Severe encephalopathy with epilepsy in an infant caused by subclinical maternal pernicious anaemia: Case report and review of the literature

European Journal of Pediatrics

Volumn 163, Issue 4-5, 2004, Pages 196-201

  Korenke, G Christoph ^a,c   Hunneman, Donald H ^a   Eber, Stefan ^b   Hanefeld, Folker ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^c KLINIKUM OLDENBURG   (Germany)

Author keywords

Epilepsy; Megaloblastic anaemia; Methylmalonic acid; Pernicious anaemia; Vitamin B12 deficiency

Indexed keywords

CYANOCOBALAMIN; HYDROXOCOBALAMIN; METHYLMALONIC ACID; PHENOBARBITAL; PYRIDOXINE;

BRAIN DISEASE; CASE REPORT; CLINICAL FEATURE; CORPUS CALLOSUM; CYANOCOBALAMIN DEFICIENCY; EPILEPSY; FEMALE; FOLLOW UP; HEAD CIRCUMFERENCE; HUMAN; HUMAN TISSUE; HYPOPLASIA; INFANT; MEGALOBLASTIC ANEMIA; MENTAL DEFICIENCY; METHYLMALONIC ACIDURIA; NUCLEAR MAGNETIC RESONANCE IMAGING; PERNICIOUS ANEMIA; PRIORITY JOURNAL; REVIEW; SEIZURE; URINE LEVEL;

ANEMIA, PERNICIOUS; BRAIN; BRAIN DISEASES, METABOLIC; ELECTROENCEPHALOGRAPHY; EPILEPSY; FEMALE; HUMANS; INFANT; MAGNETIC RESONANCE IMAGING; PREGNANCY; PREGNANCY COMPLICATIONS, HEMATOLOGIC; VITAMIN B 12 DEFICIENCY;

EID: 2442668914     PISSN: 03406199     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00431-004-1402-4     Document Type: Review

References (27)

1. Allen LH (1994) Vitamin B12 metabolism and status during pregnancy, lactation and infancy. Adv Exp Med Biol 352: 173-186
2. Frenkel E (1973) Abnormal fatty acid metabolism in peripheral nerve of patients with pernicious anaemia. J Clin Invest 52: 1237-1245
3. Frery N, Huel G, Leroy M, Moreau T, Savard R, Blot P, Lellouch J (1992) Vitamin B12 among parturients and their newborns and its relationship with birthweight. Eur J Obstet Gynecol Reprod Biol 45: 155-163
4. Giugliani ER, Jorge SM, Goncalves AL (1985) Serum vitamin B12 levels in parturients, in the intervillous space of the placenta and in full-term newborns and their interrelationships with folate levels. Am J Clin Nutr 41: 330-335
5. Graham SM, Arvela OM, Wise GA (1992) Long-term neurologic consequences of nutritional vitamin B12 deficiency in infants. J Pediatr 121: 710-714
6. Hoey H, Linnell JC, Oberholzer VG, Laurence BM (1982) Vitamin B12 deficiency in a breast fed infant of a mother with pernicious anaemia. J Roy Soc Med 75: 656-658
7. Jadhav M, Webb J, Vaishnava S, Baker S (1962) Vitamin B12 deficiency in Indian infants. Lancet 2: 903-907
8. Johnson PR, Roloff JS (1982) Vitamin B12 deficiency in an infant strictly breast-fed by a mother with latent pernicious anaemia. J Pediatr 100: 917-919
9. Kuehne T, Bubl R, Baumgartner R (1991) Maternal vegan diet causing a serious infantile neurological disorder due to vitamin B12 deficiency. Eur J Pediatr 150: 205-208
10. Lampkin BC, Shore NA, Chadwick D (1966) Megaloblastic anemia of infancy secondary to maternal pernicious anemia. N Engl J Med 274: 1168-1171
11. Lövblad K, Ramelli G, Remonda L, Nirkko AC, Ozdoba C, Schroth G (1997) Retardation of myelination due to dietary vitamin B12 deficiency: cranial MRI findings. Pediatr Radiol 27: 155-158
12. Lundgren J, Blennow G (1999) Vitamin B12 deficiency may cause benign familial infantile convulsions: a case report. Acta Paediatr 88: 1158-1160
13. Mattson MP, Shea TB (2003) Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci 26: 137-146
14. 12 deficiency in a breast fed infant. Arch Dis Child 63: 921-923
15. Michaud JL, Lemieux B, Ogier H, Lambert MA (1992) Nutritional vitamin B12 deficiency: two cases detected by routine newborn urinary screening. Eur J Pediatr 151: 218-220
16. Monagle PT, Tauro GP (1997) Infantile megaloblastosis secondary to maternal vitamin B12 deficiency. Clin Lab Haematol 19: 23-25
17. Mudd SH, Poole JR (1975) Labile methyl balances for normal humans on various dietary regimens. Metabolism 24: 721-735
18. Ogier de Baulny H, Gerard M, Saudubray JM, Zittoun J (1998) Remethylation defects: guidelines for clinical diagnosis and treatment. Eur J Pediatr 157[Suppl 2]: S77-S83
19. Oh R, Brown DL (2003) Vitamin B12 deficiency. Am Fam Physician 67:979-986
20. Pearson AGM, Turner AJ (1975) Folate dependent 1-carbon transfer to biogenic amines mediated by methylenetetrahydrofolate reductase. Nature 258: 173-174
21. Rosenblatt DS, Whitehead VM (1999) Cobalamin and folate deficiency: acquired and hereditary disorders in children. Semin Hematol 36: 19-34
22. von Schenck U, Bender-Götze C, Koletzko B (1997) Persistence of neurological damage induced by dietary vitamin B-12 deficiency in infancy. Arch Dis Child 77: 137-139
23. Schulze A (2003) Creatine deficiency syndromes. Mol Cell Biochem 244: 143-150
24. Specker BL, Miller D, Norman EJ, Greene H, Hayes KC (1988) Increased urinary methylmalonic acid excretion in breast-fed infants of vegetarian mothers and identification of an acceptable dietary source of vitamin B-12. Am J Clin Nutr 47: 89-92
25. Specker BL, Black A, Allen L, Morrow F (1990) Vitamin B-12: low milk concentrations are related to low serum concentrations in vegetarian women and to methylmalonic aciduria in their infants. Am J Clin Nutr 52: 1073-1076
26. Stollhoff K, Schulte FJ (1987) Vitamin B12 and brain development. Eur J Pediatr 146: 201-205
27. Willoughby MLN (1977) Vitamin B12 metabolism and deficiency. In: Willoughby MLN (ed) Paediatric haematology. Churchill Livingstone, Edinburgh, pp 35-42