, et al. Ursodeoxycholic acid therapy in cystic fibrosis-associated liver disease: a dose response study. Hepatology 1992; 16: 924-930.
15. Balistreri WF, Heubi JE, Whitington P, Perrault J, Bancroft J, Setchell KD. Ursodeoxycholic acid (UDCA) therapy in pediatric hepatobiliary disease. Hepatology 1989; 10: A602.
16. Spagnuolo MI, Iorio R, Vegnente I, Guarino A. Ursodeoxycholic acid for treatment of cholestasis in children on long-term total parenteral nutrition: a pilot study. Gastroenterol 1996; 111. 716-719.
17. Ullrich D, Rating D, Schröter W, Hanefeld F, Bircher J. Treatment with ursodeoxycholic acid renders children with biliary atresia suitable for liver transplantation. Lancet 1987; 2: 1324.
18. Ikeda T, Tozuka S, Noguchi O, et al. Effects of additional administration of colchicine in ursodeoxycholic acid treated patients with primary biliary cirrhosis: a prospective randomized study. J Hepatol 1996; 24: 88-94.
19. Koçak N, Yüce A, Gürakan F, et al. Colchicine in the treatment of hepatic fibrosis in children. Am J Gastroenterol 1996; 91: 179-180.