Modulation of carcinogen metabolism and DNA interaction by calcium glucarate in mouse skin

Toxicological Sciences

Volumn 79, Issue 1, 2004, Pages 47-55

  Gupta, Krishna P ^a   Singh, Jaya ^a  

^a CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

Author keywords

Calcium glucarate; Carcinogen metabolism; DNA binding; Skin; Thymidine kinase

Indexed keywords

BENZO[A]PYRENE; CARCINOGEN; DIMETHYLBENZ[A]ANTHRACENE; DNA; POLYCYCLIC AROMATIC HYDROCARBON; SACCHARATE CALCIUM; THYMIDINE KINASE; TRITIUM; UNSPECIFIC MONOOXYGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CARCINOGEN DNA INTERACTION; CARCINOGENESIS; CARCINOGENICITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA BINDING; DNA SYNTHESIS; ENZYME ACTIVITY; EPIDERMIS; FEMALE; IN VITRO STUDY; IN VIVO STUDY; METABOLIC ACTIVATION; METABOLISM; MICROSOME; MODULATION; MOUSE; NONHUMAN; SKIN; THYMUS; TOXICOKINETICS;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ADMINISTRATION, TOPICAL; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BENZO(A)PYRENE; CARCINOGENS; CATTLE; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; GLUCARIC ACID; MICE; MICROSOMES; SKIN; THYMIDINE KINASE; THYMUS GLAND; TIME FACTORS; TRITIUM;

ANIMALIA;

EID: 2442705397     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfh098     Document Type: Article

References (27)

