Is Berlina grandiflora (Leguminosae) toxic in rats?

Phytomedicine

Volumn 11, Issue 4, 2004, Pages 352-360

  Aniagu, Stanley O ^a,d   Nwinyi, F C ^a   Olanubi, B ^a   Akumka, D D ^a   Ajoku, G A ^a   Izebe, K S ^a   Agala, P ^a   Agbani, E O ^b   Enwerem, N M ^a   Iheagwara, C ^c   Gamaniel, K S ^a  

^a NATIONAL INSTITUTE FOR PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (Nigeria)

^b OBAFEMI AWOLOWO UNIVERSITY   (Nigeria)

^c Idu industrial Area ^*  (Nigeria)

^d UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Clinical chemistry; Hematology; Organ weight; Pathology; Toxicity

Indexed keywords

ALBUMIN; ALKALINE PHOSPHATASE; BERLINA GRANDIFLORA EXTRACT; CALCIUM; CREATINE KINASE; GAMMA GLUTAMYLTRANSFERASE; PLANT EXTRACT; PROTEIN; UNCLASSIFIED DRUG; UREA; URIC ACID;

ALBUMIN BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BERLINA GRANDIFLORA; BIOCHEMISTRY; BODY WEIGHT; CELL VOLUME; CLINICAL FEATURE; CONTROLLED STUDY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG ISOLATION; ENZYME ASSAY; FEMALE; HEART; HEMATOLOGY; HEMOGLOBIN DETERMINATION; HISTOPATHOLOGY; KIDNEY; LD 50; LEGUME; LEUKOCYTE COUNT; LIVER; LUNG; MALE; MEDICINAL PLANT; MORTALITY; MOUSE; NONHUMAN; ORGAN WEIGHT; PATHOLOGICAL ANATOMY; PLANT STEM; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; SPLEEN; STATISTICAL SIGNIFICANCE; TESTIS; TISSUE INJURY; TOXICITY; TOXICITY TESTING; UREA NITROGEN BLOOD LEVEL;

ANIMALIA; BERLINA GRANDIFLORA; FABACEAE;

EID: 2442670067     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1078/0944711041495155     Document Type: Article

References (27)

1. Al-Mamary M, Al-Habori M, Al-Aghbari AM, Baker MM (2002) Investigation into the toxicological effects of Catha edulis leaves: a short -term study in animals. Phytother Res 16: 127-32
2. Asuzu IU, Nwelle OC, Anaga AO (1993) The Pharmacological activities of the methanolic bark of Berlina grandiflora. Fitoterapia 64: 529-534
3. Asuzu IU, Onu OU (1994) Antihelmithic activity of the ethanolic of Piliostigma thoningii bark in Ascarida galli infected chickens. Fitoterapia 65: 291-294
4. th Edition. Butterworths, London
5. Boelsterli UA (2003) Mechanistic Toxicology. Taylor and francis. London
6. Chamorro G, Salazar M (1996) Dominant lethal study of Spirulina maxima in male and female rats after short-term feeding. Phytother Res 10: 28-32
7. Dalziel JM (1937) The Useful Plants of West Tropical Africa. The Crown Agents for the Colonies, London
8. Dunnett C, Goldsmith C (1993) In: Buncher, CR and Tsay, JY (Eds.), Statistics in the Pharmaceutical Industry 2nd ed, Marcel Dekker, New York
9. Enwerem NM (1999) A phytochemical and anthelmintic activity investigation of the stem bark extracts of Berlina grandiflora Dutch and Dalz. Ph.D Thesis. Department of Chemistry, Faculty of Science, University of Ibadan, Nigeria
10. Enwerem NM, Okogun JI, Wambebe CO, Okorie DA, Akah PA (2001a) Antihelmithic activity of the stem bark extracts of Berlina grandiflora and one of its active principles, Betulinic acid. Phytomedicine 8: 112-114
11. Enwerem NM, Wambebe CO, Okogun JI, Akah PA, Gamaniel KS (2001b) Antihelmithic screening of the stem bark of Berlina grandiflora. Journal of Natural Remedies 1/1: 17-20
12. th Ed (International Edition), Mc Graw Hill, New York
13. Jain NC (1986) Schalm's Veterinary Pharmacology. LEA and Febiger, Philadelphia
14. Kaneko JJ (1989) Clinical Biochemistry of Domestic animals. Academic Press, San Diego
15. th Edition McGraw-Hill, New York
16. Lorke D (1983) A new approach to practical acute toxicity testing. Arch Toxicology 54: 275-287
17. rd edn. McGraw Hill, New York
18. th Edition (International Students Edition), Arnold London/Oxford University Press Inc. New York
19. McNamara BP (1976) Concepts in health evaluation of commercial and industrial chemicals In: Mehlman MA, Shapiro RE, Blumental H (eds). New concepts in safety evaluation. Hemisphere, Washington D.C.
20. NIH Publication # 85-23 (1985) Respect for Life National Institute of Environmental Health Sciences - NIEHS: http://www.niehs.nih.gov/oc/factsheets/wrl/studybgn.htm
21. Petersen RG (1985) Design and Analysis of Experiments. Marcel Dekker, New York
22. Scheffe H (1964) The Analysis of Variance. Wiley, New York
23. st edition. Spectrum Books Ltd., Ibadan - Nigeria
24. Tiez NW (1986) Fundamentals of Clinical Chemistry, W.B. Saunders Co., Philadelphia, p 723
25. rd Edition Taylor and Francis, London
26. World Health Organisation (1998) Basic OECD Principles of GLP (www.who.int/tdr/publications)
27. Zhu M, Lew KT, Leung P (2002) Protective Effects of Plant formula on Ethanol-induced gastric Lesions in Rats. Phytother Res 16: 276-280