Benzylamine exhibits insulin-like effects on glucose disposal, glucose transport, and fat cell lipolysis in rabbits and diabetic mice

Journal of Pharmacology and Experimental Therapeutics

Volumn 309, Issue 3, 2004, Pages 1020-1028

  Iglesias Osma, María Carmen ^b   Garcia Barrado, Maria José ^b   Visentin, Virgile ^a   Pastor Mansilla, Maria Francisca ^b   Bour, Sandy ^a   Prévot, Daníelle ^a   Valet, Philippe ^a   Moratinos, Julio ^b   Carpéné, Christian ^a,c  

^a TOULOUSE UNIVERSITY HOSPITAL   (France)

^b UNIVERSITY OF SALAMANCA   (Spain)

^c CHU RANGUEIL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE OXIDASE (COPPER CONTAINING); AMINE OXIDASE (FLAVIN CONTAINING); BENZYLAMINE; GLUCOSE; HYDROGEN PEROXIDE; INSULIN; ISOPRENALINE; PERVANADATE; SEMICARBAZIDE; VANADIC ACID;

ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVATION; FEMALE; GLUCOSE METABOLISM; GLUCOSE TOLERANCE TEST; GLUCOSE TRANSPORT; HYPERGLYCEMIA; INSULIN LIKE ACTIVITY; INSULIN RELEASE; LIPID METABOLISM; LIPOLYSIS; MALE; MOUSE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RABBIT;

ADIPOCYTES; ANIMALS; BENZYLAMINES; BIOLOGICAL TRANSPORT; CARCINOGENS; DIABETES MELLITUS, EXPERIMENTAL; DRUG INTERACTIONS; GLUCOSE; GLUCOSE TOLERANCE TEST; INFUSIONS, INTRAVENOUS; INSULIN; ISLETS OF LANGERHANS; LIPOLYSIS; MICE; OXIDATION-REDUCTION; RABBITS; SEMICARBAZIDES; STARVATION;

EID: 2442674057     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.063636     Document Type: Article

References (36)