1. Abou-Issa, H., Dwivedi, C., Curley, R. W., Kirkpatrick, R., Coolemans-Beynen, A., Engineer, F. N., Humphries, K. A., El-Masry, W., and Webb, T. E. (1993). Basis for the antitumor and chemopreventive activities of glucarate and the glucarate-retinoid combination. Anticancer Res. 13, 395-399.
2. Del Tito, B. J., Jr., Mukhtar, H., and Bickers, D. R. (1983). Inhibition of epidermal metabolism and DNA binding of benzo[a]pyrene by ellagic acid. Biochem. Biophys. Res. Commun. 114, 388-394.
3. Bickers, D. R., Dutta, C. T., and Mukhtar, H. (1982). Epidermis: A site for drug metabolism in neonatal rat skin. Studies on cytochrome P-450 content and mixed function oxidase and epoxide hydrolase activity. Mol. Pharmacol. 21, 239-247.
4. Boberg, E. W., Liem, A., Miller, E. C., and Miller, J. A. (1987). Inhibition by pentachlorophenol of the initiating and promoting activities of 1 hydroxysafrole for the formation of enzyme altered foci and tumors in rat liver. Carcinogenesis 8, 537-539.
5. Brookes, P., and Osborne, M. R. (1982). Mutation in mammalian cells by sterioisomers of the antibenzo[a]pyrene diol epoxide in relation to the extent and nature of the DNA reaction products. Carcinogenesis 3, 1223-1226.
6. Cavalieri, E. L., and Rogan, E. G. (1998). Central role of radical cation in metabolic activation of polycyclic aromatic hydrocarbon. Xenobiotica 25, 677-688.
7. Diamond, L., Defendi, V., and Brookes, P. (1967). The interaction of 7,12 dimethyl benz(a)anthracene with cells sensitive and resistant to toxicity induced by this carcinogen. Cancer Res. 27, 890-897.
8. Di Giovanni, J., and Slaga, T. J. (1981). Modification of polycyclic aromatic hydrocarbon carcinogenesis. In Polycyclic Hydrocarbons and Cancer (H. V. Gelboin and Ts'o, POP, Eds.). Academic Press, New York. 3, 259-292.
9. Dwivedi, C., Downie, A., and Webb, T. E. (1987). Net glucuronidation in different rat strains: Importance of microsomal β glucuronidase. FASEB J. 4, 303-307.
10. Dwivedi, C., Heck, J. W., Downie, A., Laroya, S., and Webb, T. E. (1990). Effect of calcium glucarate on β glucuronidase activity and glucarate content of vegetables and fruits. Biochem. Med. Metab. Biol. 43, 83-93.
11. Eastman, A., Sweetenham, J., and Bresnick, E. (1978). Comparison of in vivo and in vitro binding of polycyclic hydrocarbons to DNA. Chem. Biol. Interact. 23, 345-353.
12. Gupta, K. P., and Mehrotra, N. K. (1997). Differential effects of butyric acid on mouse skin tumorigenesis. Biomed. Environ. Sci. 10, 436-441.
13. Hannigam, B. M., Barnett, Y. A., Armstrong, D. B., Mckelvey-Martin, V. J., and McKenna, P. G. (1993). Thymidine kinase: The enzymes and their clinical usefulness. Cancer Biother. 8, 189-197.
14. Hu, X., Benson, P. J., Srivastava, A., Xia, H., Bleicher, R. J., Zaren, H. A., Awasthi, S., and Gelboin, H. V. (1980). Benzopyrene metabolism, activation, and carcinogenesis: Role of mixed function oxidases and related enzymes. Physiol. Rev. 60, 1107-1166.
15. Kakefuda, T., and Yamamoto, H. A. (1978). Modification of DNA by the benzo[a]pyrene metabolite diol epoxide r-7, t-8-dihydroxy-t-9-7, 8,9,10-tetrahydrobenzo[a]pyrene. Proc. Natl. Acad. Sci. USA 75, 415-417.
16. Kates, J., and Beeson, J. (1970). Ribonucleic acid synthesis in vaccinia virus. I. The mechanism of synthesis and release of RNA in vaccinia cores. J. Mol. Biol. 50, 1-18.
17. Lesca, P. (1982). Influence of the rate of 7,12-dimethyl benz anthracene metabolic activation, in vitro, on its binding to epidermal DNA and skin carcinogenesis. Carcinogenesis 2, 199-204.
18. Lowry, O. W., Rosebrough, M. J., Farr, A. L., and Randall, R. J. (1951). Protein measurement by folin phenol reagent. J. Biol. Chem. 193, 265-275.
19. Nebert, D. W., and Gelboin, H. V. (1968). Substrate inducible microsomal aryl hydrocarbon hydroxylase in mammalian cell culture. Assay and properties of induced enzymes. J. Biol. Chem. 243, 6242-6249.
20. Newbold, R. F., and Brookes, P. (1976). Exceptional mutagenecity of a benzo[a]pyrene diol epoxide in cultured mammalian cells. Nature 261, 52-54.
21. Phillips, D. H., and Sims, P. (1979). Polycyclic aromatic hydrocarbon metabolites: Their reactions with nucleic acids. In Chemical Carcinogens and DNA (P. L. Grover, Ed.), Vol. 2, pp. 29-57. CRC Press, Boca Raton, FL.
22. Sakamoto, S., Hirai, H., Taga, H., Uchikoshi, T., Sunaga, T., Endo, Y., Kuwa, K., Kudo, H., Kawachi, Y., Kasahara, N., et al. (1997). Thymidine kinase and α-fetoprotein as biochemical markers of hepatocarcinogenesis induced by 3′ methyl-4-dimethylaminobenzene treatment in rats. Carcinogenesis 11, 145-150.
23. Saul, K. (1976). Thymidine kinase, DNA synthesis, and cancer. Mol. Cell. Biochem. 11, 161-181.
24. Singh, J., and Gupta, K. P. (2003). Calcium glucarate protects tumor formation in mouse skin. Biomed. Environ. Sci. 16, 9-16.
25. Stoner, G. D., Schut, H. A., Daniel, F. B., and Dixit, R. A. (1986). Comparison of covalent DNA binding of benzo[a]pyrene and 7,12-dimethylbenzanthracene in respiratory tissues from human, rat and mouse. Cancer Lett. 30, 231-241.
26. Walaszek, Z., Hanausek-Walaszek, M., Minton, J. P., and Webb, T. E. (1987). Dietary Cag as antipromoter of 7,12-dimethyl benz anthracene induced mammary tumorigenesis. Carcinogenesis 7, 1463-1466.
27. Walaszek, Z., Szemraz, J., Hanausek, M., Adams, A. K., and Sherman, V. D. (1996). D-glucaric acid content of different fruits and vegetables and cholesterol lowering effects of dietary D-glucarate in the rats. Nutr. Res. 16, 673-681.