Alcohol acutely down-regulates urea synthesis in normal men

Alcoholism: Clinical and Experimental Research

Volumn 28, Issue 5, 2004, Pages 697-701

  Aagaard, Niels Kristian ^a   Thøgersen, Thøger ^a   Grøfte, Thorbjørn ^a   Greisen, Jacob ^a   Vilstrup, Hendrik ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Alcohol; Glucagon; Hepatic Urea Synthesis; Methylene Blue

Indexed keywords

ALANINE; ALCOHOL; GLUCAGON; GLUCOSE; METHYLENE BLUE; UREA;

ADULT; ALCOHOLISM; ARTICLE; BLOOD LEVEL; CLEARANCE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOWN REGULATION; EXPOSURE; GLUCOSE BLOOD LEVEL; HORMONAL REGULATION; HUMAN; HUMAN EXPERIMENT; MALE; NITROGEN BALANCE; NITROGEN METABOLISM; NORMAL HUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; UREA CYCLE;

ADULT; BLOOD UREA NITROGEN; CROSS-OVER STUDIES; DOWN-REGULATION; ETHANOL; HUMANS; MALE; METABOLIC CLEARANCE RATE; OXIDATION-REDUCTION; UREA;

ANIMALIA;

EID: 2442719180     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ALC.0000125355.31808.DC     Document Type: Article

References (23)

1. Berry MN, Gregory RB, Grivell AR, Phillips JW, Schon A (1994) The capacity of reducing-equivalent shuttles limits glycolysis during ethanol oxidation. Eur J Biochem 225:557-564.
2. Bunout D, Petermann M, Ugarte G, Barrera G, Iturriaga H (1987) Nitrogen economy in alcoholic patients without liver disease. Metabolism 36:651-653.
3. Cheema-Dhadli S, Halperin FA, Sonnenberg K, MacMillan V, Halperin ML (1987) Regulation of ethanol metabolism in the rat. Biochem Cell Biol 65:458-466.
4. Cronholm T (1993) Ethanol metabolism in isolated hepatocytes. Effects of methylene blue, cyanamide and penicillamine on the redox state of the bound coenzyme and on the substrate exchange at alcohol dehydrogenase. Biochem. Pharmacol 45:553-558.
5. Daemen-Gubbels CR, Groeneveld PH, Groeneveld AB, van Kamp GJ, Bronsveld W, Thijs LG (1995) Methylene blue increases myocardial function in septic shock. Crit Care Med 23:1363-1370.
6. De Feo P, Volpi E, Lucidi P, Cruciani G, Monacchia F, Reboldi G, Santeusanio F, Bolli GB, Brunetti P (1995) Ethanol impairs post-prandial hepatic protein metabolism. J Clin Invest 95:1472-1479.
7. Ellenhorn MJ, Barceloux DG (1988) Medical Toxicology. Part Four. Chemical Products. Elesvier Science, New York.
8. Fawcett JK, Scott JE (1960) A rapid and precise method for the determination of urea. J Clin Pathol 13:156.
9. Goodwin JF (1970) Spectrofotometric quantitation of plasma and urinary amino nitrogen with flourid. St Meth Clin Chem 6:89-98.
10. Grofte T, Wolthers T, Jorgensen JO, Poulsen PL, Vilstrup H, Moller N (1999) Hepatic amino- to urea-N clearance and forearm amino-N exchange during hypoglycemic and euglycemic hyperinsulinemia in normal man. J Hepatol 30:819-825.
11. Grunnet N, Thieden HI (1972) The effect of ethanol concentration upon in vivo metabolite levels of rat liver. Life Sci II 11:983-993.
12. Hamberg O (1997) Regulation of urea synthesis by diet protein and carbohydrate in normal man and in patients with cirrhosis. Relationship to glucagon and insulin. Dan Med Bull 44:225-241.
13. Jensen SA, Almdal TP, Vilstrup H (1991) Acute in vivo effects of low ethanol concentration on the capacity of urea synthesis in rats. Alcohol Clin Exp Res 15:90-93.
14. Krebs HA, Hems R, Lund P (1973) Accumulation of amino acids by the perfused rat liver in the presence of ethanol. Biochem J 134:697-705.
15. Orskov H, Thomsen HG, Yde H (1968) Wick chromatography for rapid and reliable immunoassay of insulin, glucagon and growth hormone. Nature (Lond.) 219:193-195.
16. Peter C, Hongwan D, Kupfer A, Lauterburg BH (2000) Pharmacokinetics and organ distribution of intravenous and oral methylene blue. Eur J Clin Pharmacol 56:247-250.
17. Pietro AS, Rittenberg D (1953) A study of the rate of protein synthesis in humans. J Biol Chem 201:445-455.
18. Preedy VR, Adachi J, Ueno Y, Ahmed S, Mantle D, Mullatti N, Rajendram R, Peters TJ (2001) Alcoholic skeletal muscle myopathy: definitions, features, contribution of neuropathy, impact and diagnosis. Eur J Neurol 8:677-687.
19. Rosa J, Rubin E (1980) Effects of ethanol on amino acid uptake by rat liver cells. Lab Invest 43:366-372.
20. Ryle PR, Chakraborty J, Thomson AD (1985) The effect of methylene blue on the hepatocellular redox state and liver lipid content during chronic ethanol feeding in the rat. Biochem J 232:877-882.
21. Vilstrup H (1980) Synthesis of urea after stimulation with amino acids: relation to liver function. Gut 21:990-995.
22. Vilstrup H (1989) On urea synthesis-regulation in vivo. Dan Med Bull 36:415-429.
23. Vonlanthen R, Beer JH, Lauterburg BH (2000) Effect of methylene blue on the disposition of ethanol. Alcohol Alcohol 35:424-426.