1. Abella A, Marti L, Camps M, Claret M, Fernandez-Alvarez J, Gomis R, Gumà A, Viguerie N, Carpéné C, Palacin M, et al. (2003) Semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 activity exerts an antidiabetic action in Goto-Kakizaki rats. Diabetes 52:1004-1013.
2. Blaschko H (1952) Amine oxidase and amine metabolism. Pharmacol Rev 4:415-458.
3. Buffoni F (1995) Semicarbazide-sensitive amine oxidases: some biochemical properties and general considerations. Progr Brain Res 106:323-331.
4. Burcelin R, Crivelli V, Dacosta A, Roy-Tirelli A, and Thorens B (2002) Heterogeneous metabolic adaptation of C57BL/6J mice to high-fat diet. Am J Physiol 282:E834-E842.
5. Castan I, Wijkander J, Manganiello V, and Degerman E (1999) Mechanisms of inhibition of lipolysis by insulin, vanadate and peroxovanadate in rat adipocytes. Biochem J 339:281-289.
6. Enrique-Tarancon G, Castan I, Morin N, Marti L, Abella A, Camps M, Casamitjana R, Palacin M, Testar X, Degerman E, et al. (2000) Substrates of semicarbazide-sensitive amine oxidase cooperate with vanadate to stimulate tyrosine phosphorylation of IRS proteins, phosphatidylinositol 3-kinase activity and GLUT4 translocation in adipose cells. Biochem J 350:171-180.
7. Enrique-Tarancon G, Marti L, Morin N, Lizcano JM, Unzeta M, Sevilla L, Camps M, Palacin M, Testar X, Carpéné C, et al. (1998) Role of semicarbazide-sensitive amine oxidase on glucose transport and GLUT4 recruitment to the cell surface in adipose cells. J Biol Chem 273:8025-8032.
8. Fontana E, Boucher J, Marti L, Lizcano JM, Testar X, Zorzano A, and Carpéné C (2001) Amine oxidase substrates mimic several of the insulin effects on adipocyte differentiation in 3T3 F442A cells. Biochem J 356:769-777.
9. Fowler CJ and Tipton KF (1981) Concentration dependence of the oxidation of tyramine by the two forms of rat liver mitochondrial monoamine oxidase. Biochem Pharmacol 30:3329-3332.
10. García-Barrado MJ, Sancho C, Iglesias-Osma MC, and Moratinos J (2001) Effects of verapamil and elgodipine on isoprenaline-induced metabolic responses in rabbits. Eur J Pharmacol 415:105-115.
11. Huyer G, Liu S, Kelly J, Moffa J, Payette P, Kennedy B, Tsaprailis G, Gresser MJ, and Ramachadran C (1997) Mechanism of inhibition of protein-tyrosine phosphatases by vanadate and pervanadate. J Biol Chem 272:843-851.
12. + channels in pancreatic β-cells. Eur J Pharmacol 264:81-84.
13. Langford SD, Trent MB, and Boor PJ (2002) Semicarbazide-sensitive amine oxidase and extracellular matrix deposition by smooth-muscle cells. Cardiovasc Toxicol 2:141-150.
14. Little SA and De Haën C (1980) Effects of hydrogen peroxide on basal and hormone-stimulated lipolysis in perifused rat fat cells in relation to the mechanism of action of insulin. J Biol Chem 255:10888-10895.
15. Lyles GA (1996) Mammalian plasma and tissue-bound semicarbazide-sensitive amine oxidases: biochemical, pharmacological and toxicological aspects. Int J Biochem Cell Biol 28:259-274.
16. Marti L, Abella A, Carpéné C, Palacin M, Testar X, and Zorzano A (2001) Combined treatment with benzylamine and low dosages of vanadate enhances glucose tolerance and reduces hyperglycemia in streptozotocin-induced diabetic rats. Diabetes 50:2061-6068.
17. Marti L, Morin N, Enrique-Tarancon G, Prévot D, Lafontan M, Testar X, Zorzano A, and Carpéné C (1998) Tyramine and vanadate synergistically stimulate glucose transport in rat adipocytes by amine oxidase-dependent generation of hydrogen peroxide. J Pharmacol Exp Ther 285:342-349.
18. May JM and De Haën C (1979) The insulin-like effect of hydrogen peroxide on pathways of lipid synthesis in rat adipocytes. J Biol Chem 254:9017-9021.
19. Mercier N, Moldes M, El Hadri K, and Fève B (2001) Semicarbazide-sensitive amine oxidase activation promotes adipose conversion of 3T3-L1 cells. Biochem J 358:335-342.
20. Mercier N, Moldes M, El Hadri K, and Fève B (2003) Regulation of semicarbazide-sensitive amine oxidase expression by tumor necrosis factor-a in adipocytes: functional consequences on glucose transport. J Pharmacol Exp Ther 304:1197-1208.
21. Moratinos J, Carpéné C, De Pablos I, and Reverte M (1988) Role of α1- and α2-adrenoceptors in catecholamine induced hyperglycaemia, lipolysis and insulin secretion in conscious fasted rabbits. Br J Pharmacol 24:299-310.
22. Moratinos J, Olmedilla B, De Pablos I, and Vigueras MD (1986) Alpha adrenoceptor involvement in catecholamine-induced hyperglycaemia in conscious fasted rabbits. Br J Pharmacol 89:55-66.
23. Morin N, Lizcano JM, Fontana E, Marti L, Smih F, Rouet P, Prevot D, Zorzano A, Unzeta M, and Carpéné C (2001) Semicarbazide-sensitive amine oxidase substrates stimulate glucose transport and inhibit lipolysis in human adipocytes. J Pharmacol Exp Ther 297:563-572.
24. Morin N, Visentin V, Calise D, Marti L, Zorzano A, Testar X, Valet P, Fischer Y, and Carpéné C (2002) Tyramine stimulates glucose uptake in insulin-sensitive tissues in vitro and in vivo via its oxidation by amine oxidases. J Pharmacol Exp Ther 303:1238-1247.
25. Morris NJ, Ducret A, Aebersold R, Ross SA, Keller SR, and Lienhard GE (1997) Membrane amine oxidase cloning and identification as a major protein in the adipocyte plasma membrane. J Biol Chem 272:9388-9392.
26. Nolte LA, Han DH, Hansen PA, Hucker KA, and Holloszy JO (2003) A peroxovanadium compound stimulates muscle glucose transport as powerfully as insulin and contractions combined. Diabetes 52:1918-1925.
27. Raimondi L, Pirisino R, Ignesti G, Capecchi S, Banchelli G, and Buffoni F (1991) Semicarbazide-sensitive amine oxidase activity (SSAO) of rat epididymal white adipose tissue. Biochem Pharmacol 41:467-470.
28. Randle PJ (1998) Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years. Diabetes Metab Rev 14:263-283.
29. Randle PJ, Garland PB, Hales CN, and Newsholme EA (1963) The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1:785-789.
30. Randle PJ, Kerbey AL, and Espinal J (1988) Mechanisms decreasing glucose oxidation in diabetes and starvation: role of lipid fuels and hormones. Diabetes Metab Rev 4:623-638.
31. Salmi M, Yegutkin GG, Lehvonen R, Koskinen K, Salminen T, and Jalkanen S (2001) A cell surface amine oxidase directly controls lymphocyte migration. Immunity 14:1-20.
32. Salminen TA, Smith DJ, Jalkanen S, and Johnson MS (1998) Structural model of the catalytic domain of an enzyme with cell adhesion activity: human vascular adhesion protein-1 (hVAP-1) D4 domain is an amine oxidase. Protein Eng 11:1195-1204.
33. Valet P, Tavernier G, Castan-Laurell I, Saulnier-Blache JS, and Langin D (2002) Understanding adipose tissue development from transgenic animal models. J Lipid Res 43:835-860.
34. Visentin V, Prevot D, Marti L, and Carpéné C (2003) Inhibition of rat fat cell lipolysis by monoamine oxidase and semicarbazide-sensitive amine oxidase substrates. Eur J Pharmacol 466:235-243.
35. Yu PH, Wang M, Fan H, Deng Y, and Gubisne-Haberle D (2004) Involvement SSAO-mediated deamination in adipose glucose transport and weight gain in obese diabetic KKAy mice. Am J Physiol 286:E634-E641.
36. Yu PH, Wright S, Fan EH, Lun ZR, and Gubisne-Haberle D (2003) Physiological and pathological implications of semicarbazide-sensitive amine oxidase. Biochim Biophys Acta 1647:193-199.