Inhibition of the Class II HMG-CoA reductase of Pseudomonas mevalonii

Protein Science

Volumn 13, Issue 6, 2004, Pages 1693-1697

  Hedl, Matija ^a   Rodwell, Victor W ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

Class II HMG CoA reductase; HMG CoA reductase; Isoprenoid biosynthesis; Lovastatin; Pseudomonas mevalonii; Statin drug

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; ISOPENTENYL DIPHOSPHATE; MEVALONIC ACID; MEVINOLIN; STATINE DERIVATIVE;

ARTICLE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME STRUCTURE; EUBACTERIUM; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS; PSEUDOMONAS MEVALONII; STRUCTURE ANALYSIS;

ESCHERICHIA COLI; GENE EXPRESSION; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; KINETICS; LOVASTATIN; MEVALONIC ACID; MOLECULAR STRUCTURE; PSEUDOMONAS;

BACTERIA (MICROORGANISMS); EUKARYOTA; NEGIBACTERIA; PSEUDOMONAS; PSEUDOMONAS MEVALONII;

EID: 2442661382     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.03597504     Document Type: Article

References (20)

1. Alberts, A.W., Chen, J., Kuron, G., Hunt, V., Huff, J., Hoffman, C., Rothrock, J., Lopez, M., Joshua, H., Harris, E., et al. 1980. Mevinolin: A highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proc. Nat. Acad. Sci. 77: 3957-3961.
2. Baker, F.C. and Schooley, D.A. 1981. Biosynthesis of 3-hydroxy-3-methylglutaryl-CoA, 3-hydroxy-3-ethylglutaryl-CoA, mevalonate and homomevalonate by insect corpus allatum and mammalian hepatic tissues. Biochim. Biophys. Acta 664: 356-372.
3. Beach, M.J. and Rodwell, V.W. 1989. Cloning, sequencing, and overexpression of mvaA, which encodes Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl coenzyme A reductase. J. Bacteriol. 171: 2994-3001.
4. Bischoff, K.M. and Rodwell, V.W. 1996. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase from Haloferax volcanii: Purification, characterization, and expression in Escherichia coli. J. Bacteriol. 178: 19-23.
5. Bochar, D.A., Brown, J.R., Doolittle, W.F., Klenk, H.P., Lam, W., Schenk, M.E., Stauffacher, C.V., and Rodwell, V.W. 1997. 3-Hydroxy-3-methylglutaryl coenzyme A reductase of Sulfolobus solfataricus: DNA sequence, phylogeny, expression in Escherichia coli of the hmgA gene, and purification and kinetic characterization of the gene product. J. Bacteriol. 179: 3632-3638.
6. Bochar, D.A., Stauffacher, C.V., and Rodwell, V.W. 1999. Sequence comparisons reveal two classes of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Mol. Genet. Metab. 66: 122-127.
7. Dairi, T., Motohira, Y., Kuzuyama, T., Takahashi, S., Itoh, N., and Seto, H. 2000. Cloning of the gene encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase from terpenoid antibiotics-producing Streptomyces strains. Mol. Gen. Genet. 262: 957-964.
8. Endo, A. 1992. The discovery and development of HMG-CoA reductase inhibitors. J. Lipid. Res. 33: 1569-1582.
9. Fimognari, G.M., and Rodwell, V.W. 1965. Substrate-competitive inhibition of bacterial mevalonate:nicotinamide adenine dinucleotide oxidoreductase (acylating CoA). Biochemistry 4: 2086-2090.
10. Frimpong, K. and Rodwell, V.W. 1994. Catalysis by Syrian hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Proposed roles of histidine 865, glutamate 558, and aspartate 766. J. Biol. Chem. 269: 11478-11483.
11. Hedl, M., Sutherlin, A.L., Wilding, E.I., Mazzulla, M., McDevitt, D., Lane, P., Burgner 2nd, J.W., Lehnbeuter, K.R., Stauffacher, C.V., Gwynn, M.N., et al. 2002. Enterococcus faecalis acetoacetyl-coenzyme A thiolase/3-hydroxy-3-methylglutaryl-coenzyme A reductase, a dual-function protein of isopentenyl diphosphate biosynthesis. J. Bacteriol. 184: 2116-2122.
12. Istvan, E.S. and Deisenhofer, J. 2001. Structural mechanism for statin inhibition of HMG-CoA reductase. Science 292: 1160-1164.
13. Jordan-Starck, T.C. and Rodwell, V.W. 1989. Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl-CoA reductase characterization and chemical modification. J. Biol. Chem. 264: 17913-17918.
14. Karl, R.M., Hupperich, M., Thomer, A., and Eggerer, H. 1995. Inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase and citrate synthase by sulfoxides and sulfones of substrate-analogue CoA-thioether derivatives. Eur. J. Biochem. 227: 292-295.
15. Kim, D.-Y., Stauffacher, C.V., and Rodwell, V.W. 2000. Dual coenzyme specificity of Archaeoglobus fulgidus HMG-CoA reductase. Protein Sci. 9: 1226-1234.
16. Rodwell, V.W., Beach, M.J., Bischoff, K.M., Bochar, D.A., Darnay, B.G., Friesen, J.A., Gill, J.F., Hedl, M., Jordan-Starck, T.C., Kennelly, P.J., et al. 2000. 3-Hydroxy-3-methylglutaryl-CoA reductase. Methods Enzymol. 324: 259-280.
17. Tabernero, L., Rodwell, V.W., and Stauffacher, C.V. 2003. Crystal structure of a statin bound to a class II HMG-CoA reductase. J. Biol. Chem. 278: 19933-19938.
18. Takahashi, S., Kuzuyama, T., and Seto, H. 1999. Purification, characterization, and cloning of a eubacterial 3-hydroxy-3-methylglutaryl coenzyme A reductase, a key enzyme involved in biosynthesis of terpenoids. J. Bacteriol. 181: 1256-1263.
19. Wilding, E.I., Brown, J.R., Bryant, A.P., Chalker, A.F., Holmes, D.J., Ingraham, K.A., Iordanescu, S., So, C.Y., Rosenberg, M., and Gwynn, M.N. 2000a. Identification, evolution, and essentiality of the mevalonate pathway for isopentenyl diphosphate biosynthesis in Gram-positive cocci. J. Bacteriol. 182: 4319-4327.
20. Wilding, E.I., Kim, D.-Y., Bryant, A.P., Gwynn, M.N., Lunsford, R.D., McDevitt, D., Myers Jr., J.E., Rosenberg, M., Sylvester, D., Stauffacher, C.V., et al. 2000b. Essentiality, expression and characterization of the Class II HMG-CoA reductase of Staphylococcus aureus. J. Bacteriol. 182: 5147-5152.