Cisplatin-induced apoptosis of HeLa cells. Effect of RNA and protein synthesis inhibitors, Ca2+ chelators and zinc

Journal of Experimental and Clinical Cancer Research

Volumn 17, Issue 3, 1998, Pages 277-284

  Velazquez M ^a   Maldonado, V ^a   Melendez Zajgla, J ^a  

^a INSTITUTO NACIONAL DE CANCEROLOGÍA   (Mexico)

Author keywords

Actinomycin D; Apoptosis; Calcium; Cisplatin; Cycloheximide; EDTA; EGTA; HeLa cells; Zinc

Indexed keywords

CALCIUM; CALCIUM CHELATING AGENT; CISPLATIN; CYCLOHEXIMIDE; DACTINOMYCIN; DNA; EDETIC ACID; EGTAZIC ACID; RNA; ZINC ION;

APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DNA DEGRADATION; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RNA SYNTHESIS;

APOPTOSIS; CALCIUM; CELL SURVIVAL; CHELATING AGENTS; CISPLATIN; CYCLOHEXIMIDE; DACTINOMYCIN; DNA; EDETIC ACID; EGTAZIC ACID; HELA CELLS; HUMANS; KINETICS; NUCLEIC ACID SYNTHESIS INHIBITORS; PROTEIN SYNTHESIS INHIBITORS; RNA; ZINC;

EID: 2442743844     PISSN: 03929078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Schwartzman R.A., Cidlowski J.A.: Apoptosis: The Biochemistry and Molecular Biology of Programmed Cell Death. Endocrine Rev. 4: 133-155, 1993.
2. Gerschenson L.E., Rotello R.J.: Apoptosis: a different type of cell death. FASEB J., 6: 2450-2455, 1992.
3. Bowen I.D.: Apoptosis or programed cell death. Cell Biol. Int. 17: 365-380, 1993.
4. Lee S., Christakos S., Small M.B.: Apoptosis and signal transduction: clues to a molecular mechanism. Curr. Biol. 5: 2860-2911, 1993.
5. Walker P.R., Pandey S., Sikorska M.: Degradation of chomatin in apoptotic cells. Cell Death Diff. 2: 113-122, 1995.
6. Martin S.J., Green D.R., Cotter T.G.: Dicing with death: dissecting the components of the apoptosis machinery.Trends Biochem. Sci. 19: 33-37, 1994.
7. Cohen G.M., Sun X-M., Snowden R.T., Dinsdale D., Skilleter D.N.: Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation. J. Biochem. 386: 331-334, 1992.
8. Earnshaw W.C.: Nuclear changes in apoptosis. Curr. Opin. Cell Biol. 7:337-343, 1995.
9. Haecker G., Vaux X.: Viral, worm and radical implications for apoptosis. Trends Biochem. Sci. 19: 99-100, 1994.
10. Wyllie A.H.: Apoptosis (The 1992 Frank Rose Memorial Lecture). Br. J. Cancer. 67: 205-208, 1992.
11. Martin S.J.: Apoptosis: suicide execution or murder. Trends Cell Biol. 1: 141-144, 1993.
12. Martin S.J., Lennon S.V., Bonham A.M., Cotter T.G.: Induction of apoptosis (programmed cell death) in human leukemic HL-60 cells by inhibition of RNA or protein synthesis. J. Immunol. 145 :1859-1867, 1990.
13. Waring P.: DNA fragmentation induced in macrophages by gliotoxin does not require protein syntesis and is preceded by raised inositol triphosphate levels. J. Biol. Chem. 265: 14476-14480, 1990.
14. Perotti M., Taddei F., Mirabelli F., Vairetti M., Bellomo G., McConkey J., Orrenius S.: Calcium-dependet DNA fragmentation in human synovial cells exposed to cold shock. FEBS lett. 29: 331-334, 1990.
15. Berridge M.J., Dupont G.: Spatial and temporal signalling by calcium. Curr. Op. Cell Biol. 6: 267-274, 1994.
16. Bellomo G. Perotti M., Taddei F., Mirabelli F., Finardi G., Nicotera P., Orrenius S.: Tumor Necrosis Factor a induces apoptosis in mammary adenocarcinoma cells by an increase in intranuclear free Ca2+ concentration and DNA fragmentation. Cancer Res. 52: 1342-1346, 1992.
17. Zhivotovsky B., Cedervall B., Jiang S., Nicotera P., Orrenius S.: Involvement of Ca2+ in the formation of high molecular weight DNA fragments in thymocyte apoptosis. Biochem. Biophys. Res. Comm. 1: 120-127, 1994.
18. Matsubara K., Kubota M., Adachi S., Kuwakado K., Hirota H., Wakazono Y., Akiyama Y., Mikawa H.: Different mode of cell death induced by calcium ionophore in human leukemia cell lines: possible role of constitutive endonuclease. Exp. Cell Res. 210: 19-25, 1994.
19. Kluck R.M., McDougall C.A., Harmos B.V., Halliday J.W.: Calcium chelators induce apoptosis-evidence that raised intracellular ionised calcium is not essential for apoptosis. Biochim. Biophys. Acta 1223: 247-254, 1994.
20. Guano F., Bernardi R., Negri Cl., Donzelli M., Prosperi E., Ricotti G. A.I., Scovassi I.: Dose-depend zinc inhibition on DNA ladder in apoptotic HeLa cells regualtes the activity of (poly ADP-ribose) polymerase and does not protect from death induce by VP-16. Cell Death Diff. 1: 101-107, 1994.
21. Lowe S.W., Ruley H.E., Jacks T., Housman D.E.: p53-Dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74: 957-967, 1993.
22. Masuda H, Tanaka T., Takahama U.: Cisplatin generates superoxide anion by interaction with DNA in a cell-free system. Biochem. Biophys. Res. Comm. 203:1175-1180, 1994.
23. Ormerod M.G., O'Neill C.F., Robertson D., Harrap K.R.: Cisplatin induces apoptosis in a human ovarian carcinoma cell line without concomitant internucleosomal degradation of DNA. Exp. Cell. Res. 211: 231-237, 1994.
24. Sorenson C.S., Eastman A.: Mechanism of cis-d-amminedichloroplatinum(II)-induced cytotoxicity: role of G2 arrest and DNA double-strand breaks. Cancer Res. 48: 4484-4488, 1988.
25. Sorenson C.M., Barry M.A., Eastman A.: Analysis of events associated with cell cycle arrest at G2 phase and cell death induced by cisplatin. J. Natl. Cancer Inst. 82: 749-755, 1990.
26. Zhang J-G., Lindup E.W.: Cisplatin-Nephrotoxicity: decreases in mitochondria protein sulphydryl concentration and calcium uptake by mitochondria from rat renal cortical slices. Biochem. Pharmacol. 47: 1127-1135. 1995.
27. Fichtinger-Schepman A.M.J., van der Veer J.L., den Hartog J.H.J., Lohman P.H.M., Reedijk J.: Adducts of the antitumor drug cis-diamminedichloroplatinum (II) with DNA: formation, identification, and quantitation. Biochemistry 24: 707-713, 1995.
28. Maldonado V., Melendez J., Gonzalez H., Ortega A.: Internucleosomal DNA cleavage in HeLa cells exposed to cisplatin. Biochem. Mol. Biol. Int. 37: 691-696, 1995.
29. Meléndez-Zajgla J., García C., Maldonado, V.: Subcellular redistribution of Hsp72 protein during cisplatin-induced apoptosis in HeLa cells. Biochem. Mol. Biol. Int. 40: 253-261, 1996